dbPTM

PPAC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPAC_MOUSE
UniProt AC	Q9D358
Protein Name	Low molecular weight phosphotyrosine protein phosphatase
Gene Name	Acp1
Organism	Mus musculus (Mouse).
Sequence Length	158
Subcellular Localization	Cytoplasm.
Protein Description	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates..
Protein Sequence	MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEVGSKSV ------CCCCCCCEE	21.85	-
35	Acetylation	RKLVTDEKVSDNWRI HHHCCCCCCCCCEEE	50.26	23954790
35	Ubiquitination	RKLVTDEKVSDNWRI HHHCCCCCCCCCEEE	50.26	-
49	Phosphorylation	IDSAATSTYEVGNPP ECCCCCCEEECCCCC	21.24	24224561
62 (in isoform 2)	Phosphorylation	-	25.11	25367039
66	Acetylation	RGQNCMRKHGIHMQH CCCCHHHHCCCCHHH	21.21	22826441
88	Phosphorylation	EDFATFDYILCMDES HHHCCCCEEEEECHH	7.50	75123
113	Ubiquitination	QVKNCKAKIELLGSY HHCCHHHHHHCCCCC	23.39	-
132	Phosphorylation	QLIIEDPYYGNDSDF CEEEECCCCCCCCHH	36.01	22817900
133	Phosphorylation	LIIEDPYYGNDSDFE EEEECCCCCCCCHHH	18.16	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PPAC_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PPAC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPAC_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CTNB1_MOUSE	Ctnnb1	physical	12438242

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PPAC_MOUSE

Related Literatures of Post-Translational Modification