CLCN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLCN3_HUMAN
• UniProt AC: P51790
• Protein Name: H(+)/Cl(-) exchange transporter 3
• Gene Name: CLCN3
• Organism: Homo sapiens (Human).
• Sequence Length: 818
• Subcellular Localization: Isoform 1: Early endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Isoform 1 is localized mainly in late endosomes.
• Protein Description: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory..
• Protein Sequence: MESEQLFHRGYYRNSYNSITSASSDEELLDGAGVIMDFQTSEDDNLLDGDTAVGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTANQDPASIMFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	DNLLDGDTAVGTHYT CCCCCCCCEEECEEE	28.86	14754994
109	Phosphorylation	ERHRRINSKKKESAW HHHHHHHHHHHHHHH	43.40	26657352
114	Phosphorylation	INSKKKESAWEMTKS HHHHHHHHHHHHHHH	47.78	29514088
119	Phosphorylation	KESAWEMTKSLYDAW HHHHHHHHHHHHHHC	13.13	29514088
177	N-linked_Glycosylation	EQCCWGSNETTFEER CCCCCCCCCCCHHHH	46.85	UniProtKB CARBOHYD
246	Phosphorylation	SGIPEIKTILSGFII CCCHHHHHHHHHHHH	32.58	22210691
256	Phosphorylation	SGFIIRGYLGKWTLM HHHHHHHHCCHHHHH	11.48	22210691
261	Phosphorylation	RGYLGKWTLMIKTIT HHHCCHHHHHHHHHH	15.21	22210691
275	Phosphorylation	TLVLAVASGLSLGKE HHHHHHHHCCCCCCC	33.40	22210691
297	Phosphorylation	CCCGNIFSYLFPKYS ECCCHHHHHHCCCCC	19.68	-
372	Phosphorylation	SINPFGNSRLVLFYV HCCCCCCEEEEEEEE	27.63	-
440	Ubiquitination	IVAAITAVIAFPNPY HHHHHHHHHHCCCCC	2.13	-
451	N-linked_Glycosylation	PNPYTRLNTSELIKE CCCCCCCCHHHHHHH	37.96	UniProtKB CARBOHYD
457 (in isoform 2)	Ubiquitination	-	62.07	-
479	N-linked_Glycosylation	CDYRNDMNASKIVDD CCCCCCCCHHHHCCC	43.88	UniProtKB CARBOHYD
601	Phosphorylation	VVIVFELTGGLEYIV EEEEEECCCCHHHHH	23.23	26074081
606	Phosphorylation	ELTGGLEYIVPLMAA ECCCCHHHHHHHHHH	16.56	26074081
616	Phosphorylation	PLMAAVMTSKWVGDA HHHHHHHCCCCCHHH	22.13	26074081
617	Phosphorylation	LMAAVMTSKWVGDAF HHHHHHCCCCCHHHH	13.36	26074081
645	Ubiquitination	GYPFLDAKEEFTHTT CCCCCCCCHHCCCCC	58.40	-
681	Ubiquitination	NMTVDDIENMINETS CCCHHHHHHHHHHCC	47.98	-
698 (in isoform 2)	Ubiquitination	-	43.96	-
713	Phosphorylation	FALRRDLTIAIESAR HHHHCHHHHHHHHHH	16.80	-
718	Phosphorylation	DLTIAIESARKKQEG HHHHHHHHHHHHCCC	27.53	-
738	Phosphorylation	RVCFAQHTPSLPAES CEEEECCCCCCCCCC	11.51	25159151
740	Phosphorylation	CFAQHTPSLPAESPR EEECCCCCCCCCCCC	48.41	26074081
745	Phosphorylation	TPSLPAESPRPLKLR CCCCCCCCCCCCCHH	28.45	30576142
750	Malonylation	AESPRPLKLRSILDM CCCCCCCCHHHHHCC	44.53	26320211
750	Acetylation	AESPRPLKLRSILDM CCCCCCCCHHHHHCC	44.53	25953088
798	Ubiquitination	LLGIITKKDILRHMA EEEEEEHHHHHHHHH	41.15	-
847 (in isoform 2)	Phosphorylation	-		19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
51	S	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM
109	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLCN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLCN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCN3_HUMAN	CLCN3	physical	12471024

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.