ZN140_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN140_HUMAN
• UniProt AC: P52738
• Protein Name: Zinc finger protein 140
• Gene Name: ZNF140
• Organism: Homo sapiens (Human).
• Sequence Length: 457
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation as a repressor..
• Protein Sequence: MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVSLGLSISKPDVVSLLEQGKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYLIMERILSQGPVYSSFKGGWKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPYGCHECGKTFGRRFSLVLHQRTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHTGEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKPYECIECGKAFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECDECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNKSFSWSSNLAKHQRTHTLDNPYEYENSFNYHSFLTEHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	RCVMLENYGHLVSLG HHHHHHCCCEEEEEE	9.13	25072903
44	Phosphorylation	ENYGHLVSLGLSISK HCCCEEEEEECCCCC	24.07	25072903
48	Phosphorylation	HLVSLGLSISKPDVV EEEEEECCCCCCCHH	24.02	25072903
50	Phosphorylation	VSLGLSISKPDVVSL EEEECCCCCCCHHHH	34.46	25072903
89	Phosphorylation	SGEIKDFSPKNVIYD CCCCCCCCCCCEECC	45.13	24719451
98	Phosphorylation	KNVIYDDSSQYLIME CCEECCCHHHHHHHH	19.22	21299198
99	Phosphorylation	NVIYDDSSQYLIMER CEECCCHHHHHHHHH	29.82	21299198
114	Phosphorylation	ILSQGPVYSSFKGGW HHHCCCCCCCCCCCE	11.17	27642862
175	Phosphorylation	KTFGRRFSLVLHQRT CCCCCEEEEEEEECC	18.76	30108239
182	Phosphorylation	SLVLHQRTHTGEKPY EEEEEECCCCCCCCE	19.74	-
184	Phosphorylation	VLHQRTHTGEKPYAC EEEECCCCCCCCEEH	46.56	-
187	Ubiquitination	QRTHTGEKPYACKEC ECCCCCCCCEEHHHH	44.68	-
197	Phosphorylation	ACKECGKTFSQISNL EHHHHCCCHHHHHHH	17.50	30206219
199	Phosphorylation	KECGKTFSQISNLVK HHHCCCHHHHHHHHH	31.66	30206219
202	Phosphorylation	GKTFSQISNLVKHQM CCCHHHHHHHHHHHH	19.24	30206219
212	Phosphorylation	VKHQMIHTGKKPHEC HHHHHHCCCCCCCCC	39.51	30206219
214	Acetylation	HQMIHTGKKPHECKD HHHHCCCCCCCCCCC	65.37	7987759
238	Phosphorylation	FLIEHQRTHTGEKPY HHHHCCCCCCCCCCE	19.74	-
240	Phosphorylation	IEHQRTHTGEKPYEC HHCCCCCCCCCCEEE	46.56	-
252	Acetylation	YECTECGKAFSRASN EEECHHHHHHHHHHC	58.90	7934185
376	Phosphorylation	HASLIQHTKSHTGEK EHHHHHHHHCCCCCC	20.19	25332170
397	Phosphorylation	CDKAFSRSFSLILHQ CHHHHHHCCEEEEEE	20.28	28555341
399	Phosphorylation	KAFSRSFSLILHQRT HHHHHCCEEEEEECC	18.75	23186163
406	Phosphorylation	SLILHQRTHTGEKPY EEEEEECCCCCCCCE	19.74	-
408	Phosphorylation	ILHQRTHTGEKPYVC EEEECCCCCCCCEEE	46.56	-
411	Sumoylation	QRTHTGEKPYVCKVC ECCCCCCCCEEEEEC	42.89	-
411	Sumoylation	QRTHTGEKPYVCKVC ECCCCCCCCEEEEEC	42.89	-
423	Phosphorylation	KVCNKSFSWSSNLAK EECCCCCCCCCCHHH	32.89	-
425	Phosphorylation	CNKSFSWSSNLAKHQ CCCCCCCCCCHHHCC	14.24	-
426	Phosphorylation	NKSFSWSSNLAKHQR CCCCCCCCCHHHCCC	29.60	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN140_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN140_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN140_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	8769649

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.