MCES_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCES_HUMAN
• UniProt AC: O43148
• Protein Name: mRNA cap guanine-N7 methyltransferase
• Gene Name: RNMT
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Nucleus .
• Protein Description: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. [PubMed: 9790902]
• Protein Sequence: MANSAKAEEYEKMSLEQAKASVNSETESSFNINENTTASGTGLSEKTSVCRQVDIARKRKEFEDDLVKESSSCGKDTPSKKRKLDPEIVPEEKDCGDAEGNSKKRKRETEDVPKDKSSTGDGTQNKRKIALEDVPEKQKNLEEGHSSTVAAHYNELQEVGLEKRSQSRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSIYLVFAFEKQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MANSAKAEEYEKM --CCCCHHHHHHHHC	57.03	23749302
10	Phosphorylation	NSAKAEEYEKMSLEQ CCHHHHHHHHCCHHH	16.62	-
14	Phosphorylation	AEEYEKMSLEQAKAS HHHHHHCCHHHHHHH	39.56	27134283
21	Phosphorylation	SLEQAKASVNSETES CHHHHHHHCCCCCCC	22.56	28450419
24	Phosphorylation	QAKASVNSETESSFN HHHHHCCCCCCCCEE	43.68	28450419
26	Phosphorylation	KASVNSETESSFNIN HHHCCCCCCCCEECC	40.77	28450419
28	Phosphorylation	SVNSETESSFNINEN HCCCCCCCCEECCCC	47.88	27251275
29	Phosphorylation	VNSETESSFNINENT CCCCCCCCEECCCCC	18.97	28450419
39	Phosphorylation	INENTTASGTGLSEK CCCCCCCCCCCCCCC	34.49	27251275
44	Phosphorylation	TASGTGLSEKTSVCR CCCCCCCCCCCCHHH	38.09	-
70	Phosphorylation	EDDLVKESSSCGKDT HHHHHHHHHCCCCCC	23.10	26552605
71	Phosphorylation	DDLVKESSSCGKDTP HHHHHHHHCCCCCCC	30.64	26552605
72	Phosphorylation	DLVKESSSCGKDTPS HHHHHHHCCCCCCCC	35.85	25849741
75	Acetylation	KESSSCGKDTPSKKR HHHHCCCCCCCCCCC	63.86	26051181
77	Phosphorylation	SSSCGKDTPSKKRKL HHCCCCCCCCCCCCC	32.71	23401153
79	Phosphorylation	SCGKDTPSKKRKLDP CCCCCCCCCCCCCCC	53.56	28985074
93	Acetylation	PEIVPEEKDCGDAEG CCCCCCCCCCCCCCC	57.57	25953088
118	Phosphorylation	DVPKDKSSTGDGTQN CCCCCCCCCCCCCCC	41.99	-
126	Acetylation	TGDGTQNKRKIALED CCCCCCCCEEEEHHH	45.29	20167786
128	Acetylation	DGTQNKRKIALEDVP CCCCCCEEEEHHHCC	33.66	20167786
128	Ubiquitination	DGTQNKRKIALEDVP CCCCCCEEEEHHHCC	33.66	-
137	Acetylation	ALEDVPEKQKNLEEG EHHHCCHHHHCHHCC	61.58	20167786
137	Malonylation	ALEDVPEKQKNLEEG EHHHCCHHHHCHHCC	61.58	26320211
137	Ubiquitination	ALEDVPEKQKNLEEG EHHHCCHHHHCHHCC	61.58	-
139	Ubiquitination	EDVPEKQKNLEEGHS HHCCHHHHCHHCCCH	74.66	-
148	Phosphorylation	LEEGHSSTVAAHYNE HHCCCHHHHHHHHHH	19.72	28555341
153	Phosphorylation	SSTVAAHYNELQEVG HHHHHHHHHHHHHHC	12.95	28796482
163 (in isoform 1)	Ubiquitination	-	63.49	21906983
163 (in isoform 2)	Ubiquitination	-	63.49	21906983
163	Ubiquitination	LQEVGLEKRSQSRIF HHHHCCCCCCCCCEE	63.49	21906983
165	Phosphorylation	EVGLEKRSQSRIFYL HHCCCCCCCCCEEEE	43.50	23898821
167	Phosphorylation	GLEKRSQSRIFYLRN CCCCCCCCCEEEEEC	28.70	23898821
171	Phosphorylation	RSQSRIFYLRNFNNW CCCCCEEEEECCCHH	11.46	23898821
180	Methylation	RNFNNWMKSVLIGEF ECCCHHHHHHHHHHH	29.09	115976819
181	Phosphorylation	NFNNWMKSVLIGEFL CCCHHHHHHHHHHHH	13.17	20068231
190	Ubiquitination	LIGEFLEKVRQKKKR HHHHHHHHHHHHHCC	44.88	-
190 (in isoform 2)	Ubiquitination	-	44.88	-
208	Ubiquitination	VLDLGCGKGGDLLKW EEECCCCCCHHHHHC	64.89	-
208	Acetylation	VLDLGCGKGGDLLKW EEECCCCCCHHHHHC	64.89	26051181
208 (in isoform 2)	Ubiquitination	-	64.89	-
214	Ubiquitination	GKGGDLLKWKKGRIN CCCHHHHHCCCCCCC	65.35	-
222 (in isoform 2)	Ubiquitination	-	39.67	-
222	Ubiquitination	WKKGRINKLVCTDIA CCCCCCCEEEECHHH	39.67	-
222	Acetylation	WKKGRINKLVCTDIA CCCCCCCEEEECHHH	39.67	25953088
226	Phosphorylation	RINKLVCTDIADVSV CCCEEEECHHHHCCH	23.98	20068231
232	Phosphorylation	CTDIADVSVKQCQQR ECHHHHCCHHHHHHH	24.93	20068231
234 (in isoform 2)	Ubiquitination	-	37.54	-
234	Ubiquitination	DIADVSVKQCQQRYE HHHHCCHHHHHHHHH	37.54	-
309	Phosphorylation	RNACERLSPGGYFIG HHHHHHCCCCCEEEE	27.93	25262027
313	Phosphorylation	ERLSPGGYFIGTTPN HHCCCCCEEEECCCC	9.65	25262027
317	Phosphorylation	PGGYFIGTTPNSFEL CCCEEEECCCCHHHH	33.97	25262027
318	Phosphorylation	GGYFIGTTPNSFELI CCEEEECCCCHHHHH	18.43	25262027
321	Phosphorylation	FIGTTPNSFELIRRL EEECCCCHHHHHHHH	22.69	25262027
331	Phosphorylation	LIRRLEASETESFGN HHHHHHHHHCCCCCC	35.36	-
333	Phosphorylation	RRLEASETESFGNEI HHHHHHHCCCCCCEE	34.14	-
341	Phosphorylation	ESFGNEIYTVKFQKK CCCCCEEEEEEEEEC	10.17	-
385	Phosphorylation	LNEMAKKYNMKLVYK HHHHHHHHCCEEEEH	21.56	-
393	Ubiquitination	NMKLVYKKTFLEFYE CCEEEEHHHHHHHHH	27.16	-
421	Phosphorylation	RMQALEPYPANESSK HHHHCCCCCCCCCCC	12.95	25332170
426	Phosphorylation	EPYPANESSKLVSEK CCCCCCCCCCCHHHH	32.36	25332170
427	Phosphorylation	PYPANESSKLVSEKV CCCCCCCCCCHHHHC	24.67	25332170
428 (in isoform 2)	Ubiquitination	-	63.29	21906983
428 (in isoform 1)	Ubiquitination	-	63.29	21906983
428	Ubiquitination	YPANESSKLVSEKVD CCCCCCCCCHHHHCC	63.29	2190698
433	Acetylation	SSKLVSEKVDDYEHA CCCCHHHHCCCHHHH	43.38	23749302
433	Ubiquitination	SSKLVSEKVDDYEHA CCCCHHHHCCCHHHH	43.38	-
433 (in isoform 2)	Ubiquitination	-	43.38	-
442	Acetylation	DDYEHAAKYMKNSQV CCHHHHHHHHHHCCE	46.81	25953088
442	Ubiquitination	DDYEHAAKYMKNSQV CCHHHHHHHHHHCCE	46.81	-
445 (in isoform 2)	Ubiquitination	-	50.81	-
445	Ubiquitination	EHAAKYMKNSQVRLP HHHHHHHHHCCEEEC	50.81	-
447	Phosphorylation	AAKYMKNSQVRLPLG HHHHHHHCCEEECCC	25.24	21406692
455 (in isoform 2)	Phosphorylation	-	35.23	29888752
455	Phosphorylation	QVRLPLGTLSKSEWE CEEECCCCCCHHHHH	35.23	21406692
457	Phosphorylation	RLPLGTLSKSEWEAT EECCCCCCHHHHHEE	33.69	21406692
457 (in isoform 2)	Phosphorylation	-	33.69	29888752
459 (in isoform 2)	Phosphorylation	-	44.56	29888752
464 (in isoform 2)	Phosphorylation	-	12.25	29888752
467 (in isoform 2)	Phosphorylation	-	9.15	29978859
469 (in isoform 2)	Phosphorylation	-	1.50	29978859
477 (in isoform 2)	Phosphorylation	-		20068231
478 (in isoform 2)	Phosphorylation	-		29978859
489 (in isoform 2)	Phosphorylation	-		20068231
490 (in isoform 2)	Phosphorylation	-		20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCES_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCES_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF23_HUMAN	KIF23	physical	26344197
NF2IP_HUMAN	NFATC2IP	physical	26344197
RAM_HUMAN	FAM103A1	physical	28514442
IMA7_HUMAN	KPNA6	physical	28514442
IMA5_HUMAN	KPNA1	physical	28514442
IMA6_HUMAN	KPNA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.