PKDRE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKDRE_HUMAN
• UniProt AC: Q9NTG1
• Protein Name: Polycystic kidney disease and receptor for egg jelly-related protein
• Gene Name: PKDREJ
• Organism: Homo sapiens (Human).
• Sequence Length: 2253
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Description: May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm..
• Protein Sequence: MRPGPALLLLGVGLSLSVGRLPLPPVPRGAQAAVSGAPGGLLRGAPGLGVRGGRALLSLRPSAVRAGGAVLSGRGSLCFPHGGTGRRWYCLDLRVLLSAQRLPWPAAPALALVDLQLSARGGRLSLTWSVRLPRSPGRLAWAFRLRLLGPGAARPASPAARVSPRSAAPGPRPQQGFVARTECPTDGPARVMLQAVNSSSHRAVESSVSCQINACVIQRVRINTDQKGAPVRLSMQAEATINASVQLDCPAARAIAQYWQVFSVPAVGQAPDWTQPLDLPQLEIRNSPLFIHIPNNSLQWGVYVFNFTVSITTGNPKMPEVKDSDAVYVWIVRSSLQAVMLGDANITANFTEQLILDGSTSSDPDADSPLQGLQFFWYCTTDPRNYGGDRIILGSKEVCHPEQANLKWPWASGPVLTLLPETLKGDHVYFFRMVIRKDSRTAFSDKRVHVLQGPKAIAHITCIENCERNFIVSDRFSLFLNCTNCASRDFYKWSILSSSGGEMLFDWMGETVTGRNGAYLSIKAFAFRHFLEAEFSISLYLACWSGVTSVFRHSFIINHGPQIGECKINPAKGIALITKFVVQCSNFRDKHVPLTYKIIVSDLHSVGEISSVKENTLGTILYLGPQSTVPPSFLPVGMLASQYGLKIYAQVYDSLGAFSQVTLHATAQAPTDKNSSKTVLNQLLSFTVGPSSLLSTLIQKKDFLPAGYLLYIVASVLNNMKTELPLRDDRVNLRKHLIDQSFLLPVSTLVEIGQVVMTITKLTQKPSEFTWDAQKRATMRVWQANQALQEYQQKDKRFRSEQIEIVSTGILMSLSNILKMTSPHQVVKDPFYVIESLSDTILANKVPGNKTTSMRTPNFNMYVKKVEKWGINQLFRNEKHCRNCFYPTLNVSSVPGLSANGPISTMFCDFTNDLFPWLNDQENTSVEVSGFRMTGVADNGSVLEITPDVAEVYLVRKNLTFAAFNLTVGPNSEVDGSLKKTTGGFSFQVDSTVLREVLVHIVTEVMVLFTVLVYTGSQITPTALVATFLVPHDIPPFASQSALFDPACTVKKARVVCLPVSLLQLIAQHSHSPHCTVSIVLQAPRFVMKLNDKLVRISIFSVQCLDMYGIQSEWREGYCILGEKTSWYEVHCICKNVVRARRQLGTIGLTGIHLHTHYVMAKVIVIPNPVDLRLNIIKSLHQNPVTLFTVLFIILLYVGLAFWALYRDEMDQHLRGHVIVLPDNDPYDNLCYLVTIFTGSRWGSGTRANVFVQLRGTVSTSDVHCLSHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSRIKVENLFSRHIWLFICQKWLSVDTTLDRTFHVTHPDERLTRKDFFFIDVSSNLRKNHMWFSIFASVVAKTFNRLQRLSCCLAMLLSSLLCNIMFFNLNRQEQTESRERKYMRSMMIGIESVLITIPVQLLITFLFTCSQRKPQADLKEVSPQKHPLMSEASEHWEEYLRKWHAYETAKVHPREVAKPASKGKPRLPKASPKATSKPKHRHRKAQIKTPETLGPNTNSNNNIEDDQDVHSEQHPSQKDLQQLKKKPRIVLPWWCVYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLSGFRTNKPKYCKNLSWSTKYKYTEIRLDGMRMHPEEMQRIHDQIVRIRGTRMYQPLTEDEIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYNQFIRDRFSMDLATVTKLEDIYRWLNSVLLPLLHNDLNPTFLPESSSKILGLPLMRQVRAKSSEKMCLPAEKFVQNSIRREIHCHPKYGIDPEDTKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLYYSYGLLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLADFDRKASAEIYLYVAILIFFLAYVVDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGYLVFGQHEWNYSNLIHSTQTVFSYCVSAFQNTEFSNNRILGVLFLSSFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFLTSQSKAKDEPEFFIDMLYGQPEKNSHRYLGLKTRNINGKKMVYLVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	LLLGVGLSLSVGRLP EEEECCEECCCCCCC	16.81	22210691
17	Phosphorylation	LGVGLSLSVGRLPLP EECCEECCCCCCCCC	21.10	22210691
58	Phosphorylation	RGGRALLSLRPSAVR CCCEEEEEECHHHHH	24.15	24719451
60	Methylation	GRALLSLRPSAVRAG CEEEEEECHHHHHCC	21.54	115368699
62	Phosphorylation	ALLSLRPSAVRAGGA EEEEECHHHHHCCCC	32.72	-
65	Methylation	SLRPSAVRAGGAVLS EECHHHHHCCCCEEC	27.51	115368703
72	Phosphorylation	RAGGAVLSGRGSLCF HCCCCEECCCCCEEC	21.61	24719451
98	Phosphorylation	LDLRVLLSAQRLPWP EEHHHHHHCCCCCCC	20.42	-
125	Phosphorylation	SARGGRLSLTWSVRL HHCCCEEEEEEEEEC	23.53	27251275
127	Phosphorylation	RGGRLSLTWSVRLPR CCCEEEEEEEEECCC	16.59	27251275
129	Phosphorylation	GRLSLTWSVRLPRSP CEEEEEEEEECCCCC	7.66	27251275
135	Phosphorylation	WSVRLPRSPGRLAWA EEEECCCCCCCEEEE	29.75	27251275
157	Phosphorylation	PGAARPASPAARVSP CCCCCCCCCCCCCCC	20.11	26657352
163	Phosphorylation	ASPAARVSPRSAAPG CCCCCCCCCCCCCCC	14.72	26657352
197	N-linked_Glycosylation	RVMLQAVNSSSHRAV HHHEEEECCCCCCCC	38.91	UniProtKB CARBOHYD
198	Phosphorylation	VMLQAVNSSSHRAVE HHEEEECCCCCCCCC	26.98	25954137
199	Phosphorylation	MLQAVNSSSHRAVES HEEEECCCCCCCCCC	25.59	23403867
200	Phosphorylation	LQAVNSSSHRAVESS EEEECCCCCCCCCCC	19.47	23403867
206	Phosphorylation	SSHRAVESSVSCQIN CCCCCCCCCCHHEEE	29.46	25954137
207	Phosphorylation	SHRAVESSVSCQINA CCCCCCCCCHHEEEE	12.44	25954137
209	Phosphorylation	RAVESSVSCQINACV CCCCCCCHHEEEEEE	11.40	25954137
242	N-linked_Glycosylation	MQAEATINASVQLDC EEEEEEEEEEEECCC	23.08	UniProtKB CARBOHYD
295	N-linked_Glycosylation	PLFIHIPNNSLQWGV CEEEECCCCCEEEEE	50.55	UniProtKB CARBOHYD
306	N-linked_Glycosylation	QWGVYVFNFTVSITT EEEEEEEEEEEEEEC	22.95	UniProtKB CARBOHYD
313	Phosphorylation	NFTVSITTGNPKMPE EEEEEEECCCCCCCC	33.04	-
345	N-linked_Glycosylation	AVMLGDANITANFTE CHHHCCCEEECCCEE	36.56	UniProtKB CARBOHYD
349	N-linked_Glycosylation	GDANITANFTEQLIL CCCEEECCCEEEEEE	35.40	UniProtKB CARBOHYD
386	Phosphorylation	CTTDPRNYGGDRIIL ECCCCCCCCCCEEEE	24.62	-
439	Phosphorylation	RMVIRKDSRTAFSDK EEEEECCCCCCCCCC	34.27	29457462
481	N-linked_Glycosylation	DRFSLFLNCTNCASR CCCHHHCCCCCCCCC	24.19	UniProtKB CARBOHYD
554	Phosphorylation	VTSVFRHSFIINHGP CHHHHCCEEHHCCCC	17.55	23532336
578	Phosphorylation	AKGIALITKFVVQCS HCCEEEEEEEHHHCC	21.19	22210691
585	Phosphorylation	TKFVVQCSNFRDKHV EEEHHHCCCCCCCCC	23.16	22210691
654	Phosphorylation	IYAQVYDSLGAFSQV EEEEHHHHCCCCEEE	15.83	24719451
659	Phosphorylation	YDSLGAFSQVTLHAT HHHCCCCEEEEEEEE	24.17	24719451
671	Phosphorylation	HATAQAPTDKNSSKT EEEECCCCCCCCCHH	63.72	24719451
674	N-linked_Glycosylation	AQAPTDKNSSKTVLN ECCCCCCCCCHHHHH	55.09	UniProtKB CARBOHYD
692	Phosphorylation	SFTVGPSSLLSTLIQ HCCCCHHHHHHHHHH	36.14	-
695	Phosphorylation	VGPSSLLSTLIQKKD CCHHHHHHHHHHCCC	26.85	-
696	Phosphorylation	GPSSLLSTLIQKKDF CHHHHHHHHHHCCCC	28.05	-
708	Phosphorylation	KDFLPAGYLLYIVAS CCCCCHHHHHHHHHH	8.81	-
711	Phosphorylation	LPAGYLLYIVASVLN CCHHHHHHHHHHHHH	7.25	-
715	Phosphorylation	YLLYIVASVLNNMKT HHHHHHHHHHHCCCC	19.08	-
722	Phosphorylation	SVLNNMKTELPLRDD HHHHCCCCCCCCCCC	31.80	-
747	Phosphorylation	QSFLLPVSTLVEIGQ HHHHEEHHHHHHHHH	17.68	-
748	Phosphorylation	SFLLPVSTLVEIGQV HHHEEHHHHHHHHHH	34.75	-
807	Phosphorylation	SEQIEIVSTGILMSL HHHHHHHHHHHHHHH	26.95	24850871
808	Phosphorylation	EQIEIVSTGILMSLS HHHHHHHHHHHHHHH	19.83	30619164
813	Phosphorylation	VSTGILMSLSNILKM HHHHHHHHHHHHHHC	25.79	24850871
815	Phosphorylation	TGILMSLSNILKMTS HHHHHHHHHHHHCCC	17.95	24850871
849	N-linked_Glycosylation	LANKVPGNKTTSMRT HCCCCCCCCCCCCCC	32.22	UniProtKB CARBOHYD
862	Phosphorylation	RTPNFNMYVKKVEKW CCCCHHHEEEEHHHC	15.38	29759185
890	N-linked_Glycosylation	NCFYPTLNVSSVPGL CCCCCCCCHHHCCCC	33.82	UniProtKB CARBOHYD
923	N-linked_Glycosylation	PWLNDQENTSVEVSG HHHCCCCCCEEEEEC	31.83	UniProtKB CARBOHYD
939	N-linked_Glycosylation	RMTGVADNGSVLEIT EEEEECCCCCEEEEC	34.60	UniProtKB CARBOHYD
958	N-linked_Glycosylation	EVYLVRKNLTFAAFN EEEEEECCEEEEEEE	33.48	UniProtKB CARBOHYD
965	N-linked_Glycosylation	NLTFAAFNLTVGPNS CEEEEEEEEEECCCC	30.03	UniProtKB CARBOHYD
992	Phosphorylation	FSFQVDSTVLREVLV CEEEECHHHHHHHHH	21.06	24719451
1295	Phosphorylation	SDLGDIHSIRVWHNN HHCCCCEEEEEEECC	16.66	24719451
1374	Phosphorylation	RKNHMWFSIFASVVA CCCCCHHHHHHHHHH	10.98	-
1378	Phosphorylation	MWFSIFASVVAKTFN CHHHHHHHHHHHHHH	13.33	-
1383	Phosphorylation	FASVVAKTFNRLQRL HHHHHHHHHHHHHHH	19.19	-
1463	Phosphorylation	QADLKEVSPQKHPLM CCCHHHCCCCCCCCH	23.78	28122231
1520	Acetylation	PKATSKPKHRHRKAQ CCCCCCCCCCCCCCC	57.94	7707259
1643	Phosphorylation	FRTNKPKYCKNLSWS CCCCCCCCCCCCCCC	19.72	-
1683	Phosphorylation	QIVRIRGTRMYQPLT HHHHHCCCCCCCCCC	11.47	28509920
1748	Phosphorylation	QFIRDRFSMDLATVT HHHHHCCCCCHHHHH	16.57	26270265
1753	Phosphorylation	RFSMDLATVTKLEDI CCCCCHHHHHCHHHH	35.69	26270265
1755	Phosphorylation	SMDLATVTKLEDIYR CCCHHHHHCHHHHHH	26.09	26270265
1761	Phosphorylation	VTKLEDIYRWLNSVL HHCHHHHHHHHHHCH	14.20	26270265
1801	Phosphorylation	MRQVRAKSSEKMCLP HHHHHHHCCCCCCCC	42.62	-
1802	Phosphorylation	RQVRAKSSEKMCLPA HHHHHHCCCCCCCCH	40.30	-
1834	Phosphorylation	YGIDPEDTKNYSGFW CCCCHHHCCCCCCCC	21.37	-
1836	N-linked_Glycosylation	IDPEDTKNYSGFWNE CCHHHCCCCCCCCCH	37.99	UniProtKB CARBOHYD
1893	N-linked_Glycosylation	FPEQQRFNSTLRLKE CCHHHHCCCEECHHH	35.95	UniProtKB CARBOHYD
1944	N-linked_Glycosylation	VSQLGVVNTSISLHS HHHCCCCCEEEEEEE	26.21	UniProtKB CARBOHYD
2030	Phosphorylation	ATGIIRFYLSNPEDF HHCCHHHHCCCHHHC	10.20	28450419
2032	Phosphorylation	GIIRFYLSNPEDFIP CCHHHHCCCHHHCCC	38.67	28450419
2173	Phosphorylation	LFQAVILSAYEEMKQ HHHHHHHHHHHHHCC	20.06	-
2183	Phosphorylation	EEMKQPVYEEPSDEV HHHCCCCCCCCCHHH	22.66	24043423
2187	Phosphorylation	QPVYEEPSDEVEAMT CCCCCCCCHHHHHHH	50.08	24043423
2194	Phosphorylation	SDEVEAMTYLCRKLR CHHHHHHHHHHHHHH	22.01	24043423
2195	Phosphorylation	DEVEAMTYLCRKLRT HHHHHHHHHHHHHHH	7.24	24043423
2225	Phosphorylation	EFFIDMLYGQPEKNS CCHHHHHCCCCCCCC	13.69	22817900
2232	Phosphorylation	YGQPEKNSHRYLGLK CCCCCCCCCCEECEE	22.02	27251275
2235	Phosphorylation	PEKNSHRYLGLKTRN CCCCCCCEECEEEEC	10.33	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKDRE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKDRE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKDRE_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PKDRE_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.