MFSD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFSD5_HUMAN
• UniProt AC: Q6N075
• Protein Name: Molybdate-anion transporter
• Gene Name: MFSD5
• Organism: Homo sapiens (Human).
• Sequence Length: 450
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum..
• Protein Sequence: MLVTAYLAFVGLLASCLGLELSRCRAKPPGRACSNPSFLRFQLDFYQVYFLALAADWLQAPYLYKLYQHYYFLEGQIAILYVCGLASTVLFGLVASSLVDWLGRKNSCVLFSLTYSLCCLTKLSQDYFVLLVGRALGGLSTALLFSAFEAWYIHEHVERHDFPAEWIPATFARAAFWNHVLAVVAGVAAEAVASWIGLGPVAPFVAAIPLLALAGALALRNWGENYDRQRAFSRTCAGGLRCLLSDRRVLLLGTIQALFESVIFIFVFLWTPVLDPHGAPLGIIFSSFMAASLLGSSLYRIATSKRYHLQPMHLLSLAVLIVVFSLFMLTFSTSPGQESPVESFIAFLLIELACGLYFPSMSFLRRKVIPETEQAGVLNWFRVPLHSLACLGLLVLHDSDRKTGTRNMFSICSAVMVMALLAVVGLFTVVRHDAELRVPSPTEEPYAPEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	AFVGLLASCLGLELS HHHHHHHHHHCHHHH	15.16	-
22	Phosphorylation	SCLGLELSRCRAKPP HHHCHHHHHHCCCCC	21.69	-
107 (in isoform 2)	Phosphorylation	-	14.50	-
111 (in isoform 2)	Phosphorylation	-	2.54	27642862
113 (in isoform 2)	Phosphorylation	-	4.00	27642862
129 (in isoform 2)	Phosphorylation	-	3.08	27642862
236	S-palmitoylation	QRAFSRTCAGGLRCL HHHHHHHHHHHHHHH	3.00	29575903
242	S-palmitoylation	TCAGGLRCLLSDRRV HHHHHHHHHHCCCCH	5.58	29575903
367	Ubiquitination	SMSFLRRKVIPETEQ CHHHHHHCCCCHHHH	37.77	22817900
367 (in isoform 1)	Ubiquitination	-	37.77	21890473
440	Phosphorylation	DAELRVPSPTEEPYA CCCCCCCCCCCCCCC	41.41	25849741
442	Phosphorylation	ELRVPSPTEEPYAPE CCCCCCCCCCCCCCC	58.27	30266825
446	Phosphorylation	PSPTEEPYAPEL--- CCCCCCCCCCCC---	37.76	29978859
474	Ubiquitination	------------------------------- -------------------------------		21890473
547 (in isoform 2)	Phosphorylation	-		24719451
553 (in isoform 2)	Phosphorylation	-		27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFSD5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFSD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFSD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX19_HUMAN	PEX19	physical	21988832
CR3L1_HUMAN	CREB3L1	physical	25416956
KASH5_HUMAN	CCDC155	physical	25416956
CR3L1_HUMAN	CREB3L1	physical	21516116
G3PT_HUMAN	GAPDHS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.