RTN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RTN2_HUMAN
• UniProt AC: O75298
• Protein Name: Reticulon-2
• Gene Name: RTN2
• Organism: Homo sapiens (Human).
• Sequence Length: 545
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Sequence: MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFSEEDEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSTARRPRPQGRSVSEPRDQHPQPSLGDSLESIPSLSQSPEPGRRGDPDTAPPSERPLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLKTSLLLAVYKTVPILELSPPLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSGVPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPGTGALASAAAAVSGSKAKAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	LHTAREFSEEDEEET HHHHHCCCHHHCCCC	35.01	15345747
94	Phosphorylation	RPQGRSVSEPRDQHP CCCCCCCCCCCCCCC	43.03	24719451
104	Phosphorylation	RDQHPQPSLGDSLES CCCCCCCCCCCCHHH	39.47	27732954
108	Phosphorylation	PQPSLGDSLESIPSL CCCCCCCCHHHCCCC	32.03	27732954
111	Phosphorylation	SLGDSLESIPSLSQS CCCCCHHHCCCCCCC	45.13	27732954
114	Phosphorylation	DSLESIPSLSQSPEP CCHHHCCCCCCCCCC	38.70	27732954
116	Phosphorylation	LESIPSLSQSPEPGR HHHCCCCCCCCCCCC	32.71	27732954
118	Phosphorylation	SIPSLSQSPEPGRRG HCCCCCCCCCCCCCC	28.05	27732954
181	Phosphorylation	QEPNRLETGEAGEEL CCCCCCCCCCCCCHH	44.93	-
198	Phosphorylation	RLRLAQPSSPEVLTP HECCCCCCCCCCCCC	46.58	25022875
199	Phosphorylation	LRLAQPSSPEVLTPQ ECCCCCCCCCCCCCC	31.59	25022875
204	Phosphorylation	PSSPEVLTPQLSPGS CCCCCCCCCCCCCCC	17.73	25022875
208	Phosphorylation	EVLTPQLSPGSGTPQ CCCCCCCCCCCCCCC	23.20	27732954
211	Phosphorylation	TPQLSPGSGTPQAGT CCCCCCCCCCCCCCC	42.76	27732954
213	Phosphorylation	QLSPGSGTPQAGTPS CCCCCCCCCCCCCCC	17.58	27732954
218	Phosphorylation	SGTPQAGTPSPSRSR CCCCCCCCCCCCCCC	24.49	27732954
220	Phosphorylation	TPQAGTPSPSRSRDS CCCCCCCCCCCCCCC	35.03	27732954
222	Phosphorylation	QAGTPSPSRSRDSNS CCCCCCCCCCCCCCC	47.42	27732954
224	Phosphorylation	GTPSPSRSRDSNSGP CCCCCCCCCCCCCCC	44.79	27732954
227	Phosphorylation	SPSRSRDSNSGPEEP CCCCCCCCCCCCCCC	31.61	27732954
229	Phosphorylation	SRSRDSNSGPEEPLL CCCCCCCCCCCCCCC	60.73	27732954
258	Phosphorylation	VRGQCLDSTDQLEFT CCCCCCCCCCCEEEE	22.42	-
273	Phosphorylation	VEPRLLGTAMEWLKT ECHHHHHHHHHHHHH	23.85	22210691
280	Phosphorylation	TAMEWLKTSLLLAVY HHHHHHHHHHHHHHH	23.57	22210691
281	Phosphorylation	AMEWLKTSLLLAVYK HHHHHHHHHHHHHHH	18.55	22210691
289	Phosphorylation	LLLAVYKTVPILELS HHHHHHHHCCHHHCC	17.52	-
343	Phosphorylation	SLGADMGSKVADLLY EECCCCCCHHHHHHH	19.81	26552605
350	Phosphorylation	SKVADLLYWKDTRTS CHHHHHHHHCCCCCC	20.08	26552605
354	Phosphorylation	DLLYWKDTRTSGVVF HHHHHCCCCCCCCHH	31.92	26552605
436	Phosphorylation	ERLSHQITSRVVSAA HHHHHHHHHHHHHHH	12.15	28509920
437	Phosphorylation	RLSHQITSRVVSAAT HHHHHHHHHHHHHHH	25.38	28509920
441	Phosphorylation	QITSRVVSAATQLRH HHHHHHHHHHHHHHH	14.88	26437602
527	Phosphorylation	IRAKIPGTGALASAA HHHCCCCCHHHHHHH	17.58	-
532	Phosphorylation	PGTGALASAAAAVSG CCCHHHHHHHHHHHC	21.20	-
538	Phosphorylation	ASAAAAVSGSKAKAE HHHHHHHHCHHHCCC	32.40	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RTN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RTN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RTN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JPH1_HUMAN	JPH1	physical	26186194
MCRS1_HUMAN	MCRS1	physical	26186194
TNKS1_HUMAN	TNKS	physical	26186194
TNKS1_HUMAN	TNKS	physical	28514442
JPH1_HUMAN	JPH1	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604805: Spastic paraplegia 12, autosomal dominant (SPG12)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.