ZN407_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN407_HUMAN
• UniProt AC: Q9C0G0
• Protein Name: Zinc finger protein 407
• Gene Name: ZNF407
• Organism: Homo sapiens (Human).
• Sequence Length: 2248
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation..
• Protein Sequence: MMDSENKPENDEDEKINKEAQDLTKLSSHNEDGGPVSDVIASFPENSMGKRGFSESSNSDSVVIGEDRNKHASKRRKLDEAEPLKSGKQGICRLETSESSVTEGGIALDETGKETFLSDCTVGGTCLPNALSPSCNFSTIDVVSLKTDTEKTSAQEMVSLDLERESPFPPKEISVSCTIGNVDTVLKCSICGHLFSSCSDLEKHAESHMQQPKEHTCCHCSHKAESSSALHMHIKQAHGPQKVFSCDLCGFQCSEENLLNAHYLGKTHLRRQNLAARGGFVQILTKQPFPKKSRTMATKNVHSKPRTSKSIAKNSDSKGLRNVGSTFKDFRGSISKQSGSSSELLVEMMPSRNTLSQEVEIVEEHVTSLGLAQNPENQSRKLDTLVTSEGLLEKLESTKNTLQAAHGNSVTSRPRPERNILVLGNSFRRRSSTFTLKGQAKKRFNLLGIKRGTSETQRMYMKHLRTQMKTHDAESVLKHLEACSSVQRVCVTTSETQEAEQGQGSARPPDSGLHSLTVKPASGSQTLCACTDCGQVATNRTDLEIHVKRCHAREMKFYCRTCDFSSMSRRDLDEHLHSNQHQQTASVLSCQCCSFISLDEINLRDHMKEKHNMHFLCTPCNLFFLSEKDVEEHKATEKHINSLVQPKTLQSSNSDLVLQTLPLSTLESENAKESMDDSGKASQEEPLKSRVSHGNEVRHSSKPQFQCKKCFYKTRSSTVLTRHIKLRHGQDYHFLCKACNLYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCIGANDKKEEFDVSGNGRIEGHIGVQLQEHSYLEKGMLASEELSQSGGSTKDDELASTTTPKRGRPKGNISRTCSHCGLLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCATKKHKGRVEIEASGKHSSDIIVGPEGGSLEAGKKNAGSAVTMSDEHANKPAESPTSVLEKPDRGNSIEAEVENVFHSLDGEVNSHLLDKKEQISSEPEDFAQPGDVYSQRDVTGTGENKCLHCEFSAHSSASLELHVKRKHTKEFEFYCMACDYYAVTRREMTRHAATEKHKMKRQSYLNSANVEAGSADMSKNIIMPEEEHQQNSEEFQIISGQPSDTLKSRNAADCSILNENTNLDMSKVLCAADSVEVETEEESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSPSRFQNENSGSSALNCETAKKNHEISNDAGELRVHCEGEGGNAGDGGGVVPHRHLCPVTLDGERSAESPVLVVTRITREQGNLESGGQNRVARGHGLEDLKGVQEDPVLGNKEILMNSQHETEFILEEDGPASDSTVESSDVYETIISIDDKGQAMYSFGRFDSSIIRIKNPEDGELIDQSEEGLIATGVRISELPLKDCAQGVKKKKSEGSSIGESTRIRCDDCGFLADGLSGLNVHIAMKHPTKEKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCTEPFDSEQNLFLHIKGQHEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICHFATAQLGDARNHVKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHGVGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWPTCHYSFLTASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNVPVEFRNHLKEQHPDIENPDLAYLHAGIVSKSYECRLKGQGATFVETDSPFTAAALAEEPLVKEKPLRSSRRPAPPPEQVQQVIIFQGYDGEFALDPSVEETAAATLQTLAMAGQVARVVHITEDGQVIATSQSGAHVGSVVPGPILPEQLADGATQVVVVGGSMEGHGMDESLSPGGAVIQQVTKQEILNLSEAGVAPPEASSALDALLCAVTELGEVEGRAGLEEQGRPGAKDVLIQLPGQEVSHVAADPEAPEIQMFPQAQESPAAVEVLTQVVHPSAAMASQERAQVAFKKMVQGVLQFAVCDTAAAGQLVKDGVTQVVVSEEGAVHMVAGEGAQIIMQEAQGEHMDLVESDGEISQIIVTEELVQAMVQESSGGFSEGTTHYILTELPPGVQDEPGLYSHTVLETADSQELLQAGATLGTEAGAPSRAEQLASVVIYTQEGSSAAAAIQSQRESSELQEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Acetylation	FPENSMGKRGFSESS CCCCCCCCCCCCCCC	40.48	25953088
54	Phosphorylation	SMGKRGFSESSNSDS CCCCCCCCCCCCCCC	39.12	-
56	Phosphorylation	GKRGFSESSNSDSVV CCCCCCCCCCCCCEE	33.35	-
125	Phosphorylation	SDCTVGGTCLPNALS CCCCCCCEECCCCCC	12.63	28348404
132	Phosphorylation	TCLPNALSPSCNFST EECCCCCCCCCCCCE	16.62	28348404
134	Phosphorylation	LPNALSPSCNFSTID CCCCCCCCCCCCEEE	20.51	28348404
138	Phosphorylation	LSPSCNFSTIDVVSL CCCCCCCCEEEEEEE	15.51	28348404
139	Phosphorylation	SPSCNFSTIDVVSLK CCCCCCCEEEEEEEC	19.63	28348404
277	Methylation	RRQNLAARGGFVQIL HHHHHHHCCCCEEEE	39.91	58860399
293	Phosphorylation	KQPFPKKSRTMATKN CCCCCCCCCCCCCCC	38.83	20166139
295	Phosphorylation	PFPKKSRTMATKNVH CCCCCCCCCCCCCCC	20.46	20166139
315	Phosphorylation	SKSIAKNSDSKGLRN CCHHHHCCCCCCCCC	42.42	18452278
333	Phosphorylation	TFKDFRGSISKQSGS HHHHHHHCHHCCCCC	21.31	28348404
335	Phosphorylation	KDFRGSISKQSGSSS HHHHHCHHCCCCCCH	26.75	-
351	Phosphorylation	LLVEMMPSRNTLSQE HHHHHCCCCCCCCCH	21.92	-
381	Ubiquitination	NPENQSRKLDTLVTS CCCCCHHHHHEECCC	56.83	29967540
394	Ubiquitination	TSEGLLEKLESTKNT CCHHHHHHHHHHHHH	58.48	29967540
426	Phosphorylation	NILVLGNSFRRRSST CEEEECCCCCCCCCC	20.52	23403867
431	Phosphorylation	GNSFRRRSSTFTLKG CCCCCCCCCCEEECC	31.73	27251275
469	Ubiquitination	KHLRTQMKTHDAESV HHHHHHHHHCCHHHH	32.65	29967540
475	Phosphorylation	MKTHDAESVLKHLEA HHHCCHHHHHHHHHH	34.17	22468782
548	Ubiquitination	TDLEIHVKRCHAREM CCCEEHHHHHHHHHC	34.84	29967540
568	Phosphorylation	TCDFSSMSRRDLDEH CCCCCCCCHHHHHHH	26.55	18669648
634	Acetylation	EKDVEEHKATEKHIN HHHHHHHHHHHHHHH	61.35	25953088
638	Ubiquitination	EEHKATEKHINSLVQ HHHHHHHHHHHHHHC	45.49	29967540
678	Phosphorylation	AKESMDDSGKASQEE HHHHCCCCCCCCCCC	37.62	29523821
680	Ubiquitination	ESMDDSGKASQEEPL HHCCCCCCCCCCCCC	49.14	23503661
680 (in isoform 2)	Ubiquitination	-	49.14	-
682	Phosphorylation	MDDSGKASQEEPLKS CCCCCCCCCCCCCHH	41.43	29523821
688	Ubiquitination	ASQEEPLKSRVSHGN CCCCCCCHHHCCCCC	47.10	23503661
688 (in isoform 2)	Ubiquitination	-	47.10	-
689	Phosphorylation	SQEEPLKSRVSHGNE CCCCCCHHHCCCCCC	45.67	18452278
702	Ubiquitination	NEVRHSSKPQFQCKK CCCCCCCCCCCCCCC	45.94	29967540
717	Phosphorylation	CFYKTRSSTVLTRHI CEEECCCCCEEEEEE	21.17	-
718	Phosphorylation	FYKTRSSTVLTRHIK EEECCCCCEEEEEEE	22.30	-
721	Phosphorylation	TRSSTVLTRHIKLRH CCCCCEEEEEEECCC	18.83	-
746	Ubiquitination	CNLYSLSKEGMEKHI CCCHHCCHHHHHHHH	64.68	29967540
822	Phosphorylation	MLASEELSQSGGSTK CCCCHHHHHCCCCCC	26.11	29255136
824	Phosphorylation	ASEELSQSGGSTKDD CCHHHHHCCCCCCCC	41.57	29255136
827	Phosphorylation	ELSQSGGSTKDDELA HHHHCCCCCCCCHHH	35.49	29255136
828	Phosphorylation	LSQSGGSTKDDELAS HHHCCCCCCCCHHHC	41.59	29255136
835	Phosphorylation	TKDDELASTTTPKRG CCCCHHHCCCCCCCC	38.62	23312004
836	Phosphorylation	KDDELASTTTPKRGR CCCHHHCCCCCCCCC	29.14	28674419
837	Phosphorylation	DDELASTTTPKRGRP CCHHHCCCCCCCCCC	38.31	23312004
838	Phosphorylation	DELASTTTPKRGRPK CHHHCCCCCCCCCCC	27.22	21815630
937	Phosphorylation	AGKKNAGSAVTMSDE CCCCCCCCCEECCHH	19.70	26074081
940	Phosphorylation	KNAGSAVTMSDEHAN CCCCCCEECCHHHCC	15.63	26074081
942	Phosphorylation	AGSAVTMSDEHANKP CCCCEECCHHHCCCC	30.40	26074081
952	Phosphorylation	HANKPAESPTSVLEK HCCCCCCCCCCHHCC	35.27	23401153
954	Phosphorylation	NKPAESPTSVLEKPD CCCCCCCCCHHCCCC	40.52	23663014
955	Phosphorylation	KPAESPTSVLEKPDR CCCCCCCCHHCCCCC	28.26	23663014
993	Phosphorylation	LDKKEQISSEPEDFA CCHHHHHCCCCCHHC	28.48	30266825
994	Phosphorylation	DKKEQISSEPEDFAQ CHHHHHCCCCCHHCC	59.82	30266825
1076	Phosphorylation	KHKMKRQSYLNSANV HHHHHHHHHHHHCCC	35.30	28555341
1121	Phosphorylation	QPSDTLKSRNAADCS CCCHHHHCCCHHHCC	33.60	21659604
1128	Phosphorylation	SRNAADCSILNENTN CCCHHHCCCCCCCCC	30.56	21659604
1187	Phosphorylation	PEEMMSLTMSSNYGS HHHHHHHHHCCCCCC	14.01	-
1189	Phosphorylation	EMMSLTMSSNYGSPS HHHHHHHCCCCCCCH	15.36	30108239
1190	Phosphorylation	MMSLTMSSNYGSPSR HHHHHHCCCCCCCHH	24.21	30108239
1192	Phosphorylation	SLTMSSNYGSPSRFQ HHHHCCCCCCCHHCC	22.41	26074081
1194	Phosphorylation	TMSSNYGSPSRFQNE HHCCCCCCCHHCCCC	14.89	30108239
1196	Phosphorylation	SSNYGSPSRFQNENS CCCCCCCHHCCCCCC	47.64	30108239
1203	Phosphorylation	SRFQNENSGSSALNC HHCCCCCCCCCCCCC	33.60	-
1205	Phosphorylation	FQNENSGSSALNCET CCCCCCCCCCCCCHH	16.56	22210691
1206	Phosphorylation	QNENSGSSALNCETA CCCCCCCCCCCCHHH	40.06	24275569
1212	Phosphorylation	SSALNCETAKKNHEI CCCCCCHHHHHHCCC	46.08	22210691
1214	Acetylation	ALNCETAKKNHEISN CCCCHHHHHHCCCCC	62.62	25953088
1220	Phosphorylation	AKKNHEISNDAGELR HHHHCCCCCCCCCEE	26.18	30108239
1259	Phosphorylation	VTLDGERSAESPVLV EEECCCCCCCCCEEE	31.89	30266825
1262	Phosphorylation	DGERSAESPVLVVTR CCCCCCCCCEEEEEE	21.74	23401153
1268	Phosphorylation	ESPVLVVTRITREQG CCCEEEEEEEEECCC	14.63	23403867
1279	Phosphorylation	REQGNLESGGQNRVA ECCCCCCCCCCCCCC	51.92	27174698
1358	Phosphorylation	YSFGRFDSSIIRIKN EEECCCCCCEEEECC	22.26	25003641
1359	Phosphorylation	SFGRFDSSIIRIKNP EECCCCCCEEEECCC	24.71	30001349
1364	Ubiquitination	DSSIIRIKNPEDGEL CCCEEEECCCCCCCC	57.51	22817900
1364 (in isoform 2)	Ubiquitination	-	57.51	21906983
1364 (in isoform 1)	Ubiquitination	-	57.51	21906983
1364 (in isoform 3)	Ubiquitination	-	57.51	21906983
1403	Phosphorylation	QGVKKKKSEGSSIGE HCCCCCCCCCCCCCC	56.95	-
1407	Phosphorylation	KKKSEGSSIGESTRI CCCCCCCCCCCCCEE	45.53	-
1411	Phosphorylation	EGSSIGESTRIRCDD CCCCCCCCCEEEECC	20.13	-
1412	Phosphorylation	GSSIGESTRIRCDDC CCCCCCCCEEEECCC	26.30	-
1475	Phosphorylation	HMRNEQASVEELPEG CCCCCCCCHHHCCCC	29.74	28857561
1492	Phosphorylation	TFKCVKCTEPFDSEQ EEEEEEECCCCCCCC	40.76	-
1497	Phosphorylation	KCTEPFDSEQNLFLH EECCCCCCCCCEEEE	41.27	-
1518	Ubiquitination	ELLREVNKYIVEDTE HHHHHHHHHHHCCHH	41.34	29967540
1548	Phosphorylation	YCGKMCRSSNSMAFL HHHHHCCCCCCHHHH	29.01	22210691
1551	Phosphorylation	KMCRSSNSMAFLAHI HHCCCCCCHHHHHHH	17.28	22210691
1565	Acetylation	IRTHTGSKPFKCKIC HHHHCCCCCEECEEC	56.68	20167786
1596	Sumoylation	HLGMREYKCHVCGVA HHCCCHHCCCCCCHH	17.08	-
1651	Phosphorylation	NNHMKLHTGEKPFKC HCCCCCCCCCCCCCC	58.43	18669648
1654	Sumoylation	MKLHTGEKPFKCTWP CCCCCCCCCCCCCCC	58.04	-
1654	Sumoylation	MKLHTGEKPFKCTWP CCCCCCCCCCCCCCC	58.04	-
1665	Phosphorylation	CTWPTCHYSFLTASA CCCCCCCEEECCHHH	11.85	-
1677	Phosphorylation	ASAMKDHYRTHTGEK HHHHHHHHHCCCCCC	27.60	-
1679	Phosphorylation	AMKDHYRTHTGEKSF HHHHHHHCCCCCCEE	19.34	-
1681	Phosphorylation	KDHYRTHTGEKSFLC HHHHHCCCCCCEEHH	46.56	-
1685	Phosphorylation	RTHTGEKSFLCDLCG HCCCCCCEEHHHHCC	21.10	-
1703	Ubiquitination	GTRHALTKHRRQHTG HHHHHHHHHHHHHCC	35.64	23503661
1703 (in isoform 2)	Ubiquitination	-	35.64	-
1737	Phosphorylation	TRHKRVHTGEKPYRC HCCCCCCCCCCCCCC	44.15	-
1740	Ubiquitination	KRVHTGEKPYRCPWC CCCCCCCCCCCCCCC	49.01	-
1793	Ubiquitination	VEFRNHLKEQHPDIE HHHHHHHHHHCCCCC	48.02	29967540
1814	Ubiquitination	LHAGIVSKSYECRLK EEEEEECCEEEEEEC	46.28	29967540
1826	Phosphorylation	RLKGQGATFVETDSP EECCCCCEEEECCCC	34.73	24719451
1832	Phosphorylation	ATFVETDSPFTAAAL CEEEECCCCCHHHHH	29.36	24719451
1846	Ubiquitination	LAEEPLVKEKPLRSS HHCCCCCCCCCCCCC	68.64	29967540
1956	Phosphorylation	EGHGMDESLSPGGAV CCCCCCCCCCCCCHH	29.86	26074081
1958	Phosphorylation	HGMDESLSPGGAVIQ CCCCCCCCCCCHHHE	30.67	26074081
2077	Acetylation	ERAQVAFKKMVQGVL HHHHHHHHHHHHHHH	30.16	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN407_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN407_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN407_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBTB9_HUMAN	ZBTB9	physical	20211142
ZSCA1_HUMAN	ZSCAN1	physical	20211142

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.