| UniProt ID | ERGI2_HUMAN | |
|---|---|---|
| UniProt AC | Q96RQ1 | |
| Protein Name | Endoplasmic reticulum-Golgi intermediate compartment protein 2 | |
| Gene Name | ERGIC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 377 | |
| Subcellular Localization |
Endoplasmic reticulum-Golgi intermediate compartment membrane Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane Multi-pass membrane protein. Endoplasmic reticulum membrane Multi-pass membrane protein. Cytoplasm. Nucleus. Cyc |
|
| Protein Description | Possible role in transport between endoplasmic reticulum and Golgi.. | |
| Protein Sequence | MRRLNRKKTLSLVKELDAFPKVPESYVETSASGGTVSLIAFTTMALLTIMEFSVYQDTWMKYEYEVDKDFSSKLRINIDITVAMKCQYVGADVLDLAETMVASADGLVYEPTVFDLSPQQKEWQRMLQLIQSRLQEEHSLQDVIFKSAFKSTSTALPPREDDSSQSPNACRIHGHLYVNKVAGNFHITVGKAIPHPRGHAHLAALVNHESYNFSHRIDHLSFGELVPAIINPLDGTEKIAIDHNQMFQYFITVVPTKLHTYKISADTHQFSVTERERIINHAAGSHGVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGIVGGIFSTTGMLHGIGKFIVEIICCRFRLGSYKPVNSVPFEDGHTDNHLPLLENNTH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | RRLNRKKTLSLVKEL CCCCHHHHHHHHHHH | 25.31 | 20873877 | |
| 11 | Phosphorylation | LNRKKTLSLVKELDA CCHHHHHHHHHHHCC | 36.03 | 22617229 | |
| 14 | Ubiquitination | KKTLSLVKELDAFPK HHHHHHHHHHCCCCC | 58.83 | 21890473 | |
| 23 | Ubiquitination | LDAFPKVPESYVETS HCCCCCCCHHHEEEC | 30.83 | 21890473 | |
| 68 | Ubiquitination | KYEYEVDKDFSSKLR EEEEEECCCCHHCEE | 66.89 | - | |
| 109 | Phosphorylation | ASADGLVYEPTVFDL HCCCCCEECCEECCC | 22.64 | 24275569 | |
| 126 | Sulfoxidation | QQKEWQRMLQLIQSR HHHHHHHHHHHHHHH | 1.35 | 21406390 | |
| 139 | Phosphorylation | SRLQEEHSLQDVIFK HHHHHHHCHHHHHHH | 30.88 | 24260401 | |
| 146 | Ubiquitination | SLQDVIFKSAFKSTS CHHHHHHHHHHHCCC | 29.74 | 21890473 | |
| 150 | Ubiquitination | VIFKSAFKSTSTALP HHHHHHHHCCCCCCC | 53.17 | - | |
| 154 | O-linked_Glycosylation | SAFKSTSTALPPRED HHHHCCCCCCCCCCC | 32.10 | 55833053 | |
| 155 | Ubiquitination | AFKSTSTALPPREDD HHHCCCCCCCCCCCC | 20.17 | 21890473 | |
| 177 | Phosphorylation | CRIHGHLYVNKVAGN EEEECEEEEEEECCC | 9.05 | - | |
| 262 | Ubiquitination | PTKLHTYKISADTHQ CCCEEEEEEECCCCC | 31.19 | - | |
| 264 | Phosphorylation | KLHTYKISADTHQFS CEEEEEEECCCCCCC | 18.88 | 26126808 | |
| 267 | Phosphorylation | TYKISADTHQFSVTE EEEEECCCCCCCCHH | 19.79 | 26126808 | |
| 271 | Phosphorylation | SADTHQFSVTERERI ECCCCCCCCHHHHHH | 22.89 | 26126808 | |
| 273 | Phosphorylation | DTHQFSVTERERIIN CCCCCCCHHHHHHHH | 28.29 | 26126808 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERGI2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERGI2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERGI2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ERGI2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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