| UniProt ID | PIGO_HUMAN | |
|---|---|---|
| UniProt AC | Q8TEQ8 | |
| Protein Name | GPI ethanolamine phosphate transferase 3 | |
| Gene Name | PIGO | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1089 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.. | |
| Protein Sequence | MQKASVLLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVVLVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEIQPHHARLYRSQVDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAIVEDNLIKQLTSAGRRVVFMGDDTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKHGPHHPEMAKKLSQMDQVIQGLVERLENDTLLVVAGDHGMTTNGDHGGDSELEVSAALFLYSPTAVFPSTPPEEPEVIPQVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDSQPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLLQSPKGAEATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPFCPLLLTPVAWGLVGAIAYAGLLGTIELKLDLVLLGAVAAVSSFLPFLWKAWAGWGSKRPLATLFPIPGPVLLLLLFRLAVFFSDSFVVAEARATPFLLGSFILLLVVQLHWEGQLLPPKLLTMPRLGTSATTNPPRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGGRAKNLWYGACVAALVALLAAVRLWLRRYGNLKSPEPPMLFVRWGLPLMALGTAAYWALASGADEAPPRLRVLVSGASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPFSGPPTSQADLDYVVPQIYRHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMVTALTLLAFPLLLLHAERISLVFLLLFLQSFLLLHLLAAGIPVTTPGPFTVPWQAVSAWALMATQTFYSTGHQPVFPAIHWHAAFVGFPEGHGSCTWLPALLVGANTFASHLLFAVGCPLLLLWPFLCESQGLRKRQQPPGNEADARVRPEEEEEPLMEMRLRDAPQHFYAALLQLGLKYLFILGIQILACALAASILRRHLMVWKVFAPKFIFEAVGFIVSSVGLLLGIALVMRVDGAVSSWFRQLFLAQQR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 103 (in isoform 2) | Ubiquitination | - | 47.55 | 21890473 | |
| 103 (in isoform 1) | Ubiquitination | - | 47.55 | 21890473 | |
| 103 | Ubiquitination | VSLPFLGKLSSLQRI CCCCHHHHHHHHHHH | 47.55 | 22817900 | |
| 121 | Phosphorylation | QPHHARLYRSQVDPP CCCCHHHHHCCCCCC | 11.58 | 27174698 | |
| 123 | Phosphorylation | HHARLYRSQVDPPTT CCHHHHHCCCCCCCC | 22.46 | 27174698 | |
| 129 | Phosphorylation | RSQVDPPTTTMQRLK HCCCCCCCCHHHHHH | 40.04 | 22210691 | |
| 130 | Phosphorylation | SQVDPPTTTMQRLKA CCCCCCCCHHHHHHH | 26.50 | 27174698 | |
| 131 | Phosphorylation | QVDPPTTTMQRLKAL CCCCCCCHHHHHHHH | 17.49 | 27174698 | |
| 136 | Ubiquitination | TTTMQRLKALTTGSL CCHHHHHHHHHHCCC | 43.47 | 21963094 | |
| 181 | Phosphorylation | VVFMGDDTWKDLFPG EEEECCCCHHHHCCC | 38.87 | 30576142 | |
| 192 | Ubiquitination | LFPGAFSKAFFFPSF HCCCHHHHCEECCCC | 42.64 | 33845483 | |
| 251 (in isoform 2) | Ubiquitination | - | 43.78 | 21890473 | |
| 251 (in isoform 1) | Ubiquitination | - | 43.78 | 21890473 | |
| 251 | Ubiquitination | HHPEMAKKLSQMDQV CCHHHHHHHHHHHHH | 43.78 | 2190698 | |
| 253 | Phosphorylation | PEMAKKLSQMDQVIQ HHHHHHHHHHHHHHH | 32.13 | 24719451 | |
| 268 | N-linked_Glycosylation | GLVERLENDTLLVVA HHHHHHHCCCEEEEE | 52.76 | UniProtKB CARBOHYD | |
| 391 | Ubiquitination | ATQDLQAKELHQLQN HHHHHHHHHHHHHHH | 48.09 | 21963094 | |
| 401 | Phosphorylation | HQLQNLFSKASADYQ HHHHHHHHHHCCCHH | 30.40 | 24719451 | |
| 402 | Ubiquitination | QLQNLFSKASADYQW HHHHHHHHHCCCHHH | 38.74 | 21963094 | |
| 413 | Phosphorylation | DYQWLLQSPKGAEAT CHHHHHCCCCCHHCC | 28.66 | 26091039 | |
| 601 | Phosphorylation | LLPPKLLTMPRLGTS CCCHHHCCCCCCCCC | 35.25 | 24719451 | |
| 695 | Ubiquitination | LRRYGNLKSPEPPML HHHHCCCCCCCCCEE | 68.88 | 21963094 | |
| 696 | Phosphorylation | RRYGNLKSPEPPMLF HHHCCCCCCCCCEEH | 37.35 | 27251275 | |
| 737 | Phosphorylation | PRLRVLVSGASMVLP CCEEEEECCHHCHHH | 25.20 | - | |
| 768 | Ubiquitination | KPVTVLVKAGAGAPR CCEEEEEECCCCCCC | 36.62 | - | |
| 781 | Phosphorylation | PRTRTVLTPFSGPPT CCCEEEECCCCCCCC | 20.25 | 28796482 | |
| 784 | Phosphorylation | RTVLTPFSGPPTSQA EEEECCCCCCCCCHH | 52.15 | 28796482 | |
| 788 | Phosphorylation | TPFSGPPTSQADLDY CCCCCCCCCHHHHHH | 36.28 | 28796482 | |
| 789 | Phosphorylation | PFSGPPTSQADLDYV CCCCCCCCHHHHHHH | 29.19 | 28796482 | |
| 795 | Phosphorylation | TSQADLDYVVPQIYR CCHHHHHHHHHHHHH | 15.62 | 28796482 | |
| 801 | Phosphorylation | DYVVPQIYRHMQEEF HHHHHHHHHHHHHHH | 6.82 | 28796482 | |
| 1016 | Phosphorylation | LLQLGLKYLFILGIQ HHHHHHHHHHHHHHH | 16.34 | - | |
| 1032 | Phosphorylation | LACALAASILRRHLM HHHHHHHHHHHHHHH | 19.29 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PIGO_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIGO_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIGO_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| POTEI_HUMAN | POTEI | physical | 28514442 | |
| AT2A3_HUMAN | ATP2A3 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614749 | Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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