SF3B5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SF3B5_HUMAN
• UniProt AC: Q9BWJ5
• Protein Name: Splicing factor 3B subunit 5
• Gene Name: SF3B5
• Organism: Homo sapiens (Human).
• Sequence Length: 86
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. [PubMed: 27720643]
• Protein Sequence: MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENESKARVRFNLMEKMLQPCGPPADKPEEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTDRYTIHS ------CCCCEEHHH	29.23	20068231
2	Acetylation	------MTDRYTIHS ------CCCCEEHHH	29.23	19413330
5	Phosphorylation	---MTDRYTIHSQLE ---CCCCEEHHHHHH	16.92	29978859
6	Phosphorylation	--MTDRYTIHSQLEH --CCCCEEHHHHHHH	17.07	26074081
9	Phosphorylation	TDRYTIHSQLEHLQS CCCEEHHHHHHHHHH	32.39	17525332
16	Phosphorylation	SQLEHLQSKYIGTGH HHHHHHHHCCCCCCC	33.51	27080861
17	Acetylation	QLEHLQSKYIGTGHA HHHHHHHCCCCCCCC	28.11	19608861
17	Ubiquitination	QLEHLQSKYIGTGHA HHHHHHHCCCCCCCC	28.11	22053931
18	Phosphorylation	LEHLQSKYIGTGHAD HHHHHHCCCCCCCCC	15.16	28152594
18	Nitration	LEHLQSKYIGTGHAD HHHHHHCCCCCCCCC	15.16	-
28	Acetylation	TGHADTTKWEWLVNQ CCCCCHHHHHHHHHH	45.25	25825284
28	Ubiquitination	TGHADTTKWEWLVNQ CCCCCHHHHHHHHHH	45.25	22817900
69	Sulfoxidation	ARVRFNLMEKMLQPC HHHHHHHHHHHHCCC	4.96	21406390
71	Ubiquitination	VRFNLMEKMLQPCGP HHHHHHHHHHCCCCC	30.83	21963094
71	Acetylation	VRFNLMEKMLQPCGP HHHHHHHHHHCCCCC	30.83	26051181
72	Sulfoxidation	RFNLMEKMLQPCGPP HHHHHHHHHCCCCCC	2.40	21406390
76	Glutathionylation	MEKMLQPCGPPADKP HHHHHCCCCCCCCCC	9.13	22555962
82	Acetylation	PCGPPADKPEEN--- CCCCCCCCCCCC---	57.33	26822725
82	Ubiquitination	PCGPPADKPEEN--- CCCCCCCCCCCC---	57.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SF3B5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SF3B5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SF3B5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMD1_HUMAN	SNRPD1	physical	22939629
SPF30_HUMAN	SMNDC1	physical	22939629
SNRPA_HUMAN	SNRPA	physical	22939629
SIM20_HUMAN	SMIM20	physical	22939629
SPEB_HUMAN	AGMAT	physical	22939629
VRK1_HUMAN	VRK1	physical	22939629
STRN_HUMAN	STRN	physical	22939629
TOX4_HUMAN	TOX4	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.
PubMed: 17525332