DCNL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCNL3_HUMAN
• UniProt AC: Q8IWE4
• Protein Name: DCN1-like protein 3
• Gene Name: DCUN1D3
• Organism: Homo sapiens (Human).
• Sequence Length: 304
• Subcellular Localization: Cell membrane .
• Protein Description: Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. [PubMed: 25349211 When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar]
• Protein Sequence: MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQCVTKCK ------CCCCCCCCC	29.60	19617556
4	S-palmitoylation	----MGQCVTKCKNP ----CCCCCCCCCCC	3.30	19617556
8	S-palmitoylation	MGQCVTKCKNPSSTL CCCCCCCCCCCCCCC	3.63	19617556
12	Phosphorylation	VTKCKNPSSTLGSKN CCCCCCCCCCCCCCC	45.40	28102081
13	Phosphorylation	TKCKNPSSTLGSKNG CCCCCCCCCCCCCCC	28.98	28102081
14	Phosphorylation	KCKNPSSTLGSKNGD CCCCCCCCCCCCCCC	39.20	28102081
17	Phosphorylation	NPSSTLGSKNGDREP CCCCCCCCCCCCCCC	26.51	28102081
70	Phosphorylation	TEACQLPTSSGDAGR HHHHCCCCCCCCCCC	44.08	28348404
71	Phosphorylation	EACQLPTSSGDAGRE HHHCCCCCCCCCCCC	30.31	28348404
72	Phosphorylation	ACQLPTSSGDAGRES HHCCCCCCCCCCCCC	43.07	28348404
79	Phosphorylation	SGDAGRESKSNAEES CCCCCCCCCCCHHHH	39.77	28985074
80	Ubiquitination	GDAGRESKSNAEESS CCCCCCCCCCHHHHH	42.87	-
86	Phosphorylation	SKSNAEESSLQRLEE CCCCHHHHHHHHHHH	28.05	23612710
87	Phosphorylation	KSNAEESSLQRLEEL CCCHHHHHHHHHHHH	31.62	23612710
143	Phosphorylation	AATMCKFTRKEFFDG HHHHCCCCHHHHHCC	26.73	-
152	Ubiquitination	KEFFDGCKAISADSI HHHHCCCCEECHHHC	55.04	29967540
155	Phosphorylation	FDGCKAISADSIDGI HCCCCEECHHHCCHH	30.77	19845377
158	Phosphorylation	CKAISADSIDGICAR CCEECHHHCCHHHHH	23.46	28857561
168	Phosphorylation	GICARFPSLLTEAKQ HHHHHCHHHHHHHHH	33.04	30266825
171	Phosphorylation	ARFPSLLTEAKQEDK HHCHHHHHHHHHHHH	38.91	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCNL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCNL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCNL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	23201271
CUL2_HUMAN	CUL2	physical	23201271
CUL3_HUMAN	CUL3	physical	23201271
CUL4A_HUMAN	CUL4A	physical	23201271
CUL4B_HUMAN	CUL4B	physical	23201271
CUL5_HUMAN	CUL5	physical	23201271
CUL1_HUMAN	CUL1	physical	19617556
CUL3_HUMAN	CUL3	physical	19617556
CUL2_HUMAN	CUL2	physical	19617556
CAND1_HUMAN	CAND1	physical	25349211
CUL1_HUMAN	CUL1	physical	25349211
CUL3_HUMAN	CUL3	physical	25349211
RBX1_HUMAN	RBX1	physical	25349211
CUL1_HUMAN	CUL1	physical	26906416
CUL2_HUMAN	CUL2	physical	26906416
CUL3_HUMAN	CUL3	physical	26906416
CUL4A_HUMAN	CUL4A	physical	26906416
CUL4B_HUMAN	CUL4B	physical	26906416
CUL5_HUMAN	CUL5	physical	26906416
CAND1_HUMAN	CAND1	physical	26906416
RBX1_HUMAN	RBX1	physical	26906416
RBX2_HUMAN	RNF7	physical	26906416
ELOB_HUMAN	TCEB2	physical	26906416
UBC12_HUMAN	UBE2M	physical	26906416
CAND1_HUMAN	CAND1	physical	27542266
CUL1_HUMAN	CUL1	physical	27542266

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.