RFX2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX2_HUMAN
• UniProt AC: P48378
• Protein Name: DNA-binding protein RFX2
• Gene Name: RFX2
• Organism: Homo sapiens (Human).
• Sequence Length: 723
• Subcellular Localization: Nucleus . Cytoplasm . Mainly expressed in the nucleus and at lower level in cytoplasm.
• Protein Description: Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (By similarity). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. [PubMed: 10330134 Probably activates transcription of the testis-specific histone gene HIST1H1T (By similarity]
• Protein Sequence: MQNSEGGADSPASVALRPSAAAPPVPASPQRVLVQAASSNPKGAQMQPISLPRVQQVPQQVQPVQHVYPAQVQYVEGGDAVYTNGAIRTAYTYNPEPQMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVGITMDVGGSPIVSSAGAYLIHGGMDSTRHSLAHTSRSSPATLEMAIENLQKSEGITSHKSGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPMHQKPRYRPAQKTDSLGDSGSHSGLHSTPEQTMAVQSQHHQQYIDVSHVFPEFPAPDLGSFLLQDGVTLHDVKALQLVYRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCDPILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRLEQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGEFNDLASLSLTLLDKDDMGDEQRGSEAGPDARSLGEPLVKRERSDPNHSLQGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MQNSEGGADSP ----CCCCCCCCCCC	22.26	28857561
10	Phosphorylation	NSEGGADSPASVALR CCCCCCCCCCCCCCC	23.10	28857561
13	Phosphorylation	GGADSPASVALRPSA CCCCCCCCCCCCCCC	16.00	23186163
19	Phosphorylation	ASVALRPSAAAPPVP CCCCCCCCCCCCCCC	24.89	23186163
28	Phosphorylation	AAPPVPASPQRVLVQ CCCCCCCCCCEEEEE	18.59	28450419
38	Phosphorylation	RVLVQAASSNPKGAQ EEEEEHHHCCCCCCC	33.39	27174698
39	Phosphorylation	VLVQAASSNPKGAQM EEEEHHHCCCCCCCC	53.04	27174698
50	Phosphorylation	GAQMQPISLPRVQQV CCCCCCCCCCCCCCC	38.72	27174698
82	Phosphorylation	VEGGDAVYTNGAIRT EECCCEEEECCCEEE	9.01	-
93	Phosphorylation	AIRTAYTYNPEPQMY CEEEEEECCCCCCCC	18.95	-
100	Phosphorylation	YNPEPQMYAPSSTAS CCCCCCCCCCCCCCC	15.31	-
108	Phosphorylation	APSSTASYFEAPGGA CCCCCCCCEECCCCC	11.72	-
170	Phosphorylation	SLAHTSRSSPATLEM CHHCCCCCCHHHHHH	40.20	28450419
171	Phosphorylation	LAHTSRSSPATLEMA HHCCCCCCHHHHHHH	19.90	28450419
174	Phosphorylation	TSRSSPATLEMAIEN CCCCCHHHHHHHHHH	27.00	28450419
214	Phosphorylation	YETAEGVSLPRSSLY CCCCCCCCCCHHHHH	43.44	24719451
219	Phosphorylation	GVSLPRSSLYNHYLR CCCCCHHHHHHHHHH	35.83	-
221	Phosphorylation	SLPRSSLYNHYLRHC CCCHHHHHHHHHHHH	11.22	-
224	Phosphorylation	RSSLYNHYLRHCQEH HHHHHHHHHHHHHHC	11.20	-
243	Ubiquitination	VNAASFGKLIRSVFM CCHHHHHHHHHHHHH	38.44	-
276	Phosphorylation	GIRLKPDSPLNRLQE EEEECCCCCCHHHHH	39.55	25159151
416	Phosphorylation	GPTSLPASDEDPEGA CCCCCCCCCCCCCCC	39.32	-
514	Phosphorylation	FAQTLRRYTSLNHLA HHHHHHHHHCHHHHH	8.34	23312004
515	Phosphorylation	AQTLRRYTSLNHLAQ HHHHHHHHCHHHHHH	25.56	23312004
516	Phosphorylation	QTLRRYTSLNHLAQA HHHHHHHCHHHHHHH	20.45	23312004
631	Phosphorylation	IRDLTLRSAASFGSF HHHHHHHHHHHCCCH	31.16	28122231
634	Phosphorylation	LTLRSAASFGSFHLI HHHHHHHHCCCHHHH	29.83	28122231
677	Phosphorylation	GEFNDLASLSLTLLD ECHHHHHHHEEEECC	26.28	25311616
679	Phosphorylation	FNDLASLSLTLLDKD HHHHHHHEEEECCCC	19.47	25311616
681	Phosphorylation	DLASLSLTLLDKDDM HHHHHEEEECCCCCC	23.15	25311616
703	Phosphorylation	EAGPDARSLGEPLVK CCCCCHHHCCCCCHH	42.31	30206219
714	Phosphorylation	PLVKRERSDPNHSLQ CCHHCCCCCCCCCCC	53.30	24719451
719	Phosphorylation	ERSDPNHSLQGI--- CCCCCCCCCCCC---	29.09	22115753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RFX6_HUMAN	RFX6	physical	16189514
CA094_HUMAN	C1orf94	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.