BTG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTG1_HUMAN
• UniProt AC: P62324
• Protein Name: Protein BTG1
• Gene Name: BTG1
• Organism: Homo sapiens (Human).
• Sequence Length: 171
• Protein Description: Anti-proliferative protein..
• Protein Sequence: MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Ubiquitination	RCIRINHKMDPLIGQ EEEEEECCCCHHHHH	40.28	-
90	Phosphorylation	AAQRIGLSSQELFRL HHHHHCCCHHHHHHH	25.43	27251275
100	Phosphorylation	ELFRLLPSELTLWVD HHHHHCCCCCEEEEC	45.25	-
148	Phosphorylation	QMVDSRISCKEELLL EEECCCCCCCHHHHC	20.30	-
158	Phosphorylation	EELLLGRTSPSKNYN HHHHCCCCCCCCCCC	43.10	28355574
159	Phosphorylation	ELLLGRTSPSKNYNM HHHCCCCCCCCCCCC	26.30	25159151
161	Phosphorylation	LLGRTSPSKNYNMMT HCCCCCCCCCCCCCE	33.04	23403867
162	Ubiquitination	LGRTSPSKNYNMMTV CCCCCCCCCCCCCEE	67.83	-
164	Phosphorylation	RTSPSKNYNMMTVSG CCCCCCCCCCCEECC	14.26	26074081
168	Phosphorylation	SKNYNMMTVSG---- CCCCCCCEECC----	10.76	26074081
170	Phosphorylation	NYNMMTVSG------ CCCCCEECC------	29.62	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
159	S	Phosphorylation	Kinase	CDK2	P24941	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM1_HUMAN	PRMT1	physical	8663146
ANM1_HUMAN	PRMT1	physical	11856371
CNOT8_HUMAN	CNOT8	physical	16189514
CNOT7_HUMAN	CNOT7	physical	9820826
CNOT8_HUMAN	CNOT8	physical	11136725
CNOT7_HUMAN	CNOT7	physical	11136725
CNOT7_MOUSE	Cnot7	physical	9712883
CNOT7_HUMAN	CNOT7	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
CNOT8_HUMAN	CNOT8	physical	21900206
XRCC6_HUMAN	XRCC6	physical	21900206
CUL1_HUMAN	CUL1	physical	22975506
SKP1_HUMAN	SKP1	physical	22975506
SKP2_HUMAN	SKP2	physical	22975506
RN181_HUMAN	RNF181	physical	21988832
CNOT8_HUMAN	CNOT8	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.