LRIG3_HUMAN - dbPTM
LRIG3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRIG3_HUMAN
UniProt AC Q6UXM1
Protein Name Leucine-rich repeats and immunoglobulin-like domains protein 3
Gene Name LRIG3
Organism Homo sapiens (Human).
Sequence Length 1119
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Cytoplasmic vesicle membrane
Single-pass type I membrane protein. Detected in cytoplasmic vesicles when coexpressed with ERBB4..
Protein Description May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity)..
Protein Sequence MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEADVEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSHPSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEENHICTFKQTLENYRTPNFQSYDLDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87PhosphorylationDLSHNRLSFIKASSM
CCCCCHHHHHHHHHC		22.9924719451
95PhosphorylationFIKASSMSHLQSLRE
HHHHHHCHHHHHHHE		24.0029083192
99PhosphorylationSSMSHLQSLREVKLN
HHCHHHHHHHEEECC		35.4429083192
122N-linked_GlycosylationNLGPVSANITLLSLA
CCCCCCCCEEEEHHC		21.92UniProtKB CARBOHYD
156N-linked_GlycosylationTLDLSSNNISELQTA
CCCCCCCCHHHHHHH		40.90UniProtKB CARBOHYD
274N-linked_GlycosylationILQLDHNNLTEITKG
EEECCCCCCHHHHHH		44.94UniProtKB CARBOHYD
359PhosphorylationDCAFRGLSSLKTLDL
HHHHCCCCCCCEEEC		36.1324719451
372PhosphorylationDLKNNEISWTIEDMN
ECCCCEEEEEEECCC		16.40-
374PhosphorylationKNNEISWTIEDMNGA
CCCEEEEEEECCCCC		14.01-
383PhosphorylationEDMNGAFSGLDKLRR
ECCCCCCCCHHHHHH		37.60-
442N-linked_GlycosylationKLQQLHLNTSSLLCD
HHHHHCCCHHHHHHH		27.45UniProtKB CARBOHYD
469N-linked_GlycosylationNNFQSFVNASCAHPQ
CCHHHHHCHHCCCCH		24.91UniProtKB CARBOHYD
514PhosphorylationTQSAIKGSNLSFICS
HHHCCCCCCEEEEEE		29.6026270265
515N-linked_GlycosylationQSAIKGSNLSFICSA
HHCCCCCCEEEEEEE		48.66UniProtKB CARBOHYD
517PhosphorylationAIKGSNLSFICSAAS
CCCCCCEEEEEEECC		19.4726270265
521PhosphorylationSNLSFICSAASSSDS
CCEEEEEEECCCCCC		23.2726270265
524PhosphorylationSFICSAASSSDSPMT
EEEEEECCCCCCCCE		30.0526270265
525PhosphorylationFICSAASSSDSPMTF
EEEEECCCCCCCCEE		33.1826270265
526PhosphorylationICSAASSSDSPMTFA
EEEECCCCCCCCEEE		39.3426270265
528PhosphorylationSAASSSDSPMTFAWK
EECCCCCCCCEEEEE		20.6526270265
531PhosphorylationSSSDSPMTFAWKKDN
CCCCCCCEEEEECCC		17.3726270265
598PhosphorylationYSVKAKLTVNMLPSF
EEEEEEEEEECCCCC		14.7723898821
604PhosphorylationLTVNMLPSFTKTPMD
EEEECCCCCCCCCCC		41.4024719451
608PhosphorylationMLPSFTKTPMDLTIR
CCCCCCCCCCCEEHH		22.3124300666
613PhosphorylationTKTPMDLTIRAGAMA
CCCCCCEEHHHHCCH		12.2624300666
688N-linked_GlycosylationSAGSISANATLTVLE
CCCCEECCEEEEEEC		27.02UniProtKB CARBOHYD
723PhosphorylationLQCIAGGSPPPKLNW
EHHHCCCCCCCCCCC		33.0624719451
729N-linked_GlycosylationGSPPPKLNWTKDDSP
CCCCCCCCCCCCCCC		50.96UniProtKB CARBOHYD
731PhosphorylationPPPKLNWTKDDSPLV
CCCCCCCCCCCCCCE		24.4227251275
775PhosphorylationEMSNTLGTERGNVRL
EEECCCCCCCCCEEE		26.1424719451
905N-linked_GlycosylationSGTCHIDNSSEADVE
CCEEECCCCCHHHHH		47.00UniProtKB CARBOHYD
938PhosphorylationLKGNVYGSDPFETYH
EECCEECCCCCCCCC		25.1529978859
943PhosphorylationYGSDPFETYHTGCSP
ECCCCCCCCCCCCCC		22.4528348404
944PhosphorylationGSDPFETYHTGCSPD
CCCCCCCCCCCCCCC		7.0928348404
946PhosphorylationDPFETYHTGCSPDPR
CCCCCCCCCCCCCCC		29.4828348404
949PhosphorylationETYHTGCSPDPRTVL
CCCCCCCCCCCCCEE		33.4129978859
960PhosphorylationRTVLMDHYEPSYIKK
CCEECCCCCCHHCCC		25.8527642862
963PhosphorylationLMDHYEPSYIKKKEC
ECCCCCCHHCCCCCC		27.7929978859
964PhosphorylationMDHYEPSYIKKKECY
CCCCCCHHCCCCCCC		27.7227642862
984PhosphorylationSEESCERSFSNISWP
CHHHHHHHCCCCCCH		15.6725159151
987N-linked_GlycosylationSCERSFSNISWPSHV
HHHHHCCCCCCHHHH		30.24UniProtKB CARBOHYD
989PhosphorylationERSFSNISWPSHVRK
HHHCCCCCCHHHHHH		36.8723898821
996UbiquitinationSWPSHVRKLLNTSYS
CCHHHHHHHHHCCCC		57.12-
999N-linked_GlycosylationSHVRKLLNTSYSHNE
HHHHHHHHCCCCCCC		37.10UniProtKB CARBOHYD
1000PhosphorylationHVRKLLNTSYSHNEG
HHHHHHHCCCCCCCC		29.0725627689
1001PhosphorylationVRKLLNTSYSHNEGP
HHHHHHCCCCCCCCC		24.4625159151
1011UbiquitinationHNEGPGMKNLCLNKS
CCCCCCHHCCCCCHH		53.32-
1016N-linked_GlycosylationGMKNLCLNKSSLDFS
CHHCCCCCHHHCCCC		40.96UniProtKB CARBOHYD
1018PhosphorylationKNLCLNKSSLDFSAN
HCCCCCHHHCCCCCC		34.75-
1019PhosphorylationNLCLNKSSLDFSANP
CCCCCHHHCCCCCCC		33.30-
1030PhosphorylationSANPEPASVASSNSF
CCCCCCCCHHCCCCC		29.00-
1053PhosphorylationRRPHLDAYSSFGQPS
CCCCCCCCCCCCCCC		12.4328152594
1054PhosphorylationRPHLDAYSSFGQPSD
CCCCCCCCCCCCCCC		22.4028152594
1055PhosphorylationPHLDAYSSFGQPSDC
CCCCCCCCCCCCCCC		22.2628152594
1073PhosphorylationAFYLKAHSSPDLDSG
EEEEEECCCCCCCCC		48.7228348404
1074PhosphorylationFYLKAHSSPDLDSGS
EEEEECCCCCCCCCC		16.7423312004
1079PhosphorylationHSSPDLDSGSEEDGK
CCCCCCCCCCCCCCC		52.0629255136
1081PhosphorylationSPDLDSGSEEDGKER
CCCCCCCCCCCCCCC		41.5929255136
1101UbiquitinationENHICTFKQTLENYR
HHCEEEHHHHHHHCC		24.99-
1114PhosphorylationYRTPNFQSYDLDT--
CCCCCCCCCCCCC--		19.2428348404
1115PhosphorylationRTPNFQSYDLDT---
CCCCCCCCCCCC---		15.1120736484
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRIG3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRIG3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRIG3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LRIG3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRIG3_HUMAN

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Related Literatures of Post-Translational Modification

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