MRP4_HUMAN - dbPTM
MRP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRP4_HUMAN
UniProt AC O15439
Protein Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Organism Homo sapiens (Human).
Sequence Length 1325
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description May be an organic anion pump relevant to cellular detoxification..
Protein Sequence MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MLPVYQEVKPNP
---CCCCCCCCCCCC		9.3027642862
20PhosphorylationLQDANLCSRVFFWWL
CCCCCHHHHHHHHHH		34.3526552605
45PhosphorylationRLEEDDMYSVLPEDR
CCCCCCCCCCCCCCH		11.56120831
66UbiquitinationELQGFWDKEVLRAEN
HHCCCCCHHHHHHCC		40.08-
66UbiquitinationELQGFWDKEVLRAEN
HHCCCCCHHHHHHCC		40.0821906983
66 (in isoform 1)Ubiquitination-40.0821890473
66 (in isoform 2)Ubiquitination-40.0821890473
77UbiquitinationRAENDAQKPSLTRAI
HHCCCCCCCCHHHHH		37.99-
77UbiquitinationRAENDAQKPSLTRAI
HHCCCCCCCCHHHHH		37.9921906983
77 (in isoform 1)Ubiquitination-37.9921890473
77 (in isoform 2)Ubiquitination-37.9921890473
79PhosphorylationENDAQKPSLTRAIIK
CCCCCCCCHHHHHHH		49.7829449344
81PhosphorylationDAQKPSLTRAIIKCY
CCCCCCHHHHHHHHH		23.5329449344
182PhosphorylationYRKALRLSNMAMGKT
HHHHHHHCCCCCCCC		20.3746156757
189UbiquitinationSNMAMGKTTTGQIVN
CCCCCCCCCHHHHHH		24.70-
218UbiquitinationFLHFLWAGPLQAIAV
HHHHHHHCHHHHHHH		16.33-
229UbiquitinationAIAVTALLWMEIGIS
HHHHHHHHHHHHHHH		3.67-
234UbiquitinationALLWMEIGISCLAGM
HHHHHHHHHHHHHHH		7.76-
260PhosphorylationCFGKLFSSLRSKTAT
HHHHHHHHHHHCCCC		22.0723911959
264UbiquitinationLFSSLRSKTATFTDA
HHHHHHHCCCCCCHH		35.4321906983
264 (in isoform 1)Ubiquitination-35.4321890473
264 (in isoform 2)Ubiquitination-35.4321890473
269PhosphorylationRSKTATFTDARIRTM
HHCCCCCCHHHHHHH		25.1323911959
281PhosphorylationRTMNEVITGIRIIKM
HHHHHHHHHHHHHHH		31.5624719451
293UbiquitinationIKMYAWEKSFSNLIT
HHHHHHHHHHHHHHH		46.2121906983
293 (in isoform 1)Ubiquitination-46.2121890473
293 (in isoform 2)Ubiquitination-46.2121890473
304UbiquitinationNLITNLRKKEISKIL
HHHHHHCHHHHHHHH		58.9021906983
304 (in isoform 1)Ubiquitination-58.9021890473
304 (in isoform 2)Ubiquitination-58.9021890473
309UbiquitinationLRKKEISKILRSSCL
HCHHHHHHHHHHHHH		51.96-
313PhosphorylationEISKILRSSCLRGMN
HHHHHHHHHHHCCCC		23.2022817900
314PhosphorylationISKILRSSCLRGMNL
HHHHHHHHHHCCCCH		15.6722817900
388PhosphorylationVSIRRIQTFLLLDEI
HHHHHHHHHHHHHHH		17.5569301803
404PhosphorylationQRNRQLPSDGKKMVH
HHHCCCCCCCCCEEE		68.5320363803
434PhosphorylationTLQGLSFTVRPGELL
CCCCEEEEECCCCEE		16.5424719451
440UbiquitinationFTVRPGELLAVVGPV
EEECCCCEEEEECCC		4.63-
465UbiquitinationVLGELAPSHGLVSVH
HHHHHCCCCCEEEEE		25.28-
509UbiquitinationERYEKVIKACALKKD
HHHHHHHHHHHHHHH		40.16-
515UbiquitinationIKACALKKDLQLLED
HHHHHHHHHHHCCCC		65.6021906983
515 (in isoform 1)Ubiquitination-65.6021890473
515 (in isoform 2)Ubiquitination-65.6021890473
532UbiquitinationLTVIGDRGTTLSGGQ
EEEEECCCCCCCCCH		28.00-
539UbiquitinationGTTLSGGQKARVNLA
CCCCCCCHHHHHHHH		39.50-
540UbiquitinationTTLSGGQKARVNLAR
CCCCCCHHHHHHHHH		41.2421906983
540 (in isoform 1)Ubiquitination-41.2421890473
540 (in isoform 2)Ubiquitination-41.2421890473
547UbiquitinationKARVNLARAVYQDAD
HHHHHHHHHHHCCCC		27.96-
550PhosphorylationVNLARAVYQDADIYL
HHHHHHHHCCCCEEE		10.3324043423
556PhosphorylationVYQDADIYLLDDPLS
HHCCCCEEEECCCCH		11.1924043423
557UbiquitinationYQDADIYLLDDPLSA
HCCCCEEEECCCCHH		4.28-
558UbiquitinationQDADIYLLDDPLSAV
CCCCEEEECCCCHHC		3.84-
563PhosphorylationYLLDDPLSAVDAEVS
EEECCCCHHCCHHHH		31.4724043423
570PhosphorylationSAVDAEVSRHLFELC
HHCCHHHHHHHHHHH		12.8924043423
595UbiquitinationILVTHQLQYLKAASQ
HHHHHHHHHHHHHCE		34.64-
601PhosphorylationLQYLKAASQILILKD
HHHHHHHCEEEEEEC		23.7118491316
607UbiquitinationASQILILKDGKMVQK
HCEEEEEECCCEECC		58.4021906983
607 (in isoform 1)Ubiquitination-58.4021890473
607 (in isoform 2)Ubiquitination-58.4021890473
614UbiquitinationKDGKMVQKGTYTEFL
ECCCEECCCCHHHHH		41.6421906983
614 (in isoform 1)Ubiquitination-41.6421890473
614 (in isoform 2)Ubiquitination-41.6421890473
620UbiquitinationQKGTYTEFLKSGIDF
CCCCHHHHHHCCCCH		8.86-
622UbiquitinationGTYTEFLKSGIDFGS
CCHHHHHHCCCCHHH		52.5421906983
622 (in isoform 1)Ubiquitination-52.5421890473
622 (in isoform 2)Ubiquitination-52.5421890473
623PhosphorylationTYTEFLKSGIDFGSL
CHHHHHHCCCCHHHH		43.0324732914
627UbiquitinationFLKSGIDFGSLLKKD
HHHCCCCHHHHCCCC		7.2821890473
629PhosphorylationKSGIDFGSLLKKDNE
HCCCCHHHHCCCCCC		30.4424732914
632UbiquitinationIDFGSLLKKDNEESE
CCHHHHCCCCCCCCC		64.4721906983
632 (in isoform 1)Ubiquitination-64.4721890473
632 (in isoform 2)Ubiquitination-64.4721890473
633UbiquitinationDFGSLLKKDNEESEQ
CHHHHCCCCCCCCCC		66.8021906983
633 (in isoform 1)Ubiquitination-66.8021890473
633 (in isoform 2)Ubiquitination-66.8021890473
638PhosphorylationLKKDNEESEQPPVPG
CCCCCCCCCCCCCCC		35.0423927012
646PhosphorylationEQPPVPGTPTLRNRT
CCCCCCCCCCCCCCC		13.6619664994
648PhosphorylationPPVPGTPTLRNRTFS
CCCCCCCCCCCCCCC		37.8829255136
651N-linked_GlycosylationPGTPTLRNRTFSESS
CCCCCCCCCCCCHHH		50.92UniProtKB CARBOHYD
653PhosphorylationTPTLRNRTFSESSVW
CCCCCCCCCCHHHHC		34.7530266825
655PhosphorylationTLRNRTFSESSVWSQ
CCCCCCCCHHHHCCC		35.6423401153
657PhosphorylationRNRTFSESSVWSQQS
CCCCCCHHHHCCCCC		29.0630266825
658PhosphorylationNRTFSESSVWSQQSS
CCCCCHHHHCCCCCC		24.4530266825
661PhosphorylationFSESSVWSQQSSRPS
CCHHHHCCCCCCCCC		19.0423401153
664PhosphorylationSSVWSQQSSRPSLKD
HHHCCCCCCCCCCCC		22.2225159151
665PhosphorylationSVWSQQSSRPSLKDG
HHCCCCCCCCCCCCC		43.8225159151
668PhosphorylationSQQSSRPSLKDGALE
CCCCCCCCCCCCCCC		47.1125159151
670UbiquitinationQSSRPSLKDGALESQ
CCCCCCCCCCCCCCC		59.4621906983
670 (in isoform 1)Ubiquitination-59.4621890473
676PhosphorylationLKDGALESQDTENVP
CCCCCCCCCCCCCCC		33.9227422710
679PhosphorylationGALESQDTENVPVTL
CCCCCCCCCCCCCCC		23.0927422710
685PhosphorylationDTENVPVTLSEENRS
CCCCCCCCCCCCCCC		20.6330108239
687PhosphorylationENVPVTLSEENRSEG
CCCCCCCCCCCCCCC		33.2325627689
690N-linked_GlycosylationPVTLSEENRSEGKVG
CCCCCCCCCCCCCCC		49.04UniProtKB CARBOHYD
692PhosphorylationTLSEENRSEGKVGFQ
CCCCCCCCCCCCCHH		63.3825627689
695UbiquitinationEENRSEGKVGFQAYK
CCCCCCCCCCHHHHH		34.8221906983
695 (in isoform 1)Ubiquitination-34.8221890473
702UbiquitinationKVGFQAYKNYFRAGA
CCCHHHHHHHHHHHH		48.4621890473
702 (in isoform 1)Ubiquitination-48.4621890473
702UbiquitinationKVGFQAYKNYFRAGA
CCCHHHHHHHHHHHH		48.4621890473
732UbiquitinationQVAYVLQDWWLSYWA
HHHHHHHHHHHHHHC		34.07-
746N-linked_GlycosylationANKQSMLNVTVNGGG
CCCCCCEEEEECCCC		20.8326721430
754N-linked_GlycosylationVTVNGGGNVTEKLDL
EEECCCCCCCEECCC		40.5926721430
792N-linked_GlycosylationLVFYVLVNSSQTLHN
HHHHHHHCCCHHHHH		31.61UniProtKB CARBOHYD
804PhosphorylationLHNKMFESILKAPVL
HHHHHHHHHHCCCEE		23.1924719451
807AcetylationKMFESILKAPVLFFD
HHHHHHHCCCEEEEC		49.3130586669
807UbiquitinationKMFESILKAPVLFFD
HHHHHHHCCCEEEEC		49.31-
913PhosphorylationSSLQGLWTIRAYKAE
HHCCHHHHHHHHHHH		12.9646156763
918UbiquitinationLWTIRAYKAEERCQE
HHHHHHHHHHHHHHH		48.62-
974 (in isoform 2)Ubiquitination-4.1321890473
1016PhosphorylationSVERVIEYTDLEKEA
EEEEEEECCCCHHCC		8.40110736365
1021UbiquitinationIEYTDLEKEAPWEYQ
EECCCCHHCCCCCCC		67.4821906983
1021 (in isoform 1)Ubiquitination-67.4821890473
1023 (in isoform 2)Ubiquitination-26.1021890473
1066UbiquitinationKHLTALIKSQEKVGI
HHHHHHHHCCCCCCE		47.11-
1070UbiquitinationALIKSQEKVGIVGRT
HHHHCCCCCCEECCC		37.8221906983
1070 (in isoform 1)Ubiquitination-37.8221890473
1097UbiquitinationRLSEPEGKIWIDKIL
HHCCCCCCEEEEHHH		32.95-
1118 (in isoform 2)Ubiquitination-26.6721890473
1130PhosphorylationEPVLFTGTMRKNLDP
CCEEEECCCCCCCCC		15.67113300635
1133UbiquitinationLFTGTMRKNLDPFNE
EEECCCCCCCCCCCC		51.55-
1165UbiquitinationTIEDLPGKMDTELAE
HHHHCCCCCCHHHHH		31.5021906983
1165 (in isoform 1)Ubiquitination-31.5021890473
1176N-linked_GlycosylationELAESGSNFSVGQRQ
HHHHCCCCCCHHHHH		36.42UniProtKB CARBOHYD
1206 (in isoform 2)Ubiquitination-34.0821890473
1217UbiquitinationRTDELIQKKIREKFA
CCHHHHHHHHHHHHC		43.08-
1218 (in isoform 2)Ubiquitination-30.5321890473
1224 (in isoform 2)Ubiquitination-14.1221890473
1227PhosphorylationREKFAHCTVLTIAHR
HHHHCHHHHHHHHHH		14.5326074081
1230PhosphorylationFAHCTVLTIAHRLNT
HCHHHHHHHHHHHCH		16.2826074081
1231 (in isoform 2)Ubiquitination-2.3821890473
1237PhosphorylationTIAHRLNTIIDSDKI
HHHHHHCHHCCCCCE		24.7326074081
1241PhosphorylationRLNTIIDSDKIMVLD
HHCHHCCCCCEEEEE		30.3226074081
1242 (in isoform 2)Ubiquitination-40.5321890473
1253UbiquitinationVLDSGRLKEYDEPYV
EEECCCCCCCCCCEE		53.5221906983
1253 (in isoform 1)Ubiquitination-53.5221890473
1255PhosphorylationDSGRLKEYDEPYVLL
ECCCCCCCCCCEEEE		24.8275061
1259PhosphorylationLKEYDEPYVLLQNKE
CCCCCCCEEEECCHH		11.1522817900
1265UbiquitinationPYVLLQNKESLFYKM
CEEEECCHHHHHHHH		35.4021890473
1265 (in isoform 1)Ubiquitination-35.4021890473
1271UbiquitinationNKESLFYKMVQQLGK
CHHHHHHHHHHHHCH		25.8421890473
1271 (in isoform 1)Ubiquitination-25.8421890473
1278UbiquitinationKMVQQLGKAEAAALT
HHHHHHCHHHHHHHH		52.2021906983
1278 (in isoform 1)Ubiquitination-52.2021890473
1289UbiquitinationAALTETAKQVYFKRN
HHHHHHHHHHHHHCC		47.9521890473
1289 (in isoform 1)Ubiquitination-47.9521890473
1309N-linked_GlycosylationHTDHMVTNTSNGQPS
CCCCEEEECCCCCEE		30.05UniProtKB CARBOHYD
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNX27_HUMANSNX27physical
22411990
NHRF1_HUMANSLC9A3R1physical
18559527
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00142 Methotrexate (JP16/USP/INN); Mexate (TN)
D00331 Furosemide (JP16/USP/INN); Frusemide; Lasix (TN)
D00567 Celecoxib (JAN/USAN/INN); Celebrex (TN)
D00903 Diclofenac potassium (USAN); Cambia (TN); Cataflam (TN); Zipsor (TN)
D00904 Diclofenac sodium (JP16/USP); Solaraze (TN); Voltaren (TN)
D01655 Adefovir pivoxil (JAN); Adefovir dipivoxil (USAN); Hepsera (TN)
D02115 Methotrexate sodium; Trexall (TN)
D02168 Nogitecan hydrochloride (JAN); Topotecan hydrochloride (USAN); Hycamtin (TN)
D02768 Adefovir (USAN/INN)
D06074 Tenofovir (USAN); Tenofovir hydrate
D07816 Diclofenac (INN); Solaraze (TN)
D07817 Diclofenac diethylamine; Voltaren Emulgel (TN)
D07818 Diclofenac hydroxyethylpyrrolidine; Flector (TN)
D07819 Diclofenac calcium; Voltaren Actingo Extra (TN)
D07999 Sodium furosemide; Frosemide sodium; Lasix (TN)
D08001 Furosemide diolamine; Furosemide diethanolamine salt; Nuriban (TN)
D08618 Topotecan (BAN); Hycamtin (TN)
DrugBank
DB00718Adefovir Dipivoxil
DB00770Alprostadil
DB01076Atorvastatin
DB01327Cefazolin
DB00482Celecoxib
DB02659Cholic Acid
DB00286Conjugated Estrogens
DB00586Diclofenac
DB00917Dinoprostone
DB00975Dipyridamole
DB00544Fluorouracil
DB00712Flurbiprofen
DB00158Folic Acid
DB08884Gadoxetate
DB00143Glutathione
DB01050Ibuprofen
DB00328Indomethacin
DB01009Ketoprofen
DB00709Lamivudine
DB00650Leucovorin
DB00814Meloxicam
DB01033Mercaptopurine
DB00563Methotrexate
DB00731Nateglinide
DB00198Oseltamivir
DB01032Probenecid
DB01098Rosuvastatin
DB00203Sildenafil
DB00398Sorafenib
DB01138Sulfinpyrazone
DB01268Sunitinib
DB00300Tenofovir
DB00352Tioguanine
DB01586Ursodeoxycholic acid
DB00661Verapamil
DB00495Zidovudine
Regulatory Network of MRP4_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-646, AND MASSSPECTROMETRY.

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