LNX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LNX2_HUMAN
• UniProt AC: Q8N448
• Protein Name: Ligand of Numb protein X 2
• Gene Name: LNX2
• Organism: Homo sapiens (Human).
• Sequence Length: 690
• Protein Sequence: MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTTSDEMVS -----CCCCHHHCEE	23.10	22468782
4	Phosphorylation	----MGTTSDEMVSV ----CCCCHHHCEEC	28.57	22468782
5	Phosphorylation	---MGTTSDEMVSVE ---CCCCHHHCEECE	31.26	22468782
289	Phosphorylation	QILQVNNYNISNVSH EEEEECCEECCCCCH	14.52	30242111
292	Phosphorylation	QVNNYNISNVSHNYA EECCEECCCCCHHHH	27.78	30242111
295	Phosphorylation	NYNISNVSHNYARAV CEECCCCCHHHHHHH	15.40	30242111
298	Phosphorylation	ISNVSHNYARAVLSQ CCCCCHHHHHHHHCC	7.64	30242111
300	Ubiquitination	NVSHNYARAVLSQPC CCCHHHHHHHHCCCC	18.18	23000965
332	Phosphorylation	HNHSDSNSPREEIFQ CCCCCCCCCHHHHHH	29.32	18669648
354	Ubiquitination	SGEQLGIKLVRRTDE CCCCCEEEEEECCCC	38.85	29967540
359	Phosphorylation	GIKLVRRTDEPGVFI EEEEEECCCCCCEEE	33.86	-
397	Phosphorylation	INGHDLKYGTPELAA ECCCCCCCCCHHHHH	33.26	-
399	Phosphorylation	GHDLKYGTPELAAQI CCCCCCCCHHHHHHH	15.53	-
423	Ubiquitination	LTIARPGKPQPGNTI EEEECCCCCCCCCCC	43.07	23000965
429	Phosphorylation	GKPQPGNTIREAGNH CCCCCCCCCCCCCCC	27.59	23312004
453	Phosphorylation	PPYYSRPSSHKDLTQ CCCCCCCCCCCCHHH	43.92	23312004
454	Phosphorylation	PYYSRPSSHKDLTQC CCCCCCCCCCCHHHC	36.92	23312004
456	Ubiquitination	YSRPSSHKDLTQCVT CCCCCCCCCHHHCEE	57.28	29967540
459	Phosphorylation	PSSHKDLTQCVTCQE CCCCCCHHHCEECCC	30.01	23312004
463	Phosphorylation	KDLTQCVTCQEKHIT CCHHHCEECCCCEEE	18.98	23312004
473	Ubiquitination	EKHITVKKEPHESLG CCEEEECCCCCCCCC	72.62	-
540	Ubiquitination	SEAVAMLKASAASPA HHHHHHHHHHCCCHH	27.49	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LNX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LNX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LNX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD8A_HUMAN	CD8A	physical	22045731
KPCA_HUMAN	PRKCA	physical	22087225
PKHG5_HUMAN	PLEKHG5	physical	22087225
CXAR_HUMAN	CXADR	physical	22889411
PKDRE_HUMAN	PKDREJ	physical	22889411
PZRN3_HUMAN	PDZRN3	physical	22889411
PZRN4_HUMAN	PDZRN4	physical	22889411
MDGA1_HUMAN	MDGA1	physical	22889411
CBX4_HUMAN	CBX4	physical	22889411
SHSA2_HUMAN	SHISA2	physical	22889411
LNX2_HUMAN	LNX2	physical	25416956
PEG10_HUMAN	PEG10	physical	21516116
MSRB3_HUMAN	MSRB3	physical	21516116
MYLIP_HUMAN	MYLIP	physical	21516116
IL16_HUMAN	IL16	physical	21516116
ATPB_HUMAN	ATP5B	physical	21516116
NMD3_HUMAN	NMD3	physical	21516116
IP6K2_HUMAN	IP6K2	physical	21516116
SCLY_HUMAN	SCLY	physical	21516116
PTCD3_HUMAN	PTCD3	physical	21516116
MK09_HUMAN	MAPK9	physical	21516116
MP2K5_HUMAN	MAP2K5	physical	21516116
TRAF2_HUMAN	TRAF2	physical	21516116
VTNC_HUMAN	VTN	physical	21516116
DDA1_HUMAN	DDA1	physical	21516116
CJ088_HUMAN	C10orf88	physical	21516116
LRC8E_HUMAN	LRRC8E	physical	21516116
SPF45_HUMAN	RBM17	physical	21516116
AT2L2_HUMAN	PHYKPL	physical	21516116
P55G_HUMAN	PIK3R3	physical	21516116
SRS11_HUMAN	SRSF11	physical	21516116
LNX2_HUMAN	LNX2	physical	26451611
UB2D2_HUMAN	UBE2D2	physical	26451611
NUMB_HUMAN	NUMB	physical	26451611
EPHA7_HUMAN	EPHA7	physical	29121065
SYGP1_HUMAN	SYNGAP1	physical	29121065
KLH11_HUMAN	KLHL11	physical	29121065

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.