RNF12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF12_HUMAN
• UniProt AC: Q9NVW2
• Protein Name: E3 ubiquitin-protein ligase RLIM
• Gene Name: RLIM
• Organism: Homo sapiens (Human).
• Sequence Length: 624
• Subcellular Localization: Nucleus .
• Protein Description: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals..
• Protein Sequence: MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRESVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENSDSND -------CCCCCCCC	11.25	22814378
4	Phosphorylation	----MENSDSNDKGS ----CCCCCCCCCCC	29.16	28450419
6	Phosphorylation	--MENSDSNDKGSGD --CCCCCCCCCCCCC	46.91	28450419
9	Ubiquitination	ENSDSNDKGSGDQSA CCCCCCCCCCCCHHH	60.26	33845483
21	Phosphorylation	QSAAQRRSQMDRLDR HHHHHHHHHHHHHHH	31.85	-
33	Phosphorylation	LDREEAFYQFVNNLS HHHHHHHHHHHHCCC	14.21	29523821
40	Phosphorylation	YQFVNNLSEEDYRLM HHHHHCCCHHHHHHH	40.85	29523821
44	Phosphorylation	NNLSEEDYRLMRDNN HCCCHHHHHHHHHCC	14.66	29523821
72	Ubiquitination	LRRLQQIKEGPPPQN HHHHHHHHCCCCCCC	52.89	21906983
117	Methylation	NTTRSGQRGNQSWRA CCCCCCCCCCCCEEE	49.94	115491373
132	Phosphorylation	VSRTNPNSGDFRFSL EECCCCCCCCEEEEE	40.78	-
163	Phosphorylation	NEPSARRSSGENVEN CCCCHHHCCCCCCCC	36.82	28985074
164	Phosphorylation	EPSARRSSGENVENN CCCHHHCCCCCCCCC	48.60	30576142
172	Phosphorylation	GENVENNSQRQVENP CCCCCCCCCCCCCCC	38.02	28102081
181	Phosphorylation	RQVENPRSESTSARP CCCCCCCCCCCCCCC	36.84	22817900
183	Phosphorylation	VENPRSESTSARPSR CCCCCCCCCCCCCCC	28.98	29523821
184	Phosphorylation	ENPRSESTSARPSRS CCCCCCCCCCCCCCC	23.50	29523821
185	Phosphorylation	NPRSESTSARPSRSE CCCCCCCCCCCCCCC	31.40	22817900
189	Phosphorylation	ESTSARPSRSERNST CCCCCCCCCCCCCCC	42.77	29523821
191	Phosphorylation	TSARPSRSERNSTEA CCCCCCCCCCCCCHH	45.29	28450419
195	Phosphorylation	PSRSERNSTEALTEV CCCCCCCCCHHHHCC	33.57	28450419
196	Phosphorylation	SRSERNSTEALTEVP CCCCCCCCHHHHCCC	28.91	28450419
200	Phosphorylation	RNSTEALTEVPPTRG CCCCHHHHCCCCCCC	41.82	28450419
213	Phosphorylation	RGQRRARSRSPDHRR CCCCCHHHCCCCHHH	35.80	30576142
215	Phosphorylation	QRRARSRSPDHRRTR CCCHHHCCCCHHHHH	35.61	30576142
228	Phosphorylation	TRARAERSRSPLHPM HHHHHHHHCCCCCCC	28.72	23927012
230	Phosphorylation	ARAERSRSPLHPMSE HHHHHHCCCCCCCCC	32.81	23927012
236	Phosphorylation	RSPLHPMSEIPRRSH CCCCCCCCCCCCCCC	36.50	23927012
276	Phosphorylation	VTLRQQISGPELLSR EEHHHHCCCHHHHHC	43.91	25787250
282	Phosphorylation	ISGPELLSRGLFAAS CCCHHHHHCCEEEEC	36.61	23312004
295	Phosphorylation	ASGTRNASQGAGSSD ECCCCCCCCCCCCCC	32.47	-
347	Phosphorylation	ASRTRSRSQTPNNTV HHCCCCCCCCCCCEE	39.39	-
349	Phosphorylation	RTRSRSQTPNNTVTY CCCCCCCCCCCEEEE	29.27	28985074
360	Methylation	TVTYESERGGFRRTF EEEEEECCCCEEEEE	60.87	26494409
364	Methylation	ESERGGFRRTFSRSE EECCCCEEEEECHHH	39.75	30989225
459	Phosphorylation	GSSSGSSSSSSSSSS CCCCCCCCCCCCCCC	35.62	-
460	Phosphorylation	SSSGSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
461	Phosphorylation	SSGSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
462	Phosphorylation	SGSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
463	Phosphorylation	GSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
464	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
465	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
466	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
467	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
468	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
469	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
470	Phosphorylation	SSSSSSSSSSSSSSP CCCCCCCCCCCCCCC	35.87	-
471	Phosphorylation	SSSSSSSSSSSSSPS CCCCCCCCCCCCCCC	35.87	-
472	Phosphorylation	SSSSSSSSSSSSPSS CCCCCCCCCCCCCCC	35.87	24275569
503	Phosphorylation	SNEGSSSSGSSGARR CCCCCCCCCCCCCCC	44.64	-
505	Phosphorylation	EGSSSSGSSGARREG CCCCCCCCCCCCCCC	27.78	-
506	Phosphorylation	GSSSSGSSGARREGR CCCCCCCCCCCCCCC	39.74	-
550	Ubiquitination	DQPRGLTKEQIDNLA CCCCCCCHHHHHHHH	53.30	21963094
558	Sulfoxidation	EQIDNLAMRSFGEND HHHHHHHHHHHCCCC	4.09	21406390
568	Ubiquitination	FGENDALKTCSVCIT HCCCCHHHHCCEEEE	49.56	29967540
582	Ubiquitination	TEYTEGNKLRKLPCS EECCCCCCEEECCCC	61.60	22505724
585	Ubiquitination	TEGNKLRKLPCSHEY CCCCCEEECCCCCEE	68.19	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:31801865

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF12_HUMAN	RLIM	physical	19117995
ESR1_HUMAN	ESR1	physical	19117995
PDLI1_HUMAN	PDLIM1	physical	19117995
LDB1_HUMAN	LDB1	physical	20423330
REXO1_HUMAN	REXO1	physical	22596162
SMUF2_HUMAN	SMURF2	physical	21945933
TERF1_HUMAN	TERF1	physical	19164295
UB2D1_HUMAN	UBE2D1	physical	22596162
UB2D1_HUMAN	UBE2D1	physical	19164295
LNX2_HUMAN	LNX2	physical	22493164
RS14_HUMAN	RPS14	physical	21988832
SNX17_HUMAN	SNX17	physical	21988832
STMN1_HUMAN	STMN1	physical	24686088
STMN1_HUMAN	STMN1	physical	26317901
MDM2_HUMAN	MDM2	physical	26926424
UB2D1_HUMAN	UBE2D1	physical	26926424
REN3B_HUMAN	UPF3B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.