TPC1_HUMAN - dbPTM
TPC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPC1_HUMAN
UniProt AC Q9ULQ1
Protein Name Two pore calcium channel protein 1
Gene Name TPCN1
Organism Homo sapiens (Human).
Sequence Length 816
Subcellular Localization Lysosome membrane
Multi-pass membrane protein . Endosome membrane
Multi-pass membrane protein .
Protein Description Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane..
Protein Sequence MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationLGQEELPSKNGGSYA
CCCCCCCCCCCCCEE		51.9124719451
56 (in isoform 3)Phosphorylation-33.2928796482
58 (in isoform 3)Phosphorylation-51.3128796482
59 (in isoform 3)Phosphorylation-25.2125849741
62 (in isoform 3)Phosphorylation-29.5028796482
92UbiquitinationDKFFTHPKDAKALAA
CCCCCCHHHHHHHHH		63.81-
3382-HydroxyisobutyrylationFKSLLLHKRTAIQHA
HHHHHHHHHHHHHHH		51.95-
351PhosphorylationHAYRLLISQRRPAGI
HHHHHHHHCCCCCCC		20.0124719451
354MethylationRLLISQRRPAGISYR
HHHHHCCCCCCCCHH		20.13115918777
361MethylationRPAGISYRQFEGLMR
CCCCCCHHHHHHHHH		28.11115918781
382PhosphorylationSARERYLTFKALNQN
CHHHHHHHHHHHCCC		17.73-
391PhosphorylationKALNQNNTPLLSLKD
HHHCCCCCCCCCHHH		23.9030619164
395PhosphorylationQNNTPLLSLKDFYDI
CCCCCCCCHHHHHHH		40.8424719451
426PhosphorylationWFDELPRTALLIFKG
HCHHCCHHHHHHHCC		21.51-
448PhosphorylationKAFQYFMYLVVAVNG
HHHHHHHHHHHHHHC		6.0922210691
569PhosphorylationELLPRMASLGLTLLI
HHHHHHHHHHHHHHH		17.39-
573PhosphorylationRMASLGLTLLIFYYS
HHHHHHHHHHHHHHH		20.09-
599N-linked_GlycosylationIVFPNCCNTSTVADA
CCCCCCCCCCHHHHH		38.98UniProtKB CARBOHYD
611N-linked_GlycosylationADAYRWRNHTVGNRT
HHHHHHCCCCCCCCE		28.37UniProtKB CARBOHYD
616N-linked_GlycosylationWRNHTVGNRTVVEEG
HCCCCCCCCEEEECC		31.92UniProtKB CARBOHYD
764PhosphorylationFLGRRSRTKSDLSLK
CCCCCCCCCCHHHHH		35.8329396449
766PhosphorylationGRRSRTKSDLSLKMY
CCCCCCCCHHHHHHH		43.0723911959
769PhosphorylationSRTKSDLSLKMYQEE
CCCCCHHHHHHHHHH		30.8229396449
795PhosphorylationQEQQRQLSSSAAPAA
HHHHHHHHHCCCCHH		17.5723911959
796PhosphorylationEQQRQLSSSAAPAAQ
HHHHHHHHCCCCHHH		32.3728450419
797PhosphorylationQQRQLSSSAAPAAQQ
HHHHHHHCCCCHHHC		25.6928450419
808PhosphorylationAAQQPPGSRQRSQTV
HHHCCCCCCCCCCCC		30.8925159151
812PhosphorylationPPGSRQRSQTVT---
CCCCCCCCCCCC---		23.12-
814PhosphorylationGSRQRSQTVT-----
CCCCCCCCCC-----		27.62-
816PhosphorylationRQRSQTVT-------
CCCCCCCC-------		35.9628655764
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TPC1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPC1_HUMAN

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Related Literatures of Post-Translational Modification

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