TMA16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMA16_HUMAN
• UniProt AC: Q96EY4
• Protein Name: Translation machinery-associated protein 16
• Gene Name: TMA16
• Organism: Homo sapiens (Human).
• Sequence Length: 203
• Protein Sequence: MPKAPKGKSAGREKKVIHPYSRKAAQITREAHKQEKKEKLKNEKALRLNLVGEKLQWFQNHLDPQKKRYSKKDACELIERYLNRFSSELEQIELHNSIRDRQGRRHCSRETVIKQTMERERQQFEGYGLEIPDILNASNLKTFREWDFDLKKLPNIKMRKICANDAIPKTCKRKTIITVDQDLGELELNDESSDSDEEMTAVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MPKAPKGKSAGREKK CCCCCCCCCCCCCCC	43.17	24816145
9	ADP-ribosylation	PKAPKGKSAGREKKV CCCCCCCCCCCCCCC	44.62	28190768
9	Phosphorylation	PKAPKGKSAGREKKV CCCCCCCCCCCCCCC	44.62	29449344
15	Sumoylation	KSAGREKKVIHPYSR CCCCCCCCCCCCHHH	41.49	-
15	Sumoylation	KSAGREKKVIHPYSR CCCCCCCCCCCCHHH	41.49	-
23	Ubiquitination	VIHPYSRKAAQITRE CCCCHHHHHHHHHHH	41.98	29967540
37	Ubiquitination	EAHKQEKKEKLKNEK HHHHHHHHHHHHCHH	60.37	-
41	Ubiquitination	QEKKEKLKNEKALRL HHHHHHHHCHHHHHH	74.30	-
44	Ubiquitination	KEKLKNEKALRLNLV HHHHHCHHHHHHHHH	63.21	24816145
44	Acetylation	KEKLKNEKALRLNLV HHHHHCHHHHHHHHH	63.21	25953088
71	Ubiquitination	PQKKRYSKKDACELI HHHHCCCHHHHHHHH	45.82	24816145
86	Phosphorylation	ERYLNRFSSELEQIE HHHHHHHCHHHHHHH	21.48	28348404
87	Phosphorylation	RYLNRFSSELEQIEL HHHHHHCHHHHHHHH	43.41	28122231
97	Phosphorylation	EQIELHNSIRDRQGR HHHHHHHHHHHHHCC	14.30	24117733
114	Acetylation	CSRETVIKQTMERER CCHHHHHHHHHHHHH	35.07	27452117
114	Ubiquitination	CSRETVIKQTMERER CCHHHHHHHHHHHHH	35.07	24816145
127	Phosphorylation	ERQQFEGYGLEIPDI HHHHHCCCCCCHHHH	16.02	20068231
138	Phosphorylation	IPDILNASNLKTFRE HHHHCCHHCCCCHHH	41.44	25159151
142	Phosphorylation	LNASNLKTFREWDFD CCHHCCCCHHHCCCC	30.96	20068231
160	Ubiquitination	LPNIKMRKICANDAI CCCCCCHHHCCCCCC	38.34	24816145
170	Phosphorylation	ANDAIPKTCKRKTII CCCCCCCCCCCCEEE	20.22	-
175	Phosphorylation	PKTCKRKTIITVDQD CCCCCCCEEEEECCC	22.96	-
178	Phosphorylation	CKRKTIITVDQDLGE CCCCEEEEECCCCCC	17.74	29514088
192	Phosphorylation	ELELNDESSDSDEEM CEECCCCCCCCHHHH	42.16	29514088
193	Phosphorylation	LELNDESSDSDEEMT EECCCCCCCCHHHHH	38.80	29514088
195	Phosphorylation	LNDESSDSDEEMTAV CCCCCCCCHHHHHHC	49.20	29514088
200	Phosphorylation	SDSDEEMTAVA---- CCCHHHHHHCC----	22.66	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMA16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMA16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMA16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KR107_HUMAN	KRTAP10-7	physical	25416956
PHF3_HUMAN	PHF3	physical	28514442
TNPO2_HUMAN	TNPO2	physical	28514442
RBM12_HUMAN	RBM12	physical	28514442
NHRF2_HUMAN	SLC9A3R2	physical	28514442
PYGB_HUMAN	PYGB	physical	28514442
PPID_HUMAN	PPID	physical	28514442
CENPF_HUMAN	CENPF	physical	28514442
KLH20_HUMAN	KLHL20	physical	28514442
TNPO1_HUMAN	TNPO1	physical	28514442
SPT4H_HUMAN	SUPT4H1	physical	28514442
SC24D_HUMAN	SEC24D	physical	28514442
PPIL4_HUMAN	PPIL4	physical	28514442
RABL6_HUMAN	RABL6	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
GOGA3_HUMAN	GOLGA3	physical	28514442
SPT6H_HUMAN	SUPT6H	physical	28514442
EEA1_HUMAN	EEA1	physical	28514442
PRC2A_HUMAN	PRRC2A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.