NMU_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMU_HUMAN
• UniProt AC: P48645
• Protein Name: Neuromedin-U
• Gene Name: NMU
• Organism: Homo sapiens (Human).
• Sequence Length: 174
• Subcellular Localization: Secreted.
• Protein Description: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder..
• Protein Sequence: MLRTESCRPRSPAGQVAAASPLLLLLLLLAWCAGACRGAPILPQGLQPEQQLQLWNEIDDTCSSFLSIDSQPQASNALEELCFMIMGMLPKPQEQDEKDNTKRFLFHYSKTQKLGKSNVVSSVVHPLLQLVPHLHERRMKRFRVDEEFQSPFASQSRGYFLFRPRNGRRSAGFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	O-linked_Glycosylation	KRFLFHYSKTQKLGK HHHEEEHHHHHCCCC	22.21	55833227
139	Oxidation	PHLHERRMKRFRVDE HHHHHHHHHHHCCCH	4.59	-
166	Asparagine amide	YFLFRPRNGRRSAGF EEEECCCCCCCCCCC	51.51	-
166	Amidation	YFLFRPRNGRRSAGF EEEECCCCCCCCCCC	51.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMU_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMU_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMU_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NMUR1_HUMAN	NMUR1	physical	10894543
NMUR2_HUMAN	NMUR2	physical	10894543
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.