SN12L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SN12L_HUMAN
• UniProt AC: Q6IEE8
• Protein Name: Schlafen family member 12-like
• Gene Name: SLFN12L
• Organism: Homo sapiens (Human).
• Sequence Length: 588
• Subcellular Localization: Membrane; Single-pass membrane protein.
• Protein Sequence: MDLARKEFLRGNGLAAGKMNISIDLDTNYAELVLNVGRVTLGENNRKKMKDCQLRKQQNENVSRAVCALLNSGGGVIKAEVENKGYSYKKDGIGLDLENSFSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQIATLSSSLYKRDVTSAKVMNASAALEFLKDMEKTGGRAYLRPEFPAKRACVDVQEESNMEALAADFFNRTELGYKEKLTFTESTHVEIKNFSTEKLLQRITEILPQYVSAFANTDGGYLFVGLNEDKEVIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGTINYLCKFLGVYDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQLTEKEWIQFMVDSEPVCEELPSPASTSSPVSQSYPLREYINFKIQPLRYHLPGLSEKITCAPKTFCRNLFSQHEGLKQLICEEMGSVNKGSLIFSRSWSLDLGLQENHKVLCDALLISQDKPPVLYTFHMVQDEEFKDYSTQTAQTLKQKLAKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYYWTTAQTMKDLEKALSNILPKENQIFLFVCLFRFCLFVCWFVCFFLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	AEVENKGYSYKKDGI EEEECCCCCCCCCCC	10.44	-
311	Phosphorylation	LCKFLGVYDKGRLCG HHHHHCCCCCCCCCH	52.56	-
488	Phosphorylation	QDEEFKDYSTQTAQT CCHHHCCCCHHHHHH	27.58	27732954
489	Phosphorylation	DEEFKDYSTQTAQTL CHHHCCCCHHHHHHH	22.35	27732954
490	Phosphorylation	EEFKDYSTQTAQTLK HHHCCCCHHHHHHHH	48.78	27732954
492	Phosphorylation	FKDYSTQTAQTLKQK HCCCCHHHHHHHHHH	2.33	27732954
502	Ubiquitination	TLKQKLAKIGGYTKK HHHHHHHHCCCCCHH	43.51	-
506	Phosphorylation	KLAKIGGYTKKVCVM HHHHCCCCCHHEEEE	4.04	-
509	Acetylation	KIGGYTKKVCVMTKI HCCCCCHHEEEEEEE	1.90	7380045
520	Phosphorylation	MTKIFYLSPEGKTSC EEEEEEECCCCCCCC	17.76	24260401
529	Phosphorylation	EGKTSCQYDLNSQVI CCCCCCEEECCCCEE	49.10	23879269
537	Phosphorylation	DLNSQVIYPESYYWT ECCCCEECCHHHEEC	30.34	23879269
557	Phosphorylation	KDLEKALSNILPKEN HHHHHHHHCCCCHHH	45.66	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SN12L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SN12L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SN12L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SN12L_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.