TEN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEN4_HUMAN
• UniProt AC: Q6N022
• Protein Name: Teneurin-4
• Gene Name: TENM4
• Organism: Homo sapiens (Human).
• Sequence Length: 2769
• Subcellular Localization: Cell membrane ; Single-pass membrane protein . Cell projection . Nucleus . Cytoplasm .
• Protein Description: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). [PubMed: 26188006 Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity]
• Protein Sequence: MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRVKDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPPPPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWLLNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYFVAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGTTEGKPSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYGRKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWHLAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVLCSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEVDCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWTGHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPGWNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGDSKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKFLVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSFDLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPNPVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLTHPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGYEYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQPPVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEVVAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIISTLLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRIVAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTSGEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFRSLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKAYNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISNSQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSILGVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVTTDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRTLENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMRQSEMGRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	RRDAERRYTSSSADS HHHHHHHHCCCCCCC	19.73	27732954
23	Phosphorylation	RDAERRYTSSSADSE HHHHHHHCCCCCCCC	21.96	27732954
24	Phosphorylation	DAERRYTSSSADSEE HHHHHHCCCCCCCCC	17.23	27732954
25	Phosphorylation	AERRYTSSSADSEEG HHHHHCCCCCCCCCC	23.03	27732954
26	Phosphorylation	ERRYTSSSADSEEGK HHHHCCCCCCCCCCC	35.54	27732954
29	Phosphorylation	YTSSSADSEEGKAPQ HCCCCCCCCCCCCCC	36.95	27732954
38	Phosphorylation	EGKAPQKSYSSSETL CCCCCCCCCCCHHHH	25.62	30631047
39	Phosphorylation	GKAPQKSYSSSETLK CCCCCCCCCCHHHHH	21.43	25884760
41	Phosphorylation	APQKSYSSSETLKAY CCCCCCCCHHHHHHH	24.78	22985185
42	Phosphorylation	PQKSYSSSETLKAYD CCCCCCCHHHHHHHC	28.76	30631047
44	Phosphorylation	KSYSSSETLKAYDQD CCCCCHHHHHHHCHH	35.19	30631047
74	Phosphorylation	EAEEFCRTGANFTLR HHHHHHHHCCCEEHH	41.65	22210691
79	Phosphorylation	CRTGANFTLRELGLE HHHCCCEEHHHCCCC	25.39	24719451
89	Phosphorylation	ELGLEEVTPPHGTLY HCCCCCCCCCCCCEE	34.09	22199227
96	Phosphorylation	TPPHGTLYRTDIGLP CCCCCCEEECCCCCC	16.00	27732954
98	Phosphorylation	PHGTLYRTDIGLPHC CCCCEEECCCCCCCC	20.57	27732954
107	Phosphorylation	IGLPHCGYSMGAGSD CCCCCCCCCCCCCCC	10.81	27732954
108	Phosphorylation	GLPHCGYSMGAGSDA CCCCCCCCCCCCCCC	8.95	27732954
113	Phosphorylation	GYSMGAGSDADMEAD CCCCCCCCCCCCCCC	29.14	27732954
121	Phosphorylation	DADMEADTVLSPEHP CCCCCCCCCCCCCCC	30.32	27732954
124	Phosphorylation	MEADTVLSPEHPVRL CCCCCCCCCCCCCCC	24.73	-
135	Phosphorylation	PVRLWGRSTRSGRSS CCCCCCCCCCCCCHH	25.00	22210691
138	O-linked_Glycosylation	LWGRSTRSGRSSCLS CCCCCCCCCCHHHCC	38.35	30379171
150	Phosphorylation	CLSSRANSNLTLTDT HCCCCCCCCCEECCC	32.03	24719451
153	Phosphorylation	SRANSNLTLTDTEHE CCCCCCCEECCCCCC	31.68	25921289
155	Phosphorylation	ANSNLTLTDTEHENT CCCCCEECCCCCCCC	35.32	25921289
178	Phosphorylation	QNHARLRTPPPPLSH CCCCCCCCCCCCCCC	44.75	20363803
184	Phosphorylation	RTPPPPLSHAHTPNQ CCCCCCCCCCCCCCC	25.13	27732954
188	Phosphorylation	PPLSHAHTPNQHHAA CCCCCCCCCCCCCCC	25.39	27732954
196	Phosphorylation	PNQHHAASINSLNRG CCCCCCCCCCCCCCC	24.08	20363803
199	Phosphorylation	HHAASINSLNRGNFT CCCCCCCCCCCCCCC	25.92	20363803
206	Phosphorylation	SLNRGNFTPRSNPSP CCCCCCCCCCCCCCC	23.07	24719451
209	Phosphorylation	RGNFTPRSNPSPAPT CCCCCCCCCCCCCCC	55.05	25921289
212	Phosphorylation	FTPRSNPSPAPTDHS CCCCCCCCCCCCCCC	37.63	25921289
216	Phosphorylation	SNPSPAPTDHSLSGE CCCCCCCCCCCCCCC	48.74	25921289
219	Phosphorylation	SPAPTDHSLSGEPPA CCCCCCCCCCCCCCC	27.34	25921289
281	Phosphorylation	SRHDGAYSDGHFLFK CCCCCCCCCCEEEEC	36.26	-
312	Phosphorylation	LTSSTVYSPPPRPLP CCCCCCCCCCCCCCC	26.96	26329039
394	O-linked_Glycosylation	ASSWPVPTDVSLYPS CCCCCCCCEEEEECC	49.63	OGP
399	Phosphorylation	VPTDVSLYPSGGTGL CCCEEEEECCCCCCC	6.45	-
467	N-linked_Glycosylation	HPVHLKFNVSLGKAA CCEEEEEEEECCCCC	22.38	UniProtKB CARBOHYD
596	Phosphorylation	GPDCGRASCPVLCSG CCCCCCCCCCEEECC	20.00	-
602	Phosphorylation	ASCPVLCSGNGQYMK CCCCEEECCCCCEEC	31.00	-
607	Phosphorylation	LCSGNGQYMKGRCLC EECCCCCEECCEEEE	11.37	-
656	Phosphorylation	NPGYKGESCEEVDCM CCCCCCCCCCEECCC	35.18	-
666	Phosphorylation	EVDCMDPTCSGRGVC EECCCCCCCCCCCEE	18.29	-
668	Phosphorylation	DCMDPTCSGRGVCVR CCCCCCCCCCCEEEC	33.72	-
832	Phosphorylation	WRGAGCDTSMETACG CCCCCCCCCCCCCCC	33.77	-
833	Phosphorylation	RGAGCDTSMETACGD CCCCCCCCCCCCCCC	11.02	-
940	N-linked_Glycosylation	GTPLVGVNISFVNNP CCEEEEEEEEECCCC	20.47	UniProtKB CARBOHYD
1062	Phosphorylation	SGCKMRLSYLSSRTP CCCHHHHHHHHCCCC	17.42	21955146
1063	Phosphorylation	GCKMRLSYLSSRTPG CCHHHHHHHHCCCCC	18.39	21955146
1065	Phosphorylation	KMRLSYLSSRTPGYK HHHHHHHHCCCCCCC	15.00	21955146
1066	Phosphorylation	MRLSYLSSRTPGYKS HHHHHHHCCCCCCCE	37.26	21955146
1068	Phosphorylation	LSYLSSRTPGYKSVL HHHHHCCCCCCCEEE	24.02	21955146
1071	Phosphorylation	LSSRTPGYKSVLRIS HHCCCCCCCEEEEEE	10.99	21955146
1197	Phosphorylation	NGENQFVSQQPPVIG CCCCCCCCCCCCEEE	25.12	26074081
1205	Phosphorylation	QQPPVIGSIMGNGRR CCCCEEEEECCCCCC	9.77	26074081
1259	N-linked_Glycosylation	RRIFPSGNVTNILEL EEECCCCCEEEEEEE	41.60	UniProtKB CARBOHYD
1367	Phosphorylation	LIYFVDGTMIRRIDQ EEEEECCCEEEEECC	12.64	-
1471	Phosphorylation	HATLESATALAVSHN HHHHHHHHEEEEECC	31.33	-
1476	Phosphorylation	SATALAVSHNGVLYI HHHEEEEECCCEEEE	12.96	-
1525	Phosphorylation	DANCDCFSGDDGYAK CCCCCCCCCCCCCCC	47.87	-
1530	Phosphorylation	CFSGDDGYAKDAKLN CCCCCCCCCCCCCCC	19.92	-
1576	Phosphorylation	FLNTQNMYELSSPID CCCCCCCEECCCCCC	22.67	-
1609	N-linked_Glycosylation	PTGDYLYNFTYTGDG CCCCEEEEEEEECCC	21.86	UniProtKB CARBOHYD
1693	Phosphorylation	SNENGWTTFYEYDSF CCCCCCEEEEEECCC	20.08	-
1697	Phosphorylation	GWTTFYEYDSFGRLT CCEEEEEECCCCCEE	12.90	-
1699	Phosphorylation	TTFYEYDSFGRLTNV EEEEEECCCCCEEEE	28.79	-
1705	N-linked_Glycosylation	DSFGRLTNVTFPTGQ CCCCCEEEEEECCCC	35.11	UniProtKB CARBOHYD
1714	Phosphorylation	TFPTGQVSSFRSDTD EECCCCCEEEECCCC	18.83	22817900
1718	Phosphorylation	GQVSSFRSDTDSSVH CCCEEEECCCCCCEE	42.74	30576142
1722	Phosphorylation	SFRSDTDSSVHVQVE EEECCCCCCEEEEEE	36.03	30576142
1732	Phosphorylation	HVQVETSSKDDVTIT EEEEEECCCCCEEEE	47.74	30576142
1741	N-linked_Glycosylation	DDVTITTNLSASGAF CCEEEEEEECCCCHH	24.29	UniProtKB CARBOHYD
1799	N-linked_Glycosylation	NPTVGKRNVTLPIDN CCCCCCCEEEEECCC	34.31	UniProtKB CARBOHYD
1825	Phosphorylation	EQARGQVTVFGRRLR HHHCCCEEEECEEEE	11.39	27134283
1860	Phosphorylation	YDDHRKFTLRILYDQ CCCCCCEEEEHEECC	20.40	24719451
1884	N-linked_Glycosylation	SSRLNGVNVTYSPGG CCCCCCEEEEECCCC	23.08	UniProtKB CARBOHYD
1886	Phosphorylation	RLNGVNVTYSPGGYI CCCCEEEEECCCCHH	17.06	28857561
1888	Phosphorylation	NGVNVTYSPGGYIAG CCEEEEECCCCHHHH	14.01	21712546
1892	Phosphorylation	VTYSPGGYIAGIQRG EEECCCCHHHHHCCC	8.10	21712546
1902	Phosphorylation	GIQRGIMSERMEYDQ HHCCCHHHCCCCCCC	21.82	24719451
1914	Phosphorylation	YDQAGRITSRIFADG CCCCCCCEEEEECCC	15.59	22210691
1923	Phosphorylation	RIFADGKTWSYTYLE EEECCCCEEEEEEHH	25.77	25954137
1926	Phosphorylation	ADGKTWSYTYLEKSM CCCCEEEEEEHHHHH	7.32	25954137
1927	Phosphorylation	DGKTWSYTYLEKSMV CCCEEEEEEHHHHHH	19.00	22210691
1928	Phosphorylation	GKTWSYTYLEKSMVL CCEEEEEEHHHHHHE	12.48	-
1985	N-linked_Glycosylation	IYQPPEGNASVIQDF EECCCCCCCCCEEEE	27.64	UniProtKB CARBOHYD
2012	Phosphorylation	GTGRRVIYKYGKLSK CCCCEEHHHCCHHHH	8.70	29083192
2014	Phosphorylation	GRRVIYKYGKLSKLA CCEEHHHCCHHHHHH	11.52	29083192
2018	Phosphorylation	IYKYGKLSKLAETLY HHHCCHHHHHHHHHH	29.16	29083192
2031	Phosphorylation	LYDTTKVSFTYDETA HHHCCEEEEEEECCC	17.27	25404012
2033	Phosphorylation	DTTKVSFTYDETAGM HCCEEEEEEECCCCE	23.66	25404012
2034	Phosphorylation	TTKVSFTYDETAGML CCEEEEEEECCCCEE	15.12	25404012
2037	Phosphorylation	VSFTYDETAGMLKTI EEEEEECCCCEEEEE	26.13	25404012
2156	Phosphorylation	GRMKEVQYEIFRSLM CCHHHHHHHHHHHHH	19.03	-
2161	Phosphorylation	VQYEIFRSLMYWMTV HHHHHHHHHHHHHHC	13.51	23663014
2164	Phosphorylation	EIFRSLMYWMTVQYD HHHHHHHHHHHCCCC	9.42	23663014
2167	Phosphorylation	RSLMYWMTVQYDNMG HHHHHHHHCCCCCCC	7.13	23663014
2170	Phosphorylation	MYWMTVQYDNMGRVV HHHHHCCCCCCCCEE	12.63	23663014
2186	Phosphorylation	KELKVGPYANTTRYS EEEECCCCCCCCEEE	13.42	-
2188	N-linked_Glycosylation	LKVGPYANTTRYSYE EECCCCCCCCEEEEE	35.82	UniProtKB CARBOHYD
2235	Phosphorylation	PGNSARLTPLRYDIR CCCCCCCCCCCCCHH	18.09	24719451
2239	Phosphorylation	ARLTPLRYDIRDRIT CCCCCCCCCHHHHHH	24.33	24719451
2328	N-linked_Glycosylation	TKVTHLYNHSSSEIT CEEEEEECCCCCCCH	34.62	UniProtKB CARBOHYD
2568	Ubiquitination	SSGSVFGKGVKFALK CCCCCCCCCEEEEEC	49.41	-
2571	Ubiquitination	SVFGKGVKFALKDGR CCCCCCEEEEECCCC	33.32	-
2575	Ubiquitination	KGVKFALKDGRVTTD CCEEEEECCCCEEEE	55.49	-
2580	Phosphorylation	ALKDGRVTTDIISVA EECCCCEEEEEEEEE	19.86	25627689
2581	Phosphorylation	LKDGRVTTDIISVAN ECCCCEEEEEEEEEC	23.50	25627689
2585	Phosphorylation	RVTTDIISVANEDGR CEEEEEEEEECCCHH	18.60	25627689
2646	N-linked_Glycosylation	RTLENGVNVTVSQIN CCCCCCCEEEHHHHH	25.74	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TEN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.