IP6K2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IP6K2_HUMAN
• UniProt AC: Q9UHH9
• Protein Name: Inositol hexakisphosphate kinase 2
• Gene Name: IP6K2
• Organism: Homo sapiens (Human).
• Sequence Length: 426
• Subcellular Localization: Nucleus .
• Protein Description: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4..
• Protein Sequence: MSPAFRAMDVEPRAKGVLLEPFVHQVGGHSCVLRFNETTLCKPLVPREHQFYETLPAEMRKFTPQYKGVVSVRFEEDEDRNLCLIAYPLKGDHGIVDIVDNSDCEPKSKLLRWTTNKKHHVLETEKTPKDWVRQHRKEEKMKSHKLEEEFEWLKKSEVLYYTVEKKGNISSQLKHYNPWSMKCHQQQLQRMKENAKHRNQYKFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSVQGFKEALFQFFHNGRYLRRELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGKERPEVVLDSDAEDLEDLSEESADESAGAYAYKPIGASSVDVRMIDFAHTTCRLYGEDTVVHEGQDAGYIFGLQSLIDIVTEISEESGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 4)	Phosphorylation	-	25.57	21955146
2	Phosphorylation	------MSPAFRAMD ------CCCCCCCCC	25.57	24719451
9 (in isoform 4)	Phosphorylation	-	40.41	-
9	Phosphorylation	SPAFRAMDVEPRAKG CCCCCCCCCCCCCCC	40.41	-
12	Phosphorylation	FRAMDVEPRAKGVLL CCCCCCCCCCCCEEE	41.18	-
12 (in isoform 4)	Phosphorylation	-	41.18	-
15	Ubiquitination	MDVEPRAKGVLLEPF CCCCCCCCCEEEECC	51.32	-
42	Ubiquitination	FNETTLCKPLVPREH ECCCCCCCCCCCCCH	44.49	-
52	Phosphorylation	VPREHQFYETLPAEM CCCCHHHHHHCCHHH	11.05	27642862
61	Ubiquitination	TLPAEMRKFTPQYKG HCCHHHHHCCCCCCC	52.89	-
67 (in isoform 1)	Ubiquitination	-	39.73	21906983
67	Ubiquitination	RKFTPQYKGVVSVRF HHCCCCCCCEEEEEE	39.73	21906983
71	Phosphorylation	PQYKGVVSVRFEEDE CCCCCEEEEEECCCC	12.74	24719451
87	Phosphorylation	RNLCLIAYPLKGDHG CCEEEEEEECCCCCC	11.34	-
90	Ubiquitination	CLIAYPLKGDHGIVD EEEEEECCCCCCEEE	58.76	-
118	Ubiquitination	LRWTTNKKHHVLETE HHCCCCCCCCCEECC	40.80	-
125 (in isoform 4)	Phosphorylation	-	45.62	24719451
126	Ubiquitination	HHVLETEKTPKDWVR CCCEECCCCHHHHHH	77.02	-
128 (in isoform 5)	Phosphorylation	-	43.61	24719451
129	Ubiquitination	LETEKTPKDWVRQHR EECCCCHHHHHHHHH	70.25	-
145	Ubiquitination	EEKMKSHKLEEEFEW HHHHHHCHHHHHHHH	65.76	-
154 (in isoform 1)	Ubiquitination	-	56.16	21906983
154	Ubiquitination	EEEFEWLKKSEVLYY HHHHHHHHHCCEEEE	56.16	21906983
155	Ubiquitination	EEFEWLKKSEVLYYT HHHHHHHHCCEEEEE	50.07	-
160	Phosphorylation	LKKSEVLYYTVEKKG HHHCCEEEEEEEECC	11.41	27642862
165	Ubiquitination	VLYYTVEKKGNISSQ EEEEEEEECCCHHHH	62.74	-
166	Sumoylation	LYYTVEKKGNISSQL EEEEEEECCCHHHHC	43.62	-
166	Sumoylation	LYYTVEKKGNISSQL EEEEEEECCCHHHHC	43.62	-
166	Ubiquitination	LYYTVEKKGNISSQL EEEEEEECCCHHHHC	43.62	-
174	Ubiquitination	GNISSQLKHYNPWSM CCHHHHCCCCCCHHH	36.08	-
182	Ubiquitination	HYNPWSMKCHQQQLQ CCCCHHHHHHHHHHH	24.05	-
196	Ubiquitination	QRMKENAKHRNQYKF HHHHHHHHHHHHHHE	55.46	-
202	Ubiquitination	AKHRNQYKFILLENL HHHHHHHHEEEEECC	19.03	-
222	Ubiquitination	VPCVLDLKMGTRQHG CCEEEEECCCCCCCC	34.64	-
236	Ubiquitination	GDDASEEKAANQIRK CCCCCHHHHHHHHHH	49.07	-
243	Ubiquitination	KAANQIRKCQQSTSA HHHHHHHHHHHHCHH	37.72	-
279	Ubiquitination	MNKYHGRKLSVQGFK EEEECCEECCHHHHH	50.10	-
309	Ubiquitination	ELLGPVLKKLTELKA HHHHHHHHHHHHHHH	46.07	-
310	Ubiquitination	LLGPVLKKLTELKAV HHHHHHHHHHHHHHH	57.38	-
315	Ubiquitination	LKKLTELKAVLERQE HHHHHHHHHHHHCHH	30.16	-
347	Phosphorylation	RPEVVLDSDAEDLED CCEEEECCCHHHHHH	34.26	29523821
356	Phosphorylation	AEDLEDLSEESADES HHHHHHHCHHCCCCC	52.20	25921289
359	Phosphorylation	LEDLSEESADESAGA HHHHCHHCCCCCCCC	36.65	17379600
370	Ubiquitination	SAGAYAYKPIGASSV CCCCCCCCCCCCCEE	23.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
347	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
347	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
356	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
356	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IP6K2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IP6K2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	17379600
HS90A_HUMAN	HSP90AA1	physical	18195352
HS90B_HUMAN	HSP90AB1	physical	18195352
GTPB6_HUMAN	GTPBP6	physical	26186194
PGK2_HUMAN	PGK2	physical	28514442
RHOU_HUMAN	RHOU	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.