GPC5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPC5B_HUMAN
• UniProt AC: Q9NZH0
• Protein Name: G-protein coupled receptor family C group 5 member B
• Gene Name: GPRC5B
• Organism: Homo sapiens (Human).
• Sequence Length: 403
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Localized in the plasma membrane and perinuclear vesicles.
• Protein Description: Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways..
• Protein Sequence: MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MFVASERKMRAH ---CCCCCHHHHHHH	32.41	20363803
16	Phosphorylation	MRAHQVLTFLLLFVI HHHHHHHHHHHHHHH	17.24	-
30	N-linked_Glycosylation	ITSVASENASTSRGC HHHHHCCCCCCCCCC	36.37	UniProtKB CARBOHYD
307	Phosphorylation	LQENTPNYFDTSQPR HHHCCCCCCCCCCHH	12.20	29759185
311	Phosphorylation	TPNYFDTSQPRMRET CCCCCCCCCHHHHHH	39.78	29759185
318	Phosphorylation	SQPRMRETAFEEDVQ CCHHHHHHHHHHHCC	26.70	29759185
330	Phosphorylation	DVQLPRAYMENKAFS HCCCCHHHHHCCCCC	13.26	29759185
334	Ubiquitination	PRAYMENKAFSMDEH CHHHHHCCCCCHHHH	37.19	21890473
337	Phosphorylation	YMENKAFSMDEHNAA HHHCCCCCHHHHHHH	30.13	27422710
347	Phosphorylation	EHNAALRTAGFPNGS HHHHHHHHCCCCCCC	31.79	18510355
354	Phosphorylation	TAGFPNGSLGKRPSG HCCCCCCCCCCCCCC	40.36	28188228
360	Ubiquitination	GSLGKRPSGSLGKRP CCCCCCCCCCCCCCC	45.08	21890473
360	Phosphorylation	GSLGKRPSGSLGKRP CCCCCCCCCCCCCCC	45.08	29691806
362	Phosphorylation	LGKRPSGSLGKRPSA CCCCCCCCCCCCCCC	37.98	28102081
368	Phosphorylation	GSLGKRPSAPFRSNV CCCCCCCCCCCCCCC	53.24	28857561
373	Phosphorylation	RPSAPFRSNVYQPTE CCCCCCCCCCCCCCC	30.90	26356563
373 (in isoform 2)	Phosphorylation	-	30.90	25072903
376	Phosphorylation	APFRSNVYQPTEMAV CCCCCCCCCCCCEEE	17.02	27259358
376 (in isoform 2)	Phosphorylation	-	17.02	25072903
379	Phosphorylation	RSNVYQPTEMAVVLN CCCCCCCCCEEEEEC	23.91	26356563
379 (in isoform 2)	Phosphorylation	-	23.91	25072903
389	Phosphorylation	AVVLNGGTIPTAPPS EEEECCCCCCCCCCC	25.78	26356563
389 (in isoform 2)	Phosphorylation	-	25.78	25072903
393 (in isoform 2)	Phosphorylation	-	14.51	25072903
396	Phosphorylation	TIPTAPPSHTGRHLW CCCCCCCCCCCCCCC	32.40	26356563
398	Phosphorylation	PTAPPSHTGRHLW-- CCCCCCCCCCCCC--	40.00	26356563

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPC5B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPC5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPC5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPP7_HUMAN	MPP7	physical	28514442
STXB1_HUMAN	STXBP1	physical	28514442
STX4_HUMAN	STX4	physical	28514442
SDCB1_HUMAN	SDCBP	physical	28514442
SEC63_HUMAN	SEC63	physical	28514442
STXB3_HUMAN	STXBP3	physical	28514442
ATPB_HUMAN	ATP5B	physical	28514442
DLG1_HUMAN	DLG1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.