TMC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMC1_HUMAN
• UniProt AC: Q8TDI8
• Protein Name: Transmembrane channel-like protein 1
• Gene Name: TMC1
• Organism: Homo sapiens (Human).
• Sequence Length: 760
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Localized to the stereocilia of the cochlear hair cells.
• Protein Description: Probable ion channel required for the normal function of cochlear hair cells..
• Protein Sequence: MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
337	Phosphorylation	TADNKFNSITMNFKE HCCCHHCCCEECHHH	23.67	27067055
339	Phosphorylation	DNKFNSITMNFKEAI CCHHCCCEECHHHHH	13.09	27067055
347	Phosphorylation	MNFKEAITEEKAAQV ECHHHHHCHHHHHHH	45.18	27067055
480	Phosphorylation	KLVKANITLWEANMI HHHHHCCEEEHHHHH	26.14	23403867
495	Phosphorylation	KAYNASFSENSTGPP HHHHCCCCCCCCCCC	33.11	23403867
498	Phosphorylation	NASFSENSTGPPFFV HCCCCCCCCCCCEEE	30.59	23403867
733	Ubiquitination	ANLDLKKKMKMQALE CCCCHHHHHHHHHHH	42.01	-
747	Ubiquitination	ENKMRNKKMAAARAA HHHHHHHHHHHHHHH	37.00	30230243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMC1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMC1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.