REXO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REXO1_HUMAN
• UniProt AC: Q8N1G1
• Protein Name: RNA exonuclease 1 homolog
• Gene Name: REXO1
• Organism: Homo sapiens (Human).
• Sequence Length: 1221
• Subcellular Localization: Nucleus .
• Protein Description: Seems to have no detectable effect on transcription elongation in vitro..
• Protein Sequence: MLRSTGFFRAIDCPYWSGAPGGPCRRPYCHFRHRGARGSGAPGDGGEAPPAAGLGYDPYNPELPKPPAQRENGTLGLGEEPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTREHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGLLSPDAGYQPTPLAAPAEPGSKYSLASLDRGQGRGGGGGGALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSEDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKETAVQCDVGDLQPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPSPAPSSSSSSSSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNPRLAAAPTGAKRTLAASGSQSSNGPEPGGQQLKTRTLSGMASKTTTTIIPKRIAHSPSLQSLKKPIIPKEFGGKVPTVIRQRYLNLFIEECLKFCTSNQEAIEKALNEEKVAYDRSPSKNIYLNVAVNTLKKLRGLAPSAVPGLSKTSGRRVVSHEVVLGGRLAAKTSFSLSRPSSPRVEDLKGAALYSRLREYLLTQDQLKENGYPFPHPERPGGAIIFTAEEKRPKDSSCRTCCRCGTEYLVSSSGRCIRDEECYYHWGRLRRNRVAGGWETQYMCCSAAAGSVGCQVAKQHVQDGRKERLEGFVKTFEKELSGDTHPGIYALDCEMSYTTYGLELTRVTVVDTDVHVVYDTFVKPDNEIVDYNTRFSGVTEADLADTSVTLRDVQAVLLSMFSADTILIGHSLESDLLALKVIHSTVVDTSVLFPHRLGLPYKRSLRNLMADYLRQIIQDNVDGHSSSEDAGACMHLVIWKVREDAKTKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	PPAAGLGYDPYNPEL CCCCCCCCCCCCCCC	20.84	-
59	Phosphorylation	AGLGYDPYNPELPKP CCCCCCCCCCCCCCC	40.21	-
121	Phosphorylation	ETTREHRSAEAPALA HHHHHHHHCCCCCCC	32.16	26074081
135	Phosphorylation	APRGPNASPTVGPDE CCCCCCCCCCCCCCC	27.95	26074081
137	Phosphorylation	RGPNASPTVGPDEDA CCCCCCCCCCCCCCC	35.28	22210691
151	Phosphorylation	AFPLAFDYSPGSHGL CCCEECCCCCCCCCC	15.43	28348404
152	Phosphorylation	FPLAFDYSPGSHGLL CCEECCCCCCCCCCC	25.32	28348404
155	Phosphorylation	AFDYSPGSHGLLSPD ECCCCCCCCCCCCCC	20.12	28348404
160	Phosphorylation	PGSHGLLSPDAGYQP CCCCCCCCCCCCCCC	26.27	28348404
165	Phosphorylation	LLSPDAGYQPTPLAA CCCCCCCCCCCCCCC	17.03	28348404
168	Phosphorylation	PDAGYQPTPLAAPAE CCCCCCCCCCCCCCC	18.53	28348404
184	Phosphorylation	GSKYSLASLDRGQGR CCCCCCEEECCCCCC	35.78	28555341
191	Methylation	SLDRGQGRGGGGGGA EECCCCCCCCCCCCH	32.47	24129315
201	Phosphorylation	GGGGALEYVPKAVSQ CCCCHHHCCCCCCCC	23.93	-
207	Phosphorylation	EYVPKAVSQPRRHSR HCCCCCCCCCCCCCC	39.05	23312004
226	Phosphorylation	GKYVVDNSRPPTDLE CCEECCCCCCCCCCC	41.52	-
246	Phosphorylation	NYSARHLSRASSRDE HHHHHHHHHCCHHHH	21.48	-
250	Phosphorylation	RHLSRASSRDERAAK HHHHHCCHHHHHHHH	42.65	24825855
263	Methylation	AKRPRGSRGSEPYTP HHCCCCCCCCCCCCC	56.32	115491147
281	Phosphorylation	KLCDPFGSCDARFSD HHCCCCCCCCCCCCC	14.81	21815630
287	Phosphorylation	GSCDARFSDSEDEAA CCCCCCCCCCCCCCC	34.37	23927012
289	Phosphorylation	CDARFSDSEDEAATV CCCCCCCCCCCCCCC	45.83	23927012
295	Phosphorylation	DSEDEAATVPGNEPT CCCCCCCCCCCCCCC	33.99	23663014
302	Phosphorylation	TVPGNEPTTASTPKA CCCCCCCCCCCCCCH	28.90	20873877
303	Phosphorylation	VPGNEPTTASTPKAR CCCCCCCCCCCCCHH	29.35	28985074
305	Phosphorylation	GNEPTTASTPKARAD CCCCCCCCCCCHHCC	43.05	20873877
306	Phosphorylation	NEPTTASTPKARADP CCCCCCCCCCHHCCC	26.75	20873877
318	Phosphorylation	ADPEIKATGQPPSKE CCCCCCCCCCCCCHH	31.20	-
323	Phosphorylation	KATGQPPSKEGLEAE CCCCCCCCHHHCCCC	50.45	-
340	Phosphorylation	GLRETKETAVQCDVG CCCCHHCCEEECCCC	33.41	26074081
358	Phosphorylation	PPPAKPASPAQVQSS CCCCCCCCHHHHCCC	29.33	23401153
364	Phosphorylation	ASPAQVQSSQDGGCP CCHHHHCCCCCCCCC	30.98	23663014
365	Phosphorylation	SPAQVQSSQDGGCPK CHHHHCCCCCCCCCC	18.39	30108239
421	Phosphorylation	DKKGPQASSPRRKAE CCCCCCCCCHHHHCC	35.31	22496350
422	Phosphorylation	KKGPQASSPRRKAER CCCCCCCCHHHHCCC	25.99	25849741
438	Phosphorylation	EGTKKKPSSATPVAT CCCCCCCCCCCCCCC	41.29	30576142
439	Phosphorylation	GTKKKPSSATPVATS CCCCCCCCCCCCCCC	44.69	28555341
441	Phosphorylation	KKKPSSATPVATSGK CCCCCCCCCCCCCCC	21.90	28555341
445	Phosphorylation	SSATPVATSGKGRPD CCCCCCCCCCCCCCC	37.94	30576142
446	Phosphorylation	SATPVATSGKGRPDR CCCCCCCCCCCCCCC	28.86	30576142
459	Phosphorylation	DRPARRPSPTSGDSR CCCCCCCCCCCCCCC	38.71	30266825
461	Phosphorylation	PARRPSPTSGDSRPA CCCCCCCCCCCCCCC	50.07	30266825
462	Phosphorylation	ARRPSPTSGDSRPAA CCCCCCCCCCCCCCC	43.94	30266825
465	Phosphorylation	PSPTSGDSRPAAGRG CCCCCCCCCCCCCCC	43.63	23403867
484	O-linked_Glycosylation	LQLPDRKSTKAPSGK CCCCCCCCCCCCCCC	35.71	30379171
491	Acetylation	STKAPSGKLVERKAR CCCCCCCCHHHHHHH	54.41	25953088
499	Phosphorylation	LVERKARSLDEGASQ HHHHHHHHCCCCCCC	45.06	23401153
505	Phosphorylation	RSLDEGASQDAPKLK HHCCCCCCCCHHHHH	39.18	23312004
526	Phosphorylation	ADLFGDESEDEAAGP HHHHCCCCCCCCCCC	55.90	-
583	Phosphorylation	PSPAPSSSSSSSSST CCCCCCCCCCCCCCC	38.28	-
584	Phosphorylation	SPAPSSSSSSSSSTS CCCCCCCCCCCCCCC	35.87	-
585	Phosphorylation	PAPSSSSSSSSSTSS CCCCCCCCCCCCCCC	35.87	-
586	Phosphorylation	APSSSSSSSSSTSSA CCCCCCCCCCCCCCC	35.87	-
610	Phosphorylation	EKEVDFDSDPMEECL HHHCCCCCCHHHHHH	43.54	29255136
650	Phosphorylation	KSEEKGLSGLTTLFP HCHHCCCCHHHHHCC	40.19	-
664	O-linked_Glycosylation	PGQKRRISHLSKQGQ CCCHHHHHHHHHCCC	19.30	30379171
668	Methylation	RRISHLSKQGQEVEP HHHHHHHHCCCCCCC	65.88	115976533
718	Acetylation	APARLAEKSPSVHIS HHHHHHHHCCCCEEC	63.16	25953088
719	Phosphorylation	PARLAEKSPSVHISA HHHHHHHCCCCEECC	17.57	25159151
721	Phosphorylation	RLAEKSPSVHISAPG HHHHHCCCCEECCCC	33.16	28555341
749	Acetylation	AAAPTGAKRTLAASG CCCCCCCCCCHHHCC	47.46	25953088
751	Phosphorylation	APTGAKRTLAASGSQ CCCCCCCCHHHCCCC	21.75	-
757	Phosphorylation	RTLAASGSQSSNGPE CCHHHCCCCCCCCCC	25.13	-
771	Methylation	EPGGQQLKTRTLSGM CCCCHHCCEEEECCC	31.46	115976541
772	Phosphorylation	PGGQQLKTRTLSGMA CCCHHCCEEEECCCC	37.16	-
774	Phosphorylation	GQQLKTRTLSGMASK CHHCCEEEECCCCCC	30.43	27273156
776	Phosphorylation	QLKTRTLSGMASKTT HCCEEEECCCCCCCC	26.38	27273156
783	Phosphorylation	SGMASKTTTTIIPKR CCCCCCCCEEECCCC	26.19	27273156
794	Phosphorylation	IPKRIAHSPSLQSLK CCCCCCCCCCHHHCC	13.73	28450419
796	Phosphorylation	KRIAHSPSLQSLKKP CCCCCCCCHHHCCCC	41.89	28450419
799	Phosphorylation	AHSPSLQSLKKPIIP CCCCCHHHCCCCCCC	47.66	27732954
815	Phosphorylation	EFGGKVPTVIRQRYL HHCCCCCHHHHHHHH	31.39	23403867
821	Phosphorylation	PTVIRQRYLNLFIEE CHHHHHHHHHHHHHH	7.51	29083192
854	Phosphorylation	EKVAYDRSPSKNIYL CCCCCCCCCCCCEEE	30.54	28985074
867	Phosphorylation	YLNVAVNTLKKLRGL EEHHHHHHHHHHCCC	33.10	-
884	Methylation	SAVPGLSKTSGRRVV CCCCCCCCCCCCCEE	52.32	115976549
905	Phosphorylation	GGRLAAKTSFSLSRP CCEEEEECEEECCCC	30.22	28152594
906	Phosphorylation	GRLAAKTSFSLSRPS CEEEEECEEECCCCC	16.48	28152594
908	Phosphorylation	LAAKTSFSLSRPSSP EEEECEEECCCCCCC	25.79	28152594
910	Phosphorylation	AKTSFSLSRPSSPRV EECEEECCCCCCCCH	40.73	23401153
913	Phosphorylation	SFSLSRPSSPRVEDL EEECCCCCCCCHHHH	52.44	25159151
914	Phosphorylation	FSLSRPSSPRVEDLK EECCCCCCCCHHHHH	21.29	23401153
921	Ubiquitination	SPRVEDLKGAALYSR CCCHHHHHHHHHHHH	59.84	29967540
926	Phosphorylation	DLKGAALYSRLREYL HHHHHHHHHHHHHHH	6.24	23312004
927	Phosphorylation	LKGAALYSRLREYLL HHHHHHHHHHHHHHH	26.20	24719451
968	Phosphorylation	EEKRPKDSSCRTCCR CCCCCCCCCCCCCCC	37.15	-
969	Phosphorylation	EKRPKDSSCRTCCRC CCCCCCCCCCCCCCC	20.11	-
972	Phosphorylation	PKDSSCRTCCRCGTE CCCCCCCCCCCCCCE	21.93	-
978	Phosphorylation	RTCCRCGTEYLVSSS CCCCCCCCEEEECCC	25.69	-
1053	Phosphorylation	KTFEKELSGDTHPGI HHHHHHHCCCCCCCE	35.40	23532336
1121	Phosphorylation	DLADTSVTLRDVQAV HHCCCCCCHHHHHHH	18.82	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REXO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REXO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REXO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELOA1_HUMAN	TCEB3	physical	12943681

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358, AND MASSSPECTROMETRY.
PubMed: 18220336