ENTP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENTP7_HUMAN
• UniProt AC: Q9NQZ7
• Protein Name: Ectonucleoside triphosphate diphosphohydrolase 7
• Gene Name: ENTPD7
• Organism: Homo sapiens (Human).
• Sequence Length: 604
• Subcellular Localization: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Localizes to intracellular vesicular compartments.
• Protein Description: Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP..
• Protein Sequence: MARISFSYLCPASWYFTVPTVSPFLRQRVAFLGLFFISCLLLLMLIIDFRHWSASLPRDRQYERYLARVGELEATDTEDPNLNYGLVVDCGSSGSRIFVYFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPEHASDYLRPLLSFAAAHVPVKKHKETPLYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGKQEGVYAWIGINFVLGRFDHEDESDAEATQELAAGRRRTVGILDMGGASLQIAYEVPTSTSVLPAKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDLVLNETLNKNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWVSCGAMLSPLLARSNTSQASLNGIYQSPIDFNNSEFYGFSEFFYCTEDVLRIGGRYHGPTFAKAAQDYCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFPYDYPNLRTAQLVYDREVQWTLGAILYKTRFLPLRDLRQEGVRQAHGSWFRLSFVYNHYLFFACILVVLLAIFLYLLRLRRIHHRQTRASAPLDLLWLEEVVPMMGVQVGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MARISFSYLCPA ---CCCEEEEEECCC	11.55	25002506
7	Phosphorylation	-MARISFSYLCPASW -CCCEEEEEECCCEE	15.48	25002506
8	Phosphorylation	MARISFSYLCPASWY CCCEEEEEECCCEEE	15.43	25002506
13	Phosphorylation	FSYLCPASWYFTVPT EEEECCCEEEEECCC	13.88	25002506
15	Phosphorylation	YLCPASWYFTVPTVS EECCCEEEEECCCCC	6.20	25002506
17	Phosphorylation	CPASWYFTVPTVSPF CCCEEEEECCCCCHH	15.18	25002506
20	Phosphorylation	SWYFTVPTVSPFLRQ EEEEECCCCCHHHHH	29.31	25002506
22	Phosphorylation	YFTVPTVSPFLRQRV EEECCCCCHHHHHHH	16.65	25002506
55	Phosphorylation	DFRHWSASLPRDRQY HHHHHHHCCCCHHHH	33.13	24719451
128	Ubiquitination	RNSQPVVKKIKPGIS CCCCCCHHHCCCCCC	49.36	27667366
140	O-linked_Glycosylation	GISAMADTPEHASDY CCCCCCCCHHHHHHH	22.49	30379171
167	Phosphorylation	PVKKHKETPLYILCT CCCCCCCCCEEEEEC	24.32	-
170	Phosphorylation	KHKETPLYILCTAGM CCCCCCEEEEECCCC	7.95	-
174	Phosphorylation	TPLYILCTAGMRLLP CCEEEEECCCCCCCH	23.85	-
253	Phosphorylation	LAAGRRRTVGILDMG HHHHCCCEEEEEECC	22.67	24425749
274	Phosphorylation	AYEVPTSTSVLPAKQ EEECCCCCCCCCCCH	25.90	24425749
275	O-linked_Glycosylation	YEVPTSTSVLPAKQE EECCCCCCCCCCCHH	22.79	OGP
330	N-linked_Glycosylation	RYEDLVLNETLNKNR HHHHHHHHHHCCCCC	32.50	UniProtKB CARBOHYD
342	Ubiquitination	KNRLLGQKTGLSPDN CCCCCCCCCCCCCCC	42.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENTP7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENTP7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENTP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPP2B_HUMAN	SPPL2B	physical	28514442
UBP32_HUMAN	USP32	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
LAP4B_HUMAN	LAPTM4B	physical	28514442
JMJD8_HUMAN	JMJD8	physical	28514442
NMU_HUMAN	NMU	physical	28514442
GLP3L_HUMAN	GOLPH3L	physical	28514442
NFIP1_HUMAN	NDFIP1	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
PGK2_HUMAN	PGK2	physical	28514442
C43BP_HUMAN	COL4A3BP	physical	28514442
GOLP3_HUMAN	GOLPH3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.