KAD1_MOUSE - dbPTM
KAD1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KAD1_MOUSE
UniProt AC Q9R0Y5
Protein Name Adenylate kinase isoenzyme 1 {ECO:0000255|HAMAP-Rule:MF_03171}
Gene Name Ak1
Organism Mus musculus (Mouse).
Sequence Length 194
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility..
Protein Sequence MEEKLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLSAIMEKGELVPLDTVLDMLRDAMLAKVDSSNGFLIDGYPREVKQGEEFEQKIGQPTLLLYVDAGAETMTQRLLKRGETSGRVDDNEETIKKRLETYYNATEPVISFYDKRGIVRKVNAEGTVDTVFSEVCTYLDSLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEEKLKKA
-------CHHHHHCC		15.75-
19PhosphorylationFVVGGPGSGKGTQCE
EEECCCCCCCHHHHH		40.2328464351
21UbiquitinationVGGPGSGKGTQCEKI
ECCCCCCCHHHHHHH		61.5622790023
21 (in isoform 2)Ubiquitination-61.5622790023
25S-nitrosocysteineGSGKGTQCEKIVQKY
CCCCHHHHHHHHHHH		6.05-
25S-nitrosylationGSGKGTQCEKIVQKY
CCCCHHHHHHHHHHH		6.0521278135
27UbiquitinationGKGTQCEKIVQKYGY
CCHHHHHHHHHHHCC		56.66-
27AcetylationGKGTQCEKIVQKYGY
CCHHHHHHHHHHHCC		56.6622826441
31AcetylationQCEKIVQKYGYTHLS
HHHHHHHHHCCCCCC		29.7421728379
31UbiquitinationQCEKIVQKYGYTHLS
HHHHHHHHHCCCCCC		29.7422790023
31 (in isoform 2)Ubiquitination-29.7422790023
32PhosphorylationCEKIVQKYGYTHLST
HHHHHHHHCCCCCCH		9.7729514104
34PhosphorylationKIVQKYGYTHLSTGD
HHHHHHCCCCCCHHH		6.4629514104
35PhosphorylationIVQKYGYTHLSTGDL
HHHHHCCCCCCHHHH		16.3929550500
37 (in isoform 2)Ubiquitination-3.65-
38PhosphorylationKYGYTHLSTGDLLRA
HHCCCCCCHHHHEEE		23.8026824392
39PhosphorylationYGYTHLSTGDLLRAE
HCCCCCCHHHHEEEE		40.8623737553
47 (in isoform 2)Ubiquitination-5.57-
48PhosphorylationDLLRAEVSSGSERGK
HHEEEECCCCCHHHH		22.0828542873
51PhosphorylationRAEVSSGSERGKKLS
EEECCCCCHHHHHHH		26.5228542873
56UbiquitinationSGSERGKKLSAIMEK
CCCHHHHHHHHHHHC		50.9622790023
56 (in isoform 2)Ubiquitination-50.9622790023
58PhosphorylationSERGKKLSAIMEKGE
CHHHHHHHHHHHCCC		25.3226824392
72 (in isoform 2)Ubiquitination-4.21-
83 (in isoform 2)Ubiquitination-42.4822790023
83UbiquitinationLRDAMLAKVDSSNGF
HHHHHHHCCCCCCCE		42.4822790023
86PhosphorylationAMLAKVDSSNGFLID
HHHHCCCCCCCEEEC		28.7925293948
87PhosphorylationMLAKVDSSNGFLIDG
HHHCCCCCCCEEECC		36.1925293948
99 (in isoform 2)Ubiquitination-6.23-
100 (in isoform 2)Ubiquitination-48.0822790023
100UbiquitinationDGYPREVKQGEEFEQ
CCCCCCCCCHHHHHH		48.0822790023
116UbiquitinationIGQPTLLLYVDAGAE
HCCCEEEEEEECCCH		4.3927667366
116 (in isoform 2)Ubiquitination-4.39-
124UbiquitinationYVDAGAETMTQRLLK
EEECCCHHHHHHHHH		25.6127667366
135PhosphorylationRLLKRGETSGRVDDN
HHHHCCCCCCCCCCC		39.0315668135
136PhosphorylationLLKRGETSGRVDDNE
HHHCCCCCCCCCCCH		21.9422210690
145PhosphorylationRVDDNEETIKKRLET
CCCCCHHHHHHHHHH		31.7322210690
147 (in isoform 2)Ubiquitination-38.9822790023
147UbiquitinationDDNEETIKKRLETYY
CCCHHHHHHHHHHHH		38.9822790023
148 (in isoform 2)Ubiquitination-59.3622790023
148UbiquitinationDNEETIKKRLETYYN
CCHHHHHHHHHHHHC		59.3622790023
152PhosphorylationTIKKRLETYYNATEP
HHHHHHHHHHCCCCC		35.5850564315
153PhosphorylationIKKRLETYYNATEPV
HHHHHHHHHCCCCCE		5.8329514104
163UbiquitinationATEPVISFYDKRGIV
CCCCEEEEECCCCCE		6.6827667366
163 (in isoform 2)Ubiquitination-6.68-
164 (in isoform 2)Ubiquitination-17.48-
166 (in isoform 2)Ubiquitination-40.9422790023
166UbiquitinationPVISFYDKRGIVRKV
CEEEEECCCCCEEEE		40.9422790023
166AcetylationPVISFYDKRGIVRKV
CEEEEECCCCCEEEE		40.9421728379
171UbiquitinationYDKRGIVRKVNAEGT
ECCCCCEEEECCCCC		34.9727667366
181PhosphorylationNAEGTVDTVFSEVCT
CCCCCHHHHHHHHHH		21.0822210690
182 (in isoform 2)Ubiquitination-4.26-
184PhosphorylationGTVDTVFSEVCTYLD
CCHHHHHHHHHHHHH		25.4522210690
187S-nitrosylationDTVFSEVCTYLDSLK
HHHHHHHHHHHHHCC		1.4921278135
187S-nitrosocysteineDTVFSEVCTYLDSLK
HHHHHHHHHHHHHCC		1.49-
188PhosphorylationTVFSEVCTYLDSLK-
HHHHHHHHHHHHCC-		32.0922210690
192PhosphorylationEVCTYLDSLK-----
HHHHHHHHCC-----		35.1530991467
194AcetylationCTYLDSLK-------
HHHHHHCC-------		63.3519863703
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KAD1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KAD1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KAD1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of KAD1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KAD1_MOUSE

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Related Literatures of Post-Translational Modification

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