GLYG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLYG_HUMAN
• UniProt AC: P46976
• Protein Name: Glycogenin-1
• Gene Name: GYG1
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Protein Description: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase..
• Protein Sequence: MTDQAFVTLTTNDAYAKGALVLGSSLKQHRTTRRLVVLATPQVSDSMRKVLETVFDEVIMVDVLDSGDSAHLTLMKRPELGVTLTKLHCWSLTQYSKCVFMDADTLVLANIDDLFDREELSAAPDPGWPDCFNSGVFVYQPSVETYNQLLHLASEQGSFDGGDQGILNTFFSSWATTDIRKHLPFIYNLSSISIYSYLPAFKVFGASAKVVHFLGRVKPWNYTYDPKTKSVKSEAHDPNMTHPEFLILWWNIFTTNVLPLLQQFGLVKDTCSYVNVLSDLVYTLAFSCGFCRKEDVSGAISHLSLGEIPAMAQPFVSSEERKERWEQGQADYMGADSFDNIKRKLDTYLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDQAFVTL ------CCCCEEEEE	36.50	22673903
2	Acetylation	------MTDQAFVTL ------CCCCEEEEE	36.50	22223895
8	Phosphorylation	MTDQAFVTLTTNDAY CCCCEEEEEECCCHH	16.37	22673903
10	Phosphorylation	DQAFVTLTTNDAYAK CCEEEEEECCCHHHC	17.75	22673903
11	Phosphorylation	QAFVTLTTNDAYAKG CEEEEEECCCHHHCC	33.93	22673903
15	Phosphorylation	TLTTNDAYAKGALVL EEECCCHHHCCCEEE	16.23	22673903
24	Phosphorylation	KGALVLGSSLKQHRT CCCEEECHHHHHCCC	28.47	21406692
25	Phosphorylation	GALVLGSSLKQHRTT CCEEECHHHHHCCCC	37.47	24719451
27	Ubiquitination	LVLGSSLKQHRTTRR EEECHHHHHCCCCCE	46.11	30230243
44	Phosphorylation	VLATPQVSDSMRKVL EEECHHCCHHHHHHH	20.79	20068231
46	Phosphorylation	ATPQVSDSMRKVLET ECHHCCHHHHHHHHH	17.00	26437602
55	Ubiquitination	RKVLETVFDEVIMVD HHHHHHHCCEEEEEE	9.65	21890473
150	Ubiquitination	VETYNQLLHLASEQG HHHHHHHHHHHHHCC	1.93	21890473
173	Ubiquitination	ILNTFFSSWATTDIR HHHHHHHHHCCCHHH	18.64	24816145
195	O-linked_Glycosylation	NLSSISIYSYLPAFK ECCCCCHHHHCHHHH	5.62	22160680
196	Phosphorylation	LSSISIYSYLPAFKV CCCCCHHHHCHHHHH	20.65	-
197	Phosphorylation	SSISIYSYLPAFKVF CCCCHHHHCHHHHHH	10.34	-
209 (in isoform 1)	Ubiquitination	-	42.15	21890473
209 (in isoform 2)	Ubiquitination	-	42.15	21890473
209	Ubiquitination	KVFGASAKVVHFLGR HHHCCEEEEEHHHCC	42.15	22817900
218	Ubiquitination	VHFLGRVKPWNYTYD EHHHCCCCCCCCCCC	42.85	30230243
222	Phosphorylation	GRVKPWNYTYDPKTK CCCCCCCCCCCCCCC	11.65	25278378
223	Phosphorylation	RVKPWNYTYDPKTKS CCCCCCCCCCCCCCC	20.45	25278378
224	Phosphorylation	VKPWNYTYDPKTKSV CCCCCCCCCCCCCCC	21.64	25278378
226 (in isoform 3)	Phosphorylation	-	35.48	-
228	Phosphorylation	NYTYDPKTKSVKSEA CCCCCCCCCCCCCCC	33.66	25278378
230	Phosphorylation	TYDPKTKSVKSEAHD CCCCCCCCCCCCCCC	39.75	25278378
233	Phosphorylation	PKTKSVKSEAHDPNM CCCCCCCCCCCCCCC	37.55	-
254	Phosphorylation	ILWWNIFTTNVLPLL HHHHHHHHHCHHHHH	17.42	-
255	Phosphorylation	LWWNIFTTNVLPLLQ HHHHHHHHCHHHHHH	16.75	-
268	Ubiquitination	LQQFGLVKDTCSYVN HHHHCCCHHHHHHHH	52.98	24816145
273 (in isoform 2)	Phosphorylation	-	9.74	-
287 (in isoform 2)	Phosphorylation	-	14.02	27251275
297	Phosphorylation	FCRKEDVSGAISHLS CCCCCCCCHHHHHCC	34.52	-
300 (in isoform 2)	Phosphorylation	-	2.80	28348404
301 (in isoform 2)	Phosphorylation	-	20.17	28348404
304	Phosphorylation	SGAISHLSLGEIPAM CHHHHHCCCCCCCHH	28.98	-
317	Phosphorylation	AMAQPFVSSEERKER HHHCCCCCHHHHHHH	32.20	25627689
318	Phosphorylation	MAQPFVSSEERKERW HHCCCCCHHHHHHHH	37.87	25627689
327	Ubiquitination	ERKERWEQGQADYMG HHHHHHHHHCCCCCC	42.19	24816145
332	Phosphorylation	WEQGQADYMGADSFD HHHHCCCCCCCCCHH	10.64	28796482
333	Sulfoxidation	EQGQADYMGADSFDN HHHCCCCCCCCCHHH	3.52	30846556
337	Phosphorylation	ADYMGADSFDNIKRK CCCCCCCCHHHHHHH	33.68	28857561
342	2-Hydroxyisobutyrylation	ADSFDNIKRKLDTYL CCCHHHHHHHHHHHC	50.13	-
344	Ubiquitination	SFDNIKRKLDTYLQ- CHHHHHHHHHHHCC-	45.79	24816145
347	Phosphorylation	NIKRKLDTYLQ---- HHHHHHHHHCC----	36.25	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLYG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLYG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLYG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GYS1_HUMAN	GYS1	physical	16189514
P121A_HUMAN	POM121	physical	16189514
TRIM7_HUMAN	TRIM7	physical	11916970
GLYG2_HUMAN	GYG2	physical	9857012
TRIM7_HUMAN	TRIM7	physical	14984203
GYS1_HUMAN	GYS1	physical	25416956
ESTD_HUMAN	ESD	physical	26344197
GGT1_HUMAN	GGT1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613507: Glycogen storage disease 15 (GSD15)
• 616199: Polyglucosan body myopathy 2 (PGBM2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.