TSAP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSAP1_HUMAN
• UniProt AC: Q9NX07
• Protein Name: tRNA selenocysteine 1-associated protein 1
• Gene Name: TRNAU1AP
• Organism: Homo sapiens (Human).
• Sequence Length: 287
• Subcellular Localization: Nucleus. Cytoplasm. Abundant in the nucleus..
• Protein Description: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity)..
• Protein Sequence: MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIPAGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGDLTPDVDDGMLYEFFVKVYPSCRGGKVVLDQTGVSKGYGFVKFTDELEQKRALTECQGAVGLGSKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSYSYPQYGYTQSTMQTYEEVGDDALEDPMPQLDVTEANKEFMEQSEELYDALMDCHWQPLDTVSSEIPAMM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17 (in isoform 2)	Ubiquitination	-	34.98	21906983
17	Ubiquitination	LEPYMDENFISRAFA CHHHCCHHHHHHHHH	34.98	22817900
32	Phosphorylation	TMGETVMSVKIIRNR HCCCCHHHHHHHHHC	18.87	24719451
41 (in isoform 2)	Ubiquitination	-	29.81	21906983
41	Ubiquitination	KIIRNRLTGIPAGYC HHHHHCCCCCCCCEE	29.81	22817900
56	Ubiquitination	FVEFADLATAEKCLH EEEHHHHHHHHHHHH	12.81	24816145
64	Ubiquitination	TAEKCLHKINGKPLP HHHHHHHHHCCEECC	25.56	29967540
66	Ubiquitination	EKCLHKINGKPLPGA HHHHHHHCCEECCCC	58.18	27667366
68	Ubiquitination	CLHKINGKPLPGATP HHHHHCCEECCCCCC	38.60	27667366
74	Phosphorylation	GKPLPGATPAKRFKL CEECCCCCCCCEEEE	29.69	26055452
77	Ubiquitination	LPGATPAKRFKLNYA CCCCCCCCEEEEEEE	60.62	27667366
80	Ubiquitination	ATPAKRFKLNYATYG CCCCCEEEEEEECCC	39.60	-
83	Phosphorylation	AKRFKLNYATYGKQP CCEEEEEEECCCCCC	15.68	28787133
86	Phosphorylation	FKLNYATYGKQPDNS EEEEEECCCCCCCCC	17.72	28787133
96	Phosphorylation	QPDNSPEYSLFVGDL CCCCCCCEEEEEEEC	17.66	28787133
122	Phosphorylation	FFVKVYPSCRGGKVV EEEEECCCCCCCEEE	9.96	30631047
124	Methylation	VKVYPSCRGGKVVLD EEECCCCCCCEEEEC	62.33	115919041
127	Ubiquitination	YPSCRGGKVVLDQTG CCCCCCCEEEECCCC	31.81	21906983
127 (in isoform 1)	Ubiquitination	-	31.81	21906983
137	Ubiquitination	LDQTGVSKGYGFVKF ECCCCCCCCCCEEEE	54.46	29967540
143	Ubiquitination	SKGYGFVKFTDELEQ CCCCCEEEECHHHHH	40.04	29967540
151	Ubiquitination	FTDELEQKRALTECQ ECHHHHHHHHHHHCC	30.20	22817900
151 (in isoform 1)	Ubiquitination	-	30.20	21906983
165	Phosphorylation	QGAVGLGSKPVRLSV CCCCCCCCCCEEEEE	38.54	22210691
166	Ubiquitination	GAVGLGSKPVRLSVA CCCCCCCCCEEEEEE	45.81	24816145
176	Ubiquitination	RLSVAIPKASRVKPV EEEEEECCCCCCCCC	53.53	27667366
261	Phosphorylation	NKEFMEQSEELYDAL HHHHHHHHHHHHHHH	21.52	25072903
265	Phosphorylation	MEQSEELYDALMDCH HHHHHHHHHHHHHCC	11.49	25072903
278	Phosphorylation	CHWQPLDTVSSEIPA CCCCCCCCCCCCCCC	29.94	25072903
280	Phosphorylation	WQPLDTVSSEIPAMM CCCCCCCCCCCCCCC	25.09	25072903
281	Phosphorylation	QPLDTVSSEIPAMM- CCCCCCCCCCCCCC-	34.90	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSAP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSAP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSAP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMNB2_HUMAN	LMNB2	physical	26186194
PRP39_HUMAN	PRPF39	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
PRP39_HUMAN	PRPF39	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.