AN32E_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN32E_HUMAN
• UniProt AC: Q9BTT0
• Protein Name: Acidic leucine-rich nuclear phosphoprotein 32 family member E
• Gene Name: ANP32E
• Organism: Homo sapiens (Human).
• Sequence Length: 268
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. [PubMed: 24463511 Inhibits activity of protein phosphatase 2A (PP2A Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.]
• Protein Sequence: MEMKKKINLELRNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDDDYVEEGEEEEEEEEGGLRGEKRKRDAEDDGEEEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEMKKKIN -------CCCHHHHC	11.65	22814378
5	Ubiquitination	---MEMKKKINLELR ---CCCHHHHCHHHC	58.54	-
6	Sumoylation	--MEMKKKINLELRN --CCCHHHHCHHHCC	31.17	-
6	Ubiquitination	--MEMKKKINLELRN --CCCHHHHCHHHCC	31.17	-
6	Sumoylation	--MEMKKKINLELRN --CCCHHHHCHHHCC	31.17	-
6	2-Hydroxyisobutyrylation	--MEMKKKINLELRN --CCCHHHHCHHHCC	31.17	-
12	Methylation	KKINLELRNRSPEEV HHHCHHHCCCCHHHH	27.43	115481755
15	Phosphorylation	NLELRNRSPEEVTEL CHHHCCCCHHHHHHH	39.97	22468782
17	Ubiquitination	ELRNRSPEEVTELVL HHCCCCHHHHHHHHH	67.36	21890473
53	Ubiquitination	FLSMANVELSSLARL HHHHHCCCHHHHCCC	42.62	21890473
56	Phosphorylation	MANVELSSLARLPSL HHCCCHHHHCCCCCH	38.38	30387612
62	Phosphorylation	SSLARLPSLNKLRKL HHHCCCCCHHHHHCC	49.52	28464451
65	Acetylation	ARLPSLNKLRKLELS CCCCCHHHHHCCCCC	55.77	25953088
65	Ubiquitination	ARLPSLNKLRKLELS CCCCCHHHHHCCCCC	55.77	21890473
65	Ubiquitination	ARLPSLNKLRKLELS CCCCCHHHHHCCCCC	55.77	21890473
65	2-Hydroxyisobutyrylation	ARLPSLNKLRKLELS CCCCCHHHHHCCCCC	55.77	-
68	Sumoylation	PSLNKLRKLELSDNI CCHHHHHCCCCCCCC	57.67	28112733
68	Ubiquitination	PSLNKLRKLELSDNI CCHHHHHCCCCCCCC	57.67	21890473
68	Sumoylation	PSLNKLRKLELSDNI CCHHHHHCCCCCCCC	57.67	-
68	2-Hydroxyisobutyrylation	PSLNKLRKLELSDNI CCHHHHHCCCCCCCC	57.67	-
77	Phosphorylation	ELSDNIISGGLEVLA CCCCCCHHHHHHHHH	24.02	28348404
86	Ubiquitination	GLEVLAEKCPNLTYL HHHHHHHHCCCCEEE	49.76	-
91	Phosphorylation	AEKCPNLTYLNLSGN HHHCCCCEEEECCCC	32.38	28152594
92	Phosphorylation	EKCPNLTYLNLSGNK HHCCCCEEEECCCCC	9.21	28152594
96	Phosphorylation	NLTYLNLSGNKIKDL CCEEEECCCCCCCCC	38.97	28152594
99	Ubiquitination	YLNLSGNKIKDLSTV EEECCCCCCCCCHHH	55.44	21906983
99	Sumoylation	YLNLSGNKIKDLSTV EEECCCCCCCCCHHH	55.44	-
99	Acetylation	YLNLSGNKIKDLSTV EEECCCCCCCCCHHH	55.44	25953088
99	Sumoylation	YLNLSGNKIKDLSTV EEECCCCCCCCCHHH	55.44	-
101	2-Hydroxyisobutyrylation	NLSGNKIKDLSTVEA ECCCCCCCCCHHHHH	54.98	-
101	Sumoylation	NLSGNKIKDLSTVEA ECCCCCCCCCHHHHH	54.98	-
101	Ubiquitination	NLSGNKIKDLSTVEA ECCCCCCCCCHHHHH	54.98	21890473
101	Sumoylation	NLSGNKIKDLSTVEA ECCCCCCCCCHHHHH	54.98	-
104	Phosphorylation	GNKIKDLSTVEALQN CCCCCCCHHHHHHHH	40.31	25159151
105	Phosphorylation	NKIKDLSTVEALQNL CCCCCCHHHHHHHHH	29.66	21712546
113	2-Hydroxyisobutyrylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	-
113	Succinylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	23954790
113	Sumoylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	-
113	Ubiquitination	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	21890473
113	Sumoylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	-
113	Acetylation	VEALQNLKNLKSLDL HHHHHHHHCCCCCCC	68.72	23954790
116	Ubiquitination	LQNLKNLKSLDLFNC HHHHHCCCCCCCCCC	59.37	21906983
117	Phosphorylation	QNLKNLKSLDLFNCE HHHHCCCCCCCCCCE	30.22	21712546
219	Phosphorylation	GEEEVGLSYLMKEEI CHHHHHHHHHHHHHH	15.42	26074081
220	Phosphorylation	EEEVGLSYLMKEEIQ HHHHHHHHHHHHHHC	18.83	26074081
223	Sumoylation	VGLSYLMKEEIQDEE HHHHHHHHHHHCCCC	49.99	-
235	Phosphorylation	DEEDDDDYVEEGEEE CCCCCCCCHHCCHHH	19.43	28674151
254	Ubiquitination	EGGLRGEKRKRDAED HCCCCCHHHCCCCCC	67.07	2190698
254	Acetylation	EGGLRGEKRKRDAED HCCCCCHHHCCCCCC	67.07	26051181
256	Sumoylation	GLRGEKRKRDAEDDG CCCCHHHCCCCCCCC	66.74	-
256	Sumoylation	GLRGEKRKRDAEDDG CCCCHHHCCCCCCCC	66.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN32E_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN32E_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN32E_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RS2_HUMAN	RPS2	physical	22939629
SNX2_HUMAN	SNX2	physical	22863883
SNX6_HUMAN	SNX6	physical	22863883
SAHH2_HUMAN	AHCYL1	physical	26344197
SAHH3_HUMAN	AHCYL2	physical	26344197
DMAP1_HUMAN	DMAP1	physical	26344197
PAPP1_HUMAN	PAPPA	physical	26344197
VPS72_HUMAN	VPS72	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-235, AND MASSSPECTROMETRY.
PubMed: 17287340