SHSA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHSA2_HUMAN
• UniProt AC: Q6UWI4
• Protein Name: Protein shisa-2 homolog
• Gene Name: SHISA2
• Organism: Homo sapiens (Human).
• Sequence Length: 295
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
• Protein Description: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling..
• Protein Sequence: MWGARRSSVSSSWNAASLLQLLLAALLAAGARASGEYCHGWLDAQGVWRIGFQCPERFDGGDATICCGSCALRYCCSSAEARLDQGGCDNDRQQGAGEPGRADKDGPDGSAVPIYVPFLIVGSVFVAFIILGSLVAACCCRCLRPKQDPQQSRAPGGNRLMETIPMIPSASTSRGSSSRQSSTAASSSSSANSGARAPPTRSQTNCCLPEGTMNNVYVNMPTNFSVLNCQQATQIVPHQGQYLHPPYVGYTVQHDSVPMTAVPPFMDGLQPGYRQIQSPFPHTNSEQKMYPAVTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	LAAGARASGEYCHGW HHHHHHHCCCCCCCE	26.97	-
37	Phosphorylation	GARASGEYCHGWLDA HHHHCCCCCCCEECC	8.02	-
169	Phosphorylation	ETIPMIPSASTSRGS HHCCCCCCCCCCCCC	24.75	24850871
171	Phosphorylation	IPMIPSASTSRGSSS CCCCCCCCCCCCCCC	31.11	24850871
172	Phosphorylation	PMIPSASTSRGSSSR CCCCCCCCCCCCCCC	23.35	24850871
173	Phosphorylation	MIPSASTSRGSSSRQ CCCCCCCCCCCCCCC	31.95	22210691
176	Phosphorylation	SASTSRGSSSRQSST CCCCCCCCCCCCCCC	24.83	21955146
177	Phosphorylation	ASTSRGSSSRQSSTA CCCCCCCCCCCCCCC	32.15	22210691
178	Phosphorylation	STSRGSSSRQSSTAA CCCCCCCCCCCCCCC	35.72	21955146
181	Phosphorylation	RGSSSRQSSTAASSS CCCCCCCCCCCCCCC	28.66	21955146
182	Phosphorylation	GSSSRQSSTAASSSS CCCCCCCCCCCCCCC	17.46	21955146
183	Phosphorylation	SSSRQSSTAASSSSS CCCCCCCCCCCCCCC	31.33	21955146
186	Phosphorylation	RQSSTAASSSSSANS CCCCCCCCCCCCCCC	28.43	21955146
187	Phosphorylation	QSSTAASSSSSANSG CCCCCCCCCCCCCCC	29.52	21955146
188	Phosphorylation	SSTAASSSSSANSGA CCCCCCCCCCCCCCC	26.30	21955146
189	Phosphorylation	STAASSSSSANSGAR CCCCCCCCCCCCCCC	35.10	21955146
190	Phosphorylation	TAASSSSSANSGARA CCCCCCCCCCCCCCC	33.16	21955146
193	Phosphorylation	SSSSSANSGARAPPT CCCCCCCCCCCCCCC	33.28	21955146
283	Phosphorylation	IQSPFPHTNSEQKMY CCCCCCCCCCCCCCE	40.45	27251275
285	Phosphorylation	SPFPHTNSEQKMYPA CCCCCCCCCCCCEEC	42.43	30576142
290	Phosphorylation	TNSEQKMYPAVTV-- CCCCCCCEECCCC--	8.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHSA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHSA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHSA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PGES2_HUMAN	PTGES2	physical	26186194
PGES2_HUMAN	PTGES2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.