CMS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CMS1_HUMAN
• UniProt AC: Q9BQ75
• Protein Name: Protein CMSS1
• Gene Name: CMSS1
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Protein Sequence: MADDLGDEWWENQPTGAGSSPEASDGEGEGDTEVMQQETVPVPVPSEKTKQPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSRRLVIELEELNLPDSCFLKANDLTHSLSSYLKEICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQAQVKLLEKRVVHLGVGTPGRIKELVKQGGLNLSPLKFLVFDWNWRDQKLRRMMDIPEIRKEVFELLEMGVLSLCKSESLKLGLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MADDLGDEWWENQ --CCCCCCCCHHHCC		24719451
6 (in isoform 2)	Phosphorylation	-		24719451
15	Phosphorylation	EWWENQPTGAGSSPE CHHHCCCCCCCCCCC		28348404
19	Phosphorylation	NQPTGAGSSPEASDG CCCCCCCCCCCCCCC		28348404
20	Phosphorylation	QPTGAGSSPEASDGE CCCCCCCCCCCCCCC		28348404
24	Phosphorylation	AGSSPEASDGEGEGD CCCCCCCCCCCCCCC		28348404
32	Phosphorylation	DGEGEGDTEVMQQET CCCCCCCCCCCEECE		28348404
35	Ubiquitination	GEGDTEVMQQETVPV CCCCCCCCEECEECC		33845483
39	Phosphorylation	TEVMQQETVPVPVPS CCCCEECEECCCCCC		28348404
43	Ubiquitination	QQETVPVPVPSEKTK EECEECCCCCCCCCC		23000965
46	Phosphorylation	TVPVPVPSEKTKQPK EECCCCCCCCCCCCC		20873877
46	Ubiquitination	TVPVPVPSEKTKQPK EECCCCCCCCCCCCC		23000965
53	Ubiquitination	SEKTKQPKECFLIQP CCCCCCCCCCEECCC		33845483
59	Ubiquitination	PKECFLIQPKERKEN CCCCEECCCHHHCCC		29967540
61	Ubiquitination	ECFLIQPKERKENTT CCEECCCHHHCCCCC		23000965
64	Ubiquitination	LIQPKERKENTTKTR ECCCHHHCCCCCHHH		23000965
66	Ubiquitination	QPKERKENTTKTRKR CCHHHCCCCCHHHHH		33845483
70	Ubiquitination	RKENTTKTRKRRKKK HCCCCCHHHHHHHHH		29967540
77	Ubiquitination	TRKRRKKKITDVLAK HHHHHHHHHHHHHHH		29967540
79	Phosphorylation	KRRKKKITDVLAKSE HHHHHHHHHHHHHCC		28555341
79	Ubiquitination	KRRKKKITDVLAKSE HHHHHHHHHHHHHCC		23000965
82	Ubiquitination	KKKITDVLAKSEPKP HHHHHHHHHHCCCCC		23000965
84	Acetylation	KITDVLAKSEPKPGL HHHHHHHHCCCCCCC		26051181
84	Sumoylation	KITDVLAKSEPKPGL HHHHHHHHCCCCCCC		-
84	Ubiquitination	KITDVLAKSEPKPGL HHHHHHHHCCCCCCC		33845483
88	Trimethylation	VLAKSEPKPGLPEDL HHHHCCCCCCCCHHH		-
88	Methylation	VLAKSEPKPGLPEDL HHHHCCCCCCCCHHH		-
88	Ubiquitination	VLAKSEPKPGLPEDL HHHHCCCCCCCCHHH		29967540
88	Acetylation	VLAKSEPKPGLPEDL HHHHCCCCCCCCHHH		26051181
97	Ubiquitination	GLPEDLQKLMKDYYS CCCHHHHHHHHHHHH		23000965
100	Ubiquitination	EDLQKLMKDYYSSRR HHHHHHHHHHHHHCC		23000965
102	Phosphorylation	LQKLMKDYYSSRRLV HHHHHHHHHHHCCEE		25072903
103	Phosphorylation	QKLMKDYYSSRRLVI HHHHHHHHHHCCEEE		25072903
124	Ubiquitination	LPDSCFLKANDLTHS CCCCEEECHHHHHHC		32142685
133	Phosphorylation	NDLTHSLSSYLKEIC HHHHHCHHHHHHHHC		25627689
137	Acetylation	HSLSSYLKEICPKWV HCHHHHHHHHCHHHH		26051181
142	Acetylation	YLKEICPKWVKLRKN HHHHHCHHHHHHHCC		25953088
142	Ubiquitination	YLKEICPKWVKLRKN HHHHHCHHHHHHHCC		32142685
167	Methylation	IICSSAVRALELIRS HHHHHHHHHHHHHHH		24129315
172	Ubiquitination	AVRALELIRSMTAFR HHHHHHHHHHHHHCC		29967540
174	Phosphorylation	RALELIRSMTAFRGD HHHHHHHHHHHCCCC		27251275
175	Ubiquitination	ALELIRSMTAFRGDG HHHHHHHHHHCCCCC		29967540
181	Ubiquitination	SMTAFRGDGKVIKLF HHHHCCCCCHHHHHH		29967540
190	Ubiquitination	KVIKLFAKHIKVQAQ HHHHHHHHHCHHHHH		29967540
190	Acetylation	KVIKLFAKHIKVQAQ HHHHHHHHHCHHHHH		-
193	Ubiquitination	KLFAKHIKVQAQVKL HHHHHHCHHHHHHHH		29967540
199	Ubiquitination	IKVQAQVKLLEKRVV CHHHHHHHHHHCCEE		23000965
203	Ubiquitination	AQVKLLEKRVVHLGV HHHHHHHCCEEEECC		23000965
212	Phosphorylation	VVHLGVGTPGRIKEL EEEECCCCHHHHHHH		20068231
217	Ubiquitination	VGTPGRIKELVKQGG CCCHHHHHHHHHCCC		23000965
221	Ubiquitination	GRIKELVKQGGLNLS HHHHHHHHCCCCCCC		23000965
228	Phosphorylation	KQGGLNLSPLKFLVF HCCCCCCCCCEEEEE		19664994

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CMS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CMS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CMS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
S1PR1_HUMAN	S1PR1	physical	21988832
GLYG_HUMAN	GYG1	physical	21988832
PCDH7_HUMAN	PCDH7	physical	26186194
PSME3_HUMAN	PSME3	physical	26186194
MRGBP_HUMAN	MRGBP	physical	26186194
MDM2_HUMAN	MDM2	physical	26186194
PCDH7_HUMAN	PCDH7	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.