TMPPE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMPPE_HUMAN
• UniProt AC: Q6ZT21
• Protein Name: Transmembrane protein with metallophosphoesterase domain
• Gene Name: TMPPE
• Organism: Homo sapiens (Human).
• Sequence Length: 453
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAIFRQLSLGAKATLAAVTVFVSMIASRSYLAESLELRAWRWLLRLQLALFVNSLLLIGSLYIWRSTVSNLCHSPAAESTCFQLWKVVVLAFLALAHSSFFTMFFLVAEEPYLFSLAAYSCLGAYIIMLFFLFILSGMEQAYQLLAWRSGRVVGSLEKTRKLVLRPALAVGVTAVLSVAGILNAAQPPAVKTVEVPIHQLPASMNNLKIVLLSDIHLGPTVGRTKMEMFVRMVNVLEPDITVIVGDLSDSEASVLRTAVAPLGQLHSHLGAYFVTGNHEYYTSDVSNWFALLESLHVQPLHNENVKISATRAQRGGGGSGSGSEDEDWICLAGVDDIEADILHYSGHGMDLDKALEGCSPDHTIILLAHQPLAAKRALQARPDINLILSGHTHAGQIFPLNVAAYLLNPFFAGLYQVAQATFVYVSPGTAYYGIPMRLGSRAEITELILQRSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	TLAAVTVFVSMIASR HHHHHHHHHHHHHCC	2.16	33845483
34	Phosphorylation	SRSYLAESLELRAWR CCHHHHHHHHHHHHH	22.87	24719451
62	Phosphorylation	LLLIGSLYIWRSTVS HHHHHHHHHHHHHHH	10.51	-
158	Ubiquitination	RVVGSLEKTRKLVLR CCEECHHHHHHHHHH	59.95	33845483
225	Acetylation	GPTVGRTKMEMFVRM CCCCCHHHHHHHHHH	31.35	19826885

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMPPE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMPPE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMPPE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMPPE_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.