FBXL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL3_HUMAN
• UniProt AC: Q9UKT7
• Protein Name: F-box/LRR-repeat protein 3
• Gene Name: FBXL3
• Organism: Homo sapiens (Human).
• Sequence Length: 428
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly nuclear.
• Protein Description: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. [PubMed: 17463251]
• Protein Sequence: MKRGGRDSDRNSSEEGTAEKSKKLRTTNEHSQTCDWGNLLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIRHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GRDSDRNSSEEGTAE CCCCCCCCCCCCCHH	39.77	22210691
13	Phosphorylation	RDSDRNSSEEGTAEK CCCCCCCCCCCCHHH	43.12	29759185
20	Ubiquitination	SEEGTAEKSKKLRTT CCCCCHHHHHHCCCC	66.18	23503661
21	Phosphorylation	EEGTAEKSKKLRTTN CCCCHHHHHHCCCCC	26.91	22210691
26	Ubiquitination	EKSKKLRTTNEHSQT HHHHHCCCCCCCCCC	44.39	22817900
38	Ubiquitination	SQTCDWGNLLQDIIL CCCCCHHHHHHHHHH	33.07	21963094
49	Ubiquitination	DIILQVFKYLPLLDR HHHHHHHHHHHHHCH	47.20	21890473
52	Ubiquitination	LQVFKYLPLLDRAHA HHHHHHHHHHCHHHH	27.99	22817900
94	Phosphorylation	ATSYLKATHPELIKQ HHHHHHHHCHHHHHH	36.05	22673903
96	Ubiquitination	SYLKATHPELIKQII HHHHHHCHHHHHHHH	33.46	21963094
100	Ubiquitination	ATHPELIKQIIKRHS HHCHHHHHHHHHHCC	48.33	29967540
107	Phosphorylation	KQIIKRHSNHLQYVS HHHHHHCCCCEEEEE	29.94	29083192
112	Phosphorylation	RHSNHLQYVSFKVDS HCCCCEEEEEEEECC	12.38	29083192
114	Phosphorylation	SNHLQYVSFKVDSSK CCCEEEEEEEECCCH	17.89	29083192
116	Ubiquitination	HLQYVSFKVDSSKES CEEEEEEEECCCHHH	37.31	29967540
119	Phosphorylation	YVSFKVDSSKESAEA EEEEEECCCHHHHHH	46.42	29083192
120	Phosphorylation	VSFKVDSSKESAEAA EEEEECCCHHHHHHH	35.66	29083192
121	Ubiquitination	SFKVDSSKESAEAAC EEEECCCHHHHHHHH	60.69	29967540
169	Ubiquitination	SALTVVFVNSKSLSS EEEEEEEECCCCCCC	5.52	22817900
172	Ubiquitination	TVVFVNSKSLSSLKI EEEEECCCCCCCCCC	50.65	23503661
175	Phosphorylation	FVNSKSLSSLKIDDT EECCCCCCCCCCCCC	40.49	24719451
178	Ubiquitination	SKSLSSLKIDDTPVD CCCCCCCCCCCCCCC	46.14	21906983
182	Phosphorylation	SSLKIDDTPVDDPSL CCCCCCCCCCCCCCC	22.82	27067055
190	Ubiquitination	PVDDPSLKVLVANNS CCCCCCCEEEEECCC	37.55	21906983
199	Phosphorylation	LVANNSDTLKLLKMS EEECCCHHHHHHHHH	26.13	27067055
201	Ubiquitination	ANNSDTLKLLKMSSC ECCCHHHHHHHHHCC	54.59	21906983
204	Ubiquitination	SDTLKLLKMSSCPHV CHHHHHHHHHCCCCC	47.36	22817900
229	Ubiquitination	QCHGLRELALNYHLL HCCCHHHHHHHHHHC	5.48	21963094
248	Ubiquitination	LLALSSEKHVRLEHL HHHHCCCCCCCCEEE	49.72	21963094
284	Phosphorylation	WDAFIRHSPKVNLVM HHHHHHHCCCCCEEE	19.30	-
321	Ubiquitination	YFGRSVSKDVLGRVG ECCCCCCHHHHHCCC	50.10	21906983
362	Phosphorylation	AERCKNLSAIGLGEC HHHHCCCCCCCCCCC	27.51	27251275
372	Phosphorylation	GLGECEVSCSAFVEF CCCCCEECHHHHHHH	4.69	27251275
374	Phosphorylation	GECEVSCSAFVEFVK CCCEECHHHHHHHHH	19.75	27251275
381	Ubiquitination	SAFVEFVKMCGGRLS HHHHHHHHHHCCCHH	33.52	21963094
388	Phosphorylation	KMCGGRLSQLSIMEE HHHCCCHHHHHHHHH	27.93	26074081
391	Phosphorylation	GGRLSQLSIMEEVLI CCCHHHHHHHHHHHC	16.56	26074081
403	Phosphorylation	VLIPDQKYSLEQIHW HHCCCCCCCHHHHHH	16.92	26074081
404	Phosphorylation	LIPDQKYSLEQIHWE HCCCCCCCHHHHHHH	32.25	26074081
414	Ubiquitination	QIHWEVSKHLGRVWF HHHHHHHHHHCCCCC	48.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	10531035
SKP1_HUMAN	SKP1	physical	10531035
BTG1_HUMAN	BTG1	physical	22975506
BTG2_HUMAN	BTG2	physical	22975506
CRY1_HUMAN	CRY1	physical	17463251
CRY2_HUMAN	CRY2	physical	17463251
CUL1_HUMAN	CUL1	physical	22268729
CRY1_HUMAN	CRY1	physical	24085301
CUL1_HUMAN	CUL1	physical	24085301
SKP1_HUMAN	SKP1	physical	24085301
CRY2_HUMAN	CRY2	physical	24085301
RFX2_HUMAN	RFX2	physical	26186194
RFX1_HUMAN	RFX1	physical	26186194
CRY1_HUMAN	CRY1	physical	26186194
CRY2_HUMAN	CRY2	physical	27529127
CRY1_HUMAN	CRY1	physical	28514442
RFX2_HUMAN	RFX2	physical	28514442
RFX1_HUMAN	RFX1	physical	28514442
2A5D_HUMAN	PPP2R5D	physical	28514442
SKP1_HUMAN	SKP1	physical	28614300

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.