SAC1_HUMAN - dbPTM
SAC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAC1_HUMAN
UniProt AC Q9NTJ5
Protein Name Phosphatidylinositide phosphatase SAC1
Gene Name SACM1L
Organism Homo sapiens (Human).
Sequence Length 587
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). [PubMed: 24209621 Has low activity towards PtdIns(3,5)P2 (By similarity]
Protein Sequence MATAAYEQLKLHITPEKFYVEACDDGADDVLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLAYVLFWGVASIGTFFIILYNGKDFVDAPRLVQKEKID
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MATAAYEQLKLHI
--CCCHHHHHHHHCC		11.1827642862
10AcetylationTAAYEQLKLHITPEK
CHHHHHHHHCCCCHH		37.4025953088
45AcetylationTEVTLAVKKDVPPSA
CEEEEEEECCCCHHH		37.3325953088
101UbiquitinationDFDVLSYKKTMLHLT
CCHHHHHEEEEEEEE		38.09-
157PhosphorylationSPEFQEMSLLERADQ
CHHHHHHHHHHHHHH		29.1128857561
189UbiquitinationVHRFALPVLHGFITM
HHHHHHHHHHCCEEE		6.83-
205PhosphorylationSCSINGKYFDWILIS
EEEECCEEEEEEEEE		14.2520068231
212UbiquitinationYFDWILISRRSCFRA
EEEEEEEECHHHHHC		20.42-
212PhosphorylationYFDWILISRRSCFRA
EEEEEEEECHHHHHC		20.4220068231
230PhosphorylationYYVRGIDSEGHAANF
EEEECCCCCCCCCCE		43.4928270605
240PhosphorylationHAANFVETEQIVHYN
CCCCEEEEEEEEEEC		28.0828270605
250UbiquitinationIVHYNGSKASFVQTR
EEEECCCCEEEEEEC		49.82-
265PhosphorylationGSIPVFWSQRPNLKY
CCCCEEECCCCCCCC		12.5928857561
273UbiquitinationQRPNLKYKPLPQISK
CCCCCCCCCCCHHHH		38.19-
294PhosphorylationGFQRHFDSQVIIYGK
HHHHHCCCEEEEEEE		25.9623312004
342MalonylationYIAFDFHKECKNMRW
HHEEEHHHHHHCCCH		65.8726320211
362UbiquitinationLLDQVAEMQDELSYF
HHHHHHHCHHHHHEE		4.36-
386UbiquitinationANQEGVFRSNCMDCL
ECCCCCCCCCCHHHH		25.26-
387PhosphorylationNQEGVFRSNCMDCLD
CCCCCCCCCCHHHHC		23.9420068231
395UbiquitinationNCMDCLDRTNVIQSL
CCHHHHCHHHHHHHH		18.43-
396PhosphorylationCMDCLDRTNVIQSLL
CHHHHCHHHHHHHHH		33.2420068231
401PhosphorylationDRTNVIQSLLARRSL
CHHHHHHHHHHHHHH		17.7724076635
407PhosphorylationQSLLARRSLQAQLQR
HHHHHHHHHHHHHHH		21.1927174698
422UbiquitinationLGVLHVGQKLEEQDE
HCCCCCCCHHHCHHH		46.18-
423UbiquitinationGVLHVGQKLEEQDEF
CCCCCCCHHHCHHHH		52.52-
432UbiquitinationEEQDEFEKIYKNAWA
HCHHHHHHHHHHHHH		57.57-
432MethylationEEQDEFEKIYKNAWA
HCHHHHHHHHHHHHH		57.5766692039
435UbiquitinationDEFEKIYKNAWADNA
HHHHHHHHHHHHHHH		43.60-
447UbiquitinationDNANACAKQYAGTGA
HHHHHHHHHHCCCCC		43.66-
456UbiquitinationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.5819608861
456MalonylationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.5826320211
456AcetylationYAGTGALKTDFTRTG
HCCCCCCCCCCCCCC		45.5819608861
483UbiquitinationNSMIRYYKNNFSDGF
HHHHHHHHHCCCCCC		36.1621890473
483UbiquitinationNSMIRYYKNNFSDGF
HHHHHHHHHCCCCCC		36.1621890473
511PhosphorylationVDELESHSPLSVPRD
HHHHHHCCCCCCCCC		36.4929802988
514PhosphorylationLESHSPLSVPRDWKF
HHHCCCCCCCCCHHH		33.2024719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SAC1_HUMANSACM1Lphysical
14527956
COPA_HUMANCOPAphysical
14527956
COPB_HUMANCOPB1physical
14527956
COPE_HUMANCOPEphysical
14527956
COPG1_HUMANCOPG1physical
14527956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAC1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-456, AND MASS SPECTROMETRY.

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