IL16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL16_HUMAN
• UniProt AC: Q14005
• Protein Name: Pro-interleukin-16
• Gene Name: IL16
• Organism: Homo sapiens (Human).
• Sequence Length: 1332
• Subcellular Localization: Interleukin-16: Secreted.; Isoform 1: Cytoplasm.; Isoform 3: Cytoplasm. Nucleus.
• Protein Description: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells..
• Protein Sequence: MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSSVQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	LMLCNAKTSDDGSSP HHHCCCCCCCCCCCC	34.67	23312004
31	Phosphorylation	MLCNAKTSDDGSSPD HHCCCCCCCCCCCCC	32.76	23312004
35	Phosphorylation	AKTSDDGSSPDEKYP CCCCCCCCCCCCCCC	45.77	29209046
36	Phosphorylation	KTSDDGSSPDEKYPD CCCCCCCCCCCCCCC	41.73	29209046
41	Phosphorylation	GSSPDEKYPDPFEIS CCCCCCCCCCCEEEE	15.72	23312004
48	Phosphorylation	YPDPFEISLAQGKEG CCCCEEEEECCCCCC	15.51	23312004
108	Phosphorylation	FFMKESSTASSREKP EEEECCCCCCCCCCC	39.58	26074081
110	Phosphorylation	MKESSTASSREKPGK EECCCCCCCCCCCCC	29.98	26074081
111	Phosphorylation	KESSTASSREKPGKL ECCCCCCCCCCCCCC	41.83	26074081
137	Phosphorylation	ACHQRARSNSTSVNP HHHHHHHHCCCCCCH	33.86	27251275
139	Phosphorylation	HQRARSNSTSVNPYC HHHHHHCCCCCCHHC	24.25	27251275
140	Phosphorylation	QRARSNSTSVNPYCT HHHHHCCCCCCHHCC	40.73	27251275
141	Phosphorylation	RARSNSTSVNPYCTR HHHHCCCCCCHHCCC	21.51	22210691
144	Phosphorylation	SNSTSVNPYCTREID HCCCCCCHHCCCCCC	24.34	14768064
145	Phosphorylation	NSTSVNPYCTREIDF CCCCCCHHCCCCCCC	10.97	22210691
155	Phosphorylation	REIDFPMTKKSAAPT CCCCCCCCCCCCCCC	35.24	29759185
175	Phosphorylation	SLCSNRKSLSQQLDC CCCCCCHHHHHHCCC	29.98	25850435
177	Phosphorylation	CSNRKSLSQQLDCPA CCCCHHHHHHCCCCC	23.99	25850435
196	Phosphorylation	GTSRPTRSLSTAQLV CCCCCCCCCCHHEEE	29.20	27251275
198	Phosphorylation	SRPTRSLSTAQLVQP CCCCCCCCHHEEECC	23.96	27251275
199	Phosphorylation	RPTRSLSTAQLVQPS CCCCCCCHHEEECCC	24.58	27251275
298	Phosphorylation	KKGLLTLTVRTRLTA HCCCEEEEEECCCCC	11.60	24670416
301	Phosphorylation	LLTLTVRTRLTAPPS CEEEEEECCCCCCHH	26.20	24670416
304	Phosphorylation	LTVRTRLTAPPSLCS EEEECCCCCCHHHHH	33.55	23312004
308	Phosphorylation	TRLTAPPSLCSHLSP CCCCCCHHHHHCCCH	40.73	23312004
311	Phosphorylation	TAPPSLCSHLSPPLC CCCHHHHHCCCHHHH	32.53	23312004
314	Phosphorylation	PSLCSHLSPPLCRSL HHHHHCCCHHHHHHC	21.03	23312004
320	Phosphorylation	LSPPLCRSLSSSTCI CCHHHHHHCCCCEEE	31.44	23312004
322	Phosphorylation	PPLCRSLSSSTCITK HHHHHHCCCCEEEEC	24.40	23911959
323	Phosphorylation	PLCRSLSSSTCITKD HHHHHCCCCEEEECC	34.65	23312004
325	Phosphorylation	CRSLSSSTCITKDSS HHHCCCCEEEECCCC	15.18	23911959
331	Phosphorylation	STCITKDSSSFALES CEEEECCCCCCCCCC	29.45	-
471	Phosphorylation	GKERHQWSLEGVKRL CHHHHCCCHHHHHHH	15.24	24719451
480	Phosphorylation	EGVKRLESSWHGRPT HHHHHHHHHCCCCCC	43.23	27251275
481	Phosphorylation	GVKRLESSWHGRPTL HHHHHHHHCCCCCCH	17.45	27251275
510	Phosphorylation	AQKVMIRSSSDSSYM HCEEEEECCCCCCCC	24.22	27251275
511	Phosphorylation	QKVMIRSSSDSSYMS CEEEEECCCCCCCCC	28.46	27251275
512	Phosphorylation	KVMIRSSSDSSYMSG EEEEECCCCCCCCCC	42.64	27251275
514	Phosphorylation	MIRSSSDSSYMSGSP EEECCCCCCCCCCCC	25.89	29507054
515	Phosphorylation	IRSSSDSSYMSGSPG EECCCCCCCCCCCCC	29.82	27251275
543	Phosphorylation	DVDISTHSPSLPLAR CCCCCCCCCCCCCCC	19.10	29507054
566	Phosphorylation	SSRLPQESPPLPESR CCCCCCCCCCCCCCC	26.94	29255136
572	Phosphorylation	ESPPLPESRDSHPPL CCCCCCCCCCCCCCC	39.17	-
584	Phosphorylation	PPLRLKKSFEILVRK CCCCCCCEEEEEECC	26.90	23911959
594	Phosphorylation	ILVRKPMSSKPKPPP EEECCCCCCCCCCCC	43.68	24719451
614	Phosphorylation	SDSDPQKSLEERENS CCCCHHHCHHHHHHC	35.45	24719451
631	Phosphorylation	SSGHTPPTCGQEARE CCCCCCCCCCHHHHH	30.39	-
683	Phosphorylation	EPGWRRASPVTQTSP CCCCCCCCCCCCCCC	20.35	22985185
689	Phosphorylation	ASPVTQTSPIKHPLL CCCCCCCCCCCCHHH	18.14	24719451
705	Phosphorylation	RQARMDYSFDTTAED CCCCCCCCCCCCCCC	16.63	27251275
743	Phosphorylation	MPLQPNASLNEEEGT CCCCCCCCCCCCCCC	38.07	12450396
757	Phosphorylation	TQGHPDGTPPKLDTA CCCCCCCCCCCCCCC	43.74	12450396
771	Phosphorylation	ANGTPKVYKSADSST CCCCCCEEECCCCCC	12.83	-
772	Ubiquitination	NGTPKVYKSADSSTV CCCCCEEECCCCCCC	42.00	-
788	Ubiquitination	KGPPVAPKPAWFRQS CCCCCCCCCHHHHHH	37.32	-
795	Phosphorylation	KPAWFRQSLKGLRNR CCHHHHHHHHHHHHH	28.00	23401153
804	Phosphorylation	KGLRNRASDPRGLPD HHHHHHCCCCCCCCC	44.93	27251275
828	Phosphorylation	ASREHLGSHIRASSS CCHHHHHHHCCCCCC	23.31	23401153
833	Phosphorylation	LGSHIRASSSSSSIR HHHHCCCCCCCHHHH	22.39	25072903
834	Phosphorylation	GSHIRASSSSSSIRQ HHHCCCCCCCHHHHH	33.00	28857561
835	Phosphorylation	SHIRASSSSSSIRQR HHCCCCCCCHHHHHH	31.57	28857561
836	Phosphorylation	HIRASSSSSSIRQRI HCCCCCCCHHHHHHH	30.01	25072903
837	Phosphorylation	IRASSSSSSIRQRIS CCCCCCCHHHHHHHH	31.56	25072903
838	Phosphorylation	RASSSSSSIRQRISS CCCCCCHHHHHHHHH	24.60	25072903
844	Phosphorylation	SSIRQRISSFETFGS HHHHHHHHHCCCCCC	31.03	23401153
845	Phosphorylation	SIRQRISSFETFGSS HHHHHHHHCCCCCCC	25.40	23401153
848	Phosphorylation	QRISSFETFGSSQLP HHHHHCCCCCCCCCC	31.14	30108239
851	Phosphorylation	SSFETFGSSQLPDKG HHCCCCCCCCCCCCC	15.66	29978859
852	Phosphorylation	SFETFGSSQLPDKGA HCCCCCCCCCCCCCC	35.79	29978859
857	Ubiquitination	GSSQLPDKGAQRLSL CCCCCCCCCCCCCEE	54.96	-
863	Phosphorylation	DKGAQRLSLQPSSGE CCCCCCCEECCCCCC	27.44	26657352
867	Phosphorylation	QRLSLQPSSGEAAKP CCCEECCCCCCCCCC	37.71	23312004
868	Phosphorylation	RLSLQPSSGEAAKPL CCEECCCCCCCCCCC	47.54	28857561
882	Methylation	LGKHEEGRFSGLLGR CCCCCCCCCCCCCCC	26.32	115386449
884	Phosphorylation	KHEEGRFSGLLGRGA CCCCCCCCCCCCCCC	27.46	27251275
889	Methylation	RFSGLLGRGAAPTLV CCCCCCCCCCCCCCC	31.39	115386457
894	Phosphorylation	LGRGAAPTLVPQQPE CCCCCCCCCCCCCHH	35.34	29978859
905	Phosphorylation	QQPEQVLSSGSPAAS CCHHHHHHCCCCCHH	33.52	30108239
906	Phosphorylation	QPEQVLSSGSPAASE CHHHHHHCCCCCHHH	38.85	30108239
908	Phosphorylation	EQVLSSGSPAASEAR HHHHHCCCCCHHHCC	17.20	30108239
912	Phosphorylation	SSGSPAASEARDPGV HCCCCCHHHCCCCCC	33.62	30108239
920	Phosphorylation	EARDPGVSESPPPGR HCCCCCCCCCCCCCC	37.97	23401153
922	Phosphorylation	RDPGVSESPPPGRQP CCCCCCCCCCCCCCC	34.89	23401153
933	Phosphorylation	GRQPNQKTLPPGPDP CCCCCCCCCCCCCCH	34.43	-
946	Phosphorylation	DPLLRLLSTQAEESQ CHHHHHHHHCCHHHC	24.06	23401153
947	Phosphorylation	PLLRLLSTQAEESQG HHHHHHHHCCHHHCC	31.59	28450419
952	Phosphorylation	LSTQAEESQGPVLKM HHHCCHHHCCCCCCC	31.76	23684312
961	Phosphorylation	GPVLKMPSQRARSFP CCCCCCCCHHHHCCC	28.88	26074081
966	Phosphorylation	MPSQRARSFPLTRSQ CCCHHHHCCCCCCCC	30.17	23401153
970	Phosphorylation	RARSFPLTRSQSCET HHHCCCCCCCCCCCE	28.63	26074081
972	Phosphorylation	RSFPLTRSQSCETKL HCCCCCCCCCCCEEE	22.62	26657352
974	Phosphorylation	FPLTRSQSCETKLLD CCCCCCCCCCEEECC	18.37	26261332
977	Phosphorylation	TRSQSCETKLLDEKT CCCCCCCEEECCHHH	31.18	27486199
978	Trimethylation	RSQSCETKLLDEKTS CCCCCCEEECCHHHH	25.43	-
978	Methylation	RSQSCETKLLDEKTS CCCCCCEEECCHHHH	25.43	-
984	Phosphorylation	TKLLDEKTSKLYSIS EEECCHHHHHHHCHH	29.10	21949786
985	Phosphorylation	KLLDEKTSKLYSISS EECCHHHHHHHCHHH	31.56	21949786
988	Phosphorylation	DEKTSKLYSISSQVS CHHHHHHHCHHHHHH	14.01	29978859
989	Phosphorylation	EKTSKLYSISSQVSS HHHHHHHCHHHHHHH	26.82	29978859
995	Phosphorylation	YSISSQVSSAVMKSL HCHHHHHHHHHHHHH	12.63	-
996	Phosphorylation	SISSQVSSAVMKSLL CHHHHHHHHHHHHHH	26.48	-
1001	O-linked_Glycosylation	VSSAVMKSLLCLPSS HHHHHHHHHHHCCCC	14.42	27655845
1001	Phosphorylation	VSSAVMKSLLCLPSS HHHHHHHHHHHCCCC	14.42	26657352
1007	Phosphorylation	KSLLCLPSSISCAQT HHHHHCCCCCCCCCC	27.62	27251275
1008	Phosphorylation	SLLCLPSSISCAQTP HHHHCCCCCCCCCCC	19.31	27251275
1010	Phosphorylation	LCLPSSISCAQTPCI HHCCCCCCCCCCCCC	12.83	27251275
1023	Phosphorylation	CIPKEGASPTSSSNE CCCCCCCCCCCCCCC	39.30	28450419
1025	Phosphorylation	PKEGASPTSSSNEDS CCCCCCCCCCCCCCH	38.45	28450419
1026	Phosphorylation	KEGASPTSSSNEDSA CCCCCCCCCCCCCHH	34.84	28450419
1027	Phosphorylation	EGASPTSSSNEDSAA CCCCCCCCCCCCHHC	39.39	28450419
1028	Phosphorylation	GASPTSSSNEDSAAN CCCCCCCCCCCHHCC	43.96	28450419
1032	Phosphorylation	TSSSNEDSAANGSAE CCCCCCCHHCCCCHH	24.09	28450419
1037	Phosphorylation	EDSAANGSAETSALD CCHHCCCCHHHHHHH	23.80	26657352
1040	Phosphorylation	AANGSAETSALDTGF HCCCCHHHHHHHHCC	21.01	26657352
1041	Phosphorylation	ANGSAETSALDTGFS CCCCHHHHHHHHCCC	20.52	28450419
1045	Phosphorylation	AETSALDTGFSLNLS HHHHHHHHCCCCCHH	40.76	28450419
1057	Phosphorylation	NLSELREYTEGLTEA CHHHHHHHHCCCCCC	12.03	29978859
1058	Phosphorylation	LSELREYTEGLTEAK HHHHHHHHCCCCCCC	20.87	28857561
1062	Phosphorylation	REYTEGLTEAKEDDD HHHHCCCCCCCCCCC	44.76	30108239
1073	Phosphorylation	EDDDGDHSSLQSGQS CCCCCCCCHHHHCHH	37.17	30108239
1074	Phosphorylation	DDDGDHSSLQSGQSV CCCCCCCHHHHCHHH	27.32	26657352
1077	Phosphorylation	GDHSSLQSGQSVISL CCCCHHHHCHHHHHH	44.06	30108239
1080	Phosphorylation	SSLQSGQSVISLLSS CHHHHCHHHHHHCCH	25.58	30108239
1083	Phosphorylation	QSGQSVISLLSSEEL HHCHHHHHHCCHHHH	22.54	29978859
1086	Phosphorylation	QSVISLLSSEELKKL HHHHHHCCHHHHHHH	40.78	29978859
1087	Phosphorylation	SVISLLSSEELKKLI HHHHHCCHHHHHHHH	34.75	29978859
1169	Phosphorylation	VLSINGKSLKGTTHH EEEECCEECCCCCHH	36.39	29978859
1195	Phosphorylation	PRQAVIVTRKLTPEA CCCEEEEEECCCHHH	15.80	24043423
1247	Phosphorylation	MSAGLGFSLEGGKGS ECCCCCCEEECCCCC	24.58	27251275
1254	Phosphorylation	SLEGGKGSLHGDKPL EEECCCCCCCCCCCE	22.22	27251275
1259	Ubiquitination	KGSLHGDKPLTINRI CCCCCCCCCEEHHHH	46.66	-
1275	O-linked_Glycosylation	KGAASEQSETVQPGD CCCCCCCCCCCCCCH	31.05	27655845
1277	O-linked_Glycosylation	AASEQSETVQPGDEI CCCCCCCCCCCCHHH	29.68	27655845
1305	Ubiquitination	FEAWNIIKALPDGPV HHHHHHHHHCCCCCE	39.82	-
1320	Phosphorylation	TIVIRRKSLQSKETT EEEEEECCCCCCCCC	29.81	-
1324	Ubiquitination	RRKSLQSKETTAAGD EECCCCCCCCCCCCC	46.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
144	S	Phosphorylation	Kinase	MK01	P28482	PhosphoELM
144	S	Phosphorylation	Kinase	MK03	P27361	PhosphoELM
743	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
757	T	Phosphorylation	Kinase	CDK1	P06493	PSP
845	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
845	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYPT1_HUMAN	PPP1R12A	physical	12923170
USBP1_HUMAN	USHBP1	physical	16189514
SSA27_HUMAN	SSSCA1	physical	16189514
DMRTB_HUMAN	DMRTB1	physical	16189514
FBLN4_HUMAN	EFEMP2	physical	16189514
MYPT2_HUMAN	PPP1R12B	physical	12923170
PP12C_HUMAN	PPP1R12C	physical	12923170
IL16_HUMAN	IL16	physical	7910967
HDAC3_HUMAN	HDAC3	physical	18097041
HSP7C_HUMAN	HSPA8	physical	18097041
DMRTB_HUMAN	DMRTB1	physical	19060904
GABP1_HUMAN	GABPB1	physical	19060904
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
TRIP6_HUMAN	TRIP6	physical	21516116
RN169_HUMAN	RNF169	physical	28514442
NRBP2_HUMAN	NRBP2	physical	28514442
ZN148_HUMAN	ZNF148	physical	28514442
KCC1A_HUMAN	CAMK1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.