ENPP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENPP2_HUMAN
• UniProt AC: Q13822
• Protein Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
• Gene Name: ENPP2
• Organism: Homo sapiens (Human).
• Sequence Length: 863
• Subcellular Localization: Secreted .
• Protein Description: Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. [PubMed: 15769751]
• Protein Sequence: MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLHTYESEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	LSDSPWTNISGSCKG CCCCCCCCCCCCCCC	23.66	UniProtKB CARBOHYD
82	Phosphorylation	RCDNLCKSYTSCCHD CCCCHHHHHHHHCCC	32.42	-
83	Phosphorylation	CDNLCKSYTSCCHDF CCCHHHHHHHHCCCH	6.54	-
84	Phosphorylation	DNLCKSYTSCCHDFD CCHHHHHHHHCCCHH	23.52	-
85	Phosphorylation	NLCKSYTSCCHDFDE CHHHHHHHHCCCHHH	13.40	-
210	Phosphorylation	RPVYPTKTFPNLYTL CCCCCCCCCCCHHHH	46.96	8798697
288	Phosphorylation	PHERRILTILQWLTL CHHHHHHHHHHHHCC	19.78	-
302	Phosphorylation	LPDHERPSVYAFYSE CCCCCCCCEEEEECC	33.70	-
308	Phosphorylation	PSVYAFYSEQPDFSG CCEEEEECCCCCCCC	24.25	-
370	Phosphorylation	EDVTCDRTEFLSNYL CCCCCCHHHHHHHHC	20.17	-
378	Phosphorylation	EFLSNYLTNVDDITL HHHHHHCCCCHHHEE	23.88	-
411	N-linked_Glycosylation	DPKAIIANLTCKKPD CHHHEEEECCCCCCC	26.02	UniProtKB CARBOHYD
413	Phosphorylation	KAIIANLTCKKPDQH HHEEEECCCCCCCCC	23.30	23312004
462	Phosphorylation	ARKPLDVYKKPSGKC CCCCCCCCCCCCCCE	16.98	-
525	N-linked_Glycosylation	GLKPAPNNGTHGSLN CCCCCCCCCCCCCHH	56.53	26371182
596 (in isoform 3)	Phosphorylation	-	24.38	-
599	Phosphorylation	TEERHLLYGRPAVLY HHHHHHHHCCCEEEE	19.90	-
606	Phosphorylation	YGRPAVLYRTRYDIL HCCCEEEEEECCEEE	11.88	-
694	Phosphorylation	SSSPEAKYDAFLVTN CCCCCHHHCEEEECC	21.39	-
807	N-linked_Glycosylation	PDNEESCNSSEDESK CCCHHHCCCCHHHHH	58.82	UniProtKB CARBOHYD
835	Phosphorylation	RDIEHLTSLDFFRKT HCHHHHHHHHHHHHH	32.09	22617229
846	Phosphorylation	FRKTSRSYPEILTLK HHHHCCCCCCHHHHH	12.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ENPP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENPP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENPP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB4_HUMAN	ITGB4	physical	21696367
LPAR1_HUMAN	LPAR1	physical	21696367

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.