TM87B_HUMAN - dbPTM
TM87B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TM87B_HUMAN
UniProt AC Q96K49
Protein Name Transmembrane protein 87B {ECO:0000305}
Gene Name TMEM87B {ECO:0000312|HGNC:HGNC:25913}
Organism Homo sapiens (Human).
Sequence Length 555
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein .
Protein Description May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)..
Protein Sequence MVAACRSVAGLLPRRRRCFPARAPLLRVALCLLCWTPAAVRAVPELGLWLETVNDKSGPLIFRKTMFNSTDIKLSVKSFHCSGPVKFTIVWHLKYHTCHNEHSNLEELFQKHKLSVDEDFCHYLKNDNCWTTKNENLDCNSDSQVFPSLNNKELINIRNVSNQERSMDVVARTQKDGFHIFIVSIKTENTDASWNLNVSLSMIGPHGYISASDWPLMIFYMVMCIVYILYGILWLTWSACYWKDILRIQFWIAAVIFLGMLEKAVFYSEYQNISNTGLSTQGLLIFAELISAIKRTLARLLVIIVSLGYGIVKPRLGTVMHRVIGLGLLYLIFAAVEGVMRVIGGSNHLAVVLDDIILAVIDSIFVWFIFISLAQTMKTLRLRKNTVKFSLYRHFKNTLIFAVLASIVFMGWTTKTFRIAKCQSDWMERWVDDAFWSFLFSLILIVIMFLWRPSANNQRYAFMPLIDDSDDEIEEFMVTSENLTEGIKLRASKSVSNGTAKPATSENFDEDLKWVEENIPSSFTDVALPVLVDSDEEIMTRSEMAEKMFSSEKIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MVAACRSVAGLLPR
-CHHHHHHHHCCCCC		19.0624043423
68N-linked_GlycosylationIFRKTMFNSTDIKLS
EEEEECCCCCCEEEE		32.93UniProtKB CARBOHYD
111UbiquitinationNLEELFQKHKLSVDE
CHHHHHHHHCCCCCH		35.0629967540
113UbiquitinationEELFQKHKLSVDEDF
HHHHHHHCCCCCHHH		49.8729967540
197N-linked_GlycosylationTDASWNLNVSLSMIG
CCCCEEEEEEEEEEC		20.37UniProtKB CARBOHYD
268PhosphorylationLEKAVFYSEYQNISN
HHHHHHHHHHCCCCC		20.54-
272N-linked_GlycosylationVFYSEYQNISNTGLS
HHHHHHCCCCCCCCC		38.46UniProtKB CARBOHYD
274PhosphorylationYSEYQNISNTGLSTQ
HHHHCCCCCCCCCHH		35.57-
292UbiquitinationIFAELISAIKRTLAR
HHHHHHHHHHHHHHH		12.3427667366
460PhosphorylationPSANNQRYAFMPLID
CCCCCCCEEEEEEEC		8.4020639409
469PhosphorylationFMPLIDDSDDEIEEF
EEEEECCCCHHHHHH		43.1224043423
479PhosphorylationEIEEFMVTSENLTEG
HHHHHEECCCCCCCC		20.6629691806
480PhosphorylationIEEFMVTSENLTEGI
HHHHEECCCCCCCCE		17.0529691806
484PhosphorylationMVTSENLTEGIKLRA
EECCCCCCCCEEEEE		43.6929691806
492UbiquitinationEGIKLRASKSVSNGT
CCEEEEECCCCCCCC		21.0127667366
492PhosphorylationEGIKLRASKSVSNGT
CCEEEEECCCCCCCC		21.0128102081
493UbiquitinationGIKLRASKSVSNGTA
CEEEEECCCCCCCCC		54.6227667366
494PhosphorylationIKLRASKSVSNGTAK
EEEEECCCCCCCCCC		28.4323927012
496PhosphorylationLRASKSVSNGTAKPA
EEECCCCCCCCCCCC		36.3123401153
499PhosphorylationSKSVSNGTAKPATSE
CCCCCCCCCCCCCCC		35.4423927012
501UbiquitinationSVSNGTAKPATSENF
CCCCCCCCCCCCCCH		34.7233845483
504PhosphorylationNGTAKPATSENFDED
CCCCCCCCCCCHHHH		45.1323403867
505PhosphorylationGTAKPATSENFDEDL
CCCCCCCCCCHHHHH		32.4223403867
521PhosphorylationWVEENIPSSFTDVAL
HHHHHCCCCCCCCEE		34.0020639409
522PhosphorylationVEENIPSSFTDVALP
HHHHCCCCCCCCEEE		27.1520639409
524PhosphorylationENIPSSFTDVALPVL
HHCCCCCCCCEEEEE		31.3528176443
534PhosphorylationALPVLVDSDEEIMTR
EEEEEECCCHHHHCH		39.1728355574
540PhosphorylationDSDEEIMTRSEMAEK
CCCHHHHCHHHHHHH		36.3828176443
542PhosphorylationDEEIMTRSEMAEKMF
CHHHHCHHHHHHHHH		23.6622115753
547UbiquitinationTRSEMAEKMFSSEKI
CHHHHHHHHHCCCCC		35.3933845483
550PhosphorylationEMAEKMFSSEKIM--
HHHHHHHCCCCCC--		33.8024719451
553UbiquitinationEKMFSSEKIM-----
HHHHCCCCCC-----		46.1233845483
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TM87B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TM87B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TM87B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TM87B_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TM87B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, AND MASSSPECTROMETRY.

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