GRP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRP4_MOUSE
• UniProt AC: Q8BTM9
• Protein Name: RAS guanyl-releasing protein 4
• Gene Name: Rasgrp4
• Organism: Mus musculus (Mouse).
• Sequence Length: 673
• Subcellular Localization: Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
• Protein Description: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation..
• Protein Sequence: MNRKDIKRKSHQECSGKAGGRGRSRQARRHKTCPTPREISKVMASMNLGVLSESSCSEDELLEECIRCFDSAGSLRRGDHILKMVLTMHSWVLPSSELAARLLTSYQKAAKDAQELRQLQICYLVRYWLTHHHEAVHQEPQLEAVISRFWTTVAQEGNMAQRSLGDASSLLSPGGPGPPPPMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAHYRRTWAGCTGFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELMALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFKAPVVVEWAQGVTPKPDSVTLGQHVEQLVESVFKNYDPEGRGSISLEDFERLSGNFPFACHGLHPPPRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCSGFLWGVTKQGYRCRDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPVPATSLPPANCGSEESLSYTLSPDPESGCHLRHAWTQTESSHSSWEPEVVPCPARVLPSRASSKPSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	KAGGRGRSRQARRHK CCCCCCHHHHHHHCC	31.41	29472430
32	Phosphorylation	RQARRHKTCPTPREI HHHHHCCCCCCHHHH	20.00	25266776
35	Phosphorylation	RRHKTCPTPREISKV HHCCCCCCHHHHHHH	36.80	-
40	Phosphorylation	CPTPREISKVMASMN CCCHHHHHHHHHHCC	17.91	-
169	Phosphorylation	RSLGDASSLLSPGGP HHHCCHHHHCCCCCC	34.74	22871156
172	Phosphorylation	GDASSLLSPGGPGPP CCHHHHCCCCCCCCC	27.13	22871156
184	Phosphorylation	GPPPPMSSPGLGKKR CCCCCCCCCCCCCHH	19.41	22006019
228	Phosphorylation	TPQDLRGYVLQGSVR CHHHHCHHHHCCCCC	7.49	28576409
524	Phosphorylation	SREELTKYLLHASAI CHHHHHHHHHHHHHH	14.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRP4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRP4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRP4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.