IF16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF16_HUMAN
• UniProt AC: Q16666
• Protein Name: Gamma-interferon-inducible protein 16
• Gene Name: IFI16
• Organism: Homo sapiens (Human).
• Sequence Length: 785
• Subcellular Localization: Nucleus. Cytoplasm. Cellular distribution is dependent on the acetylation status of the multipartite nuclear localization signal (NLS); NLS acetylation promotes cytoplasmic localization. Localizes in the nucleus during human herpes simplex virus 1 (H
• Protein Description: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer..
• Protein Sequence: MGKKYKNIVLLKGLEVINDYHFRMVKSLLSNDLKLNLKMREEYDKIQIADLMEEKFRGDAGLGKLIKIFEDIPTLEDLAETLKKEKLKVKGPALSRKRKKEVDATSPAPSTSSTVKTEGAEATPGAQKRKKSTKEKAGPKGSKVSEEQTQPPSPAGAGMSTAMGRSPSPKTSLSAPPNSSSTENPKTVAKCQVTPRRNVLQKRPVIVKVLSTTKPFEYETPEMEKKIMFHATVATQTQFFHVKVLNTSLKEKFNGKKIIIISDYLEYDSLLEVNEESTVSEAGPNQTFEVPNKIINRAKETLKIDILHKQASGNIVYGVFMLHKKTVNQKTTIYEIQDDRGKMDVVGTGQCHNIPCEEGDKLQLFCFRLRKKNQMSKLISEMHSFIQIKKKTNPRNNDPKSMKLPQEQRQLPYPSEASTTFPESHLRTPQMPPTTPSSSFFTKKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTKSEDTISKMNDFMRMQILKEGSHFPGPFMTSIGPAESHPHTPQMPPSTPSSSFLTTLKPRLKTEPEEVSIEDSAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLKEKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASVTPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGRLTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNKKDILNPDSSMETSPDFFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MGKKYKNIVLLKG --CCCCCCCEEEEEC	49.42	29967540
20	Phosphorylation	GLEVINDYHFRMVKS CHHEECHHHHHHHHH	9.81	-
26	Acetylation	DYHFRMVKSLLSNDL HHHHHHHHHHHCCCH	26.50	25953088
26	Ubiquitination	DYHFRMVKSLLSNDL HHHHHHHHHHHCCCH	26.50	-
34	Ubiquitination	SLLSNDLKLNLKMRE HHHCCCHHHCHHHHH	37.89	32015554
45	Acetylation	KMREEYDKIQIADLM HHHHHHHHHCHHHHH	35.29	22691496
55	2-Hydroxyisobutyrylation	IADLMEEKFRGDAGL HHHHHHHHHCCCCCH	27.36	-
55	Ubiquitination	IADLMEEKFRGDAGL HHHHHHHHHCCCCCH	27.36	29967540
64	Acetylation	RGDAGLGKLIKIFED CCCCCHHHHHHHHCC	52.67	23749302
64	Ubiquitination	RGDAGLGKLIKIFED CCCCCHHHHHHHHCC	52.67	22505724
67	Ubiquitination	AGLGKLIKIFEDIPT CCHHHHHHHHCCCCC	52.35	29967540
68	Ubiquitination	GLGKLIKIFEDIPTL CHHHHHHHHCCCCCH	3.47	22505724
74	Phosphorylation	KIFEDIPTLEDLAET HHHCCCCCHHHHHHH	43.01	25338102
83	Sumoylation	EDLAETLKKEKLKVK HHHHHHHHHHHCCCC	67.32	-
83	Ubiquitination	EDLAETLKKEKLKVK HHHHHHHHHHHCCCC	67.32	21906983
83 (in isoform 1)	Ubiquitination	-	67.32	21906983
83 (in isoform 2)	Ubiquitination	-	67.32	21906983
83 (in isoform 3)	Ubiquitination	-	67.32	21906983
84	Ubiquitination	DLAETLKKEKLKVKG HHHHHHHHHHCCCCC	64.29	22817900
86	Acetylation	AETLKKEKLKVKGPA HHHHHHHHCCCCCHH	63.59	69243
86	Ubiquitination	AETLKKEKLKVKGPA HHHHHHHHCCCCCHH	63.59	22817900
87	Ubiquitination	ETLKKEKLKVKGPAL HHHHHHHCCCCCHHH	8.93	22817900
88	Ubiquitination	TLKKEKLKVKGPALS HHHHHHCCCCCHHHC	53.63	22817900
90	Ubiquitination	KKEKLKVKGPALSRK HHHHCCCCCHHHCCC	58.55	22817900
92	Ubiquitination	EKLKVKGPALSRKRK HHCCCCCHHHCCCCC	25.06	22817900
94	Ubiquitination	LKVKGPALSRKRKKE CCCCCHHHCCCCCCC	5.99	22505724
95	Phosphorylation	KVKGPALSRKRKKEV CCCCHHHCCCCCCCC	37.55	22691496
97	Ubiquitination	KGPALSRKRKKEVDA CCHHHCCCCCCCCCC	66.26	22817900
99	Acetylation	PALSRKRKKEVDATS HHHCCCCCCCCCCCC	57.21	22691496
99	Ubiquitination	PALSRKRKKEVDATS HHHCCCCCCCCCCCC	57.21	21963094
100	Ubiquitination	ALSRKRKKEVDATSP HHCCCCCCCCCCCCC	67.98	22817900
101	Ubiquitination	LSRKRKKEVDATSPA HCCCCCCCCCCCCCC	48.98	22817900
103	Ubiquitination	RKRKKEVDATSPAPS CCCCCCCCCCCCCCC	45.26	21963094
104	Ubiquitination	KRKKEVDATSPAPST CCCCCCCCCCCCCCC	18.36	22817900
105	Phosphorylation	RKKEVDATSPAPSTS CCCCCCCCCCCCCCC	30.68	29255136
106	Phosphorylation	KKEVDATSPAPSTSS CCCCCCCCCCCCCCC	22.30	29255136
110	Phosphorylation	DATSPAPSTSSTVKT CCCCCCCCCCCCCCC	42.92	30266825
111	Phosphorylation	ATSPAPSTSSTVKTE CCCCCCCCCCCCCCC	26.15	30266825
112	Phosphorylation	TSPAPSTSSTVKTEG CCCCCCCCCCCCCCC	28.48	30266825
113	Phosphorylation	SPAPSTSSTVKTEGA CCCCCCCCCCCCCCC	36.99	30266825
114	Phosphorylation	PAPSTSSTVKTEGAE CCCCCCCCCCCCCCC	26.28	30266825
116	Sumoylation	PSTSSTVKTEGAEAT CCCCCCCCCCCCCCC	40.73	-
116	Acetylation	PSTSSTVKTEGAEAT CCCCCCCCCCCCCCC	40.73	26051181
116	Sumoylation	PSTSSTVKTEGAEAT CCCCCCCCCCCCCCC	40.73	28112733
116	Ubiquitination	PSTSSTVKTEGAEAT CCCCCCCCCCCCCCC	40.73	21963094
117	Phosphorylation	STSSTVKTEGAEATP CCCCCCCCCCCCCCC	35.00	23403867
120	Ubiquitination	STVKTEGAEATPGAQ CCCCCCCCCCCCCCH	9.30	21963094
123	Phosphorylation	KTEGAEATPGAQKRK CCCCCCCCCCCHHCC	17.48	29255136
128	Acetylation	EATPGAQKRKKSTKE CCCCCCHHCCCCHHC	66.70	22691496
128	Sumoylation	EATPGAQKRKKSTKE CCCCCCHHCCCCHHC	66.70	28112733
128	Ubiquitination	EATPGAQKRKKSTKE CCCCCCHHCCCCHHC	66.70	21906983
128 (in isoform 1)	Ubiquitination	-	66.70	21906983
128 (in isoform 2)	Ubiquitination	-	66.70	21906983
128 (in isoform 3)	Ubiquitination	-	66.70	21906983
130	Ubiquitination	TPGAQKRKKSTKEKA CCCCHHCCCCHHCCC	59.10	22817900
131	Ubiquitination	PGAQKRKKSTKEKAG CCCHHCCCCHHCCCC	68.35	22817900
132	Phosphorylation	GAQKRKKSTKEKAGP CCHHCCCCHHCCCCC	47.98	26670566
132	Ubiquitination	GAQKRKKSTKEKAGP CCHHCCCCHHCCCCC	47.98	22817900
133	Phosphorylation	AQKRKKSTKEKAGPK CHHCCCCHHCCCCCC	52.69	26670566
134	Ubiquitination	QKRKKSTKEKAGPKG HHCCCCHHCCCCCCC	65.39	22817900
135	Ubiquitination	KRKKSTKEKAGPKGS HCCCCHHCCCCCCCC	48.50	22817900
140	Ubiquitination	TKEKAGPKGSKVSEE HHCCCCCCCCCCCHH	74.93	24816145
142	Phosphorylation	EKAGPKGSKVSEEQT CCCCCCCCCCCHHHC	35.69	30108239
143	Acetylation	KAGPKGSKVSEEQTQ CCCCCCCCCCHHHCC	59.45	25953088
143	Ubiquitination	KAGPKGSKVSEEQTQ CCCCCCCCCCHHHCC	59.45	22505724
144	Ubiquitination	AGPKGSKVSEEQTQP CCCCCCCCCHHHCCC	10.49	24816145
145	Phosphorylation	GPKGSKVSEEQTQPP CCCCCCCCHHHCCCC	38.87	23927012
146	Ubiquitination	PKGSKVSEEQTQPPS CCCCCCCHHHCCCCC	58.05	29967540
147	Ubiquitination	KGSKVSEEQTQPPSP CCCCCCHHHCCCCCC	51.96	22505724
149	Phosphorylation	SKVSEEQTQPPSPAG CCCCHHHCCCCCCCC	46.45	25159151
152	Acetylation	SEEQTQPPSPAGAGM CHHHCCCCCCCCCCC	43.03	19608861
152	Ubiquitination	SEEQTQPPSPAGAGM CHHHCCCCCCCCCCC	43.03	29967540
153	Phosphorylation	EEQTQPPSPAGAGMS HHHCCCCCCCCCCCC	33.78	29255136
158	Acetylation	PPSPAGAGMSTAMGR CCCCCCCCCCCCCCC	15.06	19608861
158	Ubiquitination	PPSPAGAGMSTAMGR CCCCCCCCCCCCCCC	15.06	29967540
160	Phosphorylation	SPAGAGMSTAMGRSP CCCCCCCCCCCCCCC	16.46	23927012
161	Phosphorylation	PAGAGMSTAMGRSPS CCCCCCCCCCCCCCC	16.27	23401153
166	Phosphorylation	MSTAMGRSPSPKTSL CCCCCCCCCCCCCCC	24.81	25159151
168	Phosphorylation	TAMGRSPSPKTSLSA CCCCCCCCCCCCCCC	40.03	28355574
169	Ubiquitination	AMGRSPSPKTSLSAP CCCCCCCCCCCCCCC	47.53	29967540
171	Phosphorylation	GRSPSPKTSLSAPPN CCCCCCCCCCCCCCC	37.98	27486199
172	Phosphorylation	RSPSPKTSLSAPPNS CCCCCCCCCCCCCCC	26.84	27251275
174	Phosphorylation	PSPKTSLSAPPNSSS CCCCCCCCCCCCCCC	38.20	22691496
179	Phosphorylation	SLSAPPNSSSTENPK CCCCCCCCCCCCCCC	31.29	27486199
180	Phosphorylation	LSAPPNSSSTENPKT CCCCCCCCCCCCCCC	48.17	27486199
181	Phosphorylation	SAPPNSSSTENPKTV CCCCCCCCCCCCCCE	39.29	27486199
182	Phosphorylation	APPNSSSTENPKTVA CCCCCCCCCCCCCEE	41.55	27486199
190	Sumoylation	ENPKTVAKCQVTPRR CCCCCEEECEECCCC	22.36	-
190	Acetylation	ENPKTVAKCQVTPRR CCCCCEEECEECCCC	22.36	25953088
190	Ubiquitination	ENPKTVAKCQVTPRR CCCCCEEECEECCCC	22.36	22505724
194	Phosphorylation	TVAKCQVTPRRNVLQ CEEECEECCCCCHHH	5.79	21815630
194	Ubiquitination	TVAKCQVTPRRNVLQ CEEECEECCCCCHHH	5.79	22817900
196	Ubiquitination	AKCQVTPRRNVLQKR EECEECCCCCHHHCC	33.18	22817900
202	Acetylation	PRRNVLQKRPVIVKV CCCCHHHCCCEEEEE	55.28	25953088
202	Ubiquitination	PRRNVLQKRPVIVKV CCCCHHHCCCEEEEE	55.28	29967540
208	Acetylation	QKRPVIVKVLSTTKP HCCCEEEEECCCCCC	26.74	26051181
208	Ubiquitination	QKRPVIVKVLSTTKP HCCCEEEEECCCCCC	26.74	29967540
211	Phosphorylation	PVIVKVLSTTKPFEY CEEEEECCCCCCCCC	36.70	23312004
212	Phosphorylation	VIVKVLSTTKPFEYE EEEEECCCCCCCCCC	34.38	23312004
213	Phosphorylation	IVKVLSTTKPFEYET EEEECCCCCCCCCCC	33.09	23312004
214	Acetylation	VKVLSTTKPFEYETP EEECCCCCCCCCCCH	48.04	22691496
214	Malonylation	VKVLSTTKPFEYETP EEECCCCCCCCCCCH	48.04	26320211
214	Ubiquitination	VKVLSTTKPFEYETP EEECCCCCCCCCCCH	48.04	29967540
218	Phosphorylation	STTKPFEYETPEMEK CCCCCCCCCCHHHHH	26.02	23312004
220	Phosphorylation	TKPFEYETPEMEKKI CCCCCCCCHHHHHHH	24.52	23312004
225	Acetylation	YETPEMEKKIMFHAT CCCHHHHHHHEEEEE	46.41	25953088
225	Ubiquitination	YETPEMEKKIMFHAT CCCHHHHHHHEEEEE	46.41	29967540
226	Ubiquitination	ETPEMEKKIMFHATV CCHHHHHHHEEEEEE	26.54	-
232	Phosphorylation	KKIMFHATVATQTQF HHHEEEEEEEECCCE	11.34	-
237	Phosphorylation	HATVATQTQFFHVKV EEEEEECCCEEEEEE	24.00	-
243	Ubiquitination	QTQFFHVKVLNTSLK CCCEEEEEEECHHHH	32.22	29967540
247	Ubiquitination	FHVKVLNTSLKEKFN EEEEEECHHHHHHHC	31.13	29967540
248	Phosphorylation	HVKVLNTSLKEKFNG EEEEECHHHHHHHCC	36.05	-
250	Acetylation	KVLNTSLKEKFNGKK EEECHHHHHHHCCEE	59.64	25953088
250	Malonylation	KVLNTSLKEKFNGKK EEECHHHHHHHCCEE	59.64	26320211
250	Ubiquitination	KVLNTSLKEKFNGKK EEECHHHHHHHCCEE	59.64	21906983
250 (in isoform 1)	Ubiquitination	-	59.64	21906983
250 (in isoform 2)	Ubiquitination	-	59.64	21906983
250 (in isoform 3)	Ubiquitination	-	59.64	21906983
252	Ubiquitination	LNTSLKEKFNGKKII ECHHHHHHHCCEEEE	42.41	22817900
254	Ubiquitination	TSLKEKFNGKKIIII HHHHHHHCCEEEEEE	72.88	22817900
256	Ubiquitination	LKEKFNGKKIIIISD HHHHHCCEEEEEEEC	41.73	22817900
269	Ubiquitination	SDYLEYDSLLEVNEE ECCCCCHHCEEECCC	33.67	22817900
274	Ubiquitination	YDSLLEVNEESTVSE CHHCEEECCCCCCCC	37.63	21963094
286	Ubiquitination	VSEAGPNQTFEVPNK CCCCCCCCCEECCHH	51.18	29967540
299	Ubiquitination	NKIINRAKETLKIDI HHHHHHHHHHHCEEE	48.25	29967540
303	Ubiquitination	NRAKETLKIDILHKQ HHHHHHHCEEEEEEC	45.83	29967540
305	Ubiquitination	AKETLKIDILHKQAS HHHHHCEEEEEECCC	35.49	29967540
317	Phosphorylation	QASGNIVYGVFMLHK CCCCCEEEEEEEEEE	12.08	-
321	Ubiquitination	NIVYGVFMLHKKTVN CEEEEEEEEEECCCC	3.39	29967540
324	Acetylation	YGVFMLHKKTVNQKT EEEEEEEECCCCCCE	46.29	25953088
325	Ubiquitination	GVFMLHKKTVNQKTT EEEEEEECCCCCCEE	47.13	22817900
329	Ubiquitination	LHKKTVNQKTTIYEI EEECCCCCCEEEEEE	39.89	22817900
330	Acetylation	HKKTVNQKTTIYEIQ EECCCCCCEEEEEEE	42.29	25953088
330	Malonylation	HKKTVNQKTTIYEIQ EECCCCCCEEEEEEE	42.29	26320211
330	Ubiquitination	HKKTVNQKTTIYEIQ EECCCCCCEEEEEEE	42.29	21963094
332	Phosphorylation	KTVNQKTTIYEIQDD CCCCCCEEEEEEECC	28.70	24719451
333	Ubiquitination	TVNQKTTIYEIQDDR CCCCCEEEEEEECCC	3.34	29967540
334	Phosphorylation	VNQKTTIYEIQDDRG CCCCEEEEEEECCCC	12.60	24719451
334	Ubiquitination	VNQKTTIYEIQDDRG CCCCEEEEEEECCCC	12.60	21963094
342	Acetylation	EIQDDRGKMDVVGTG EEECCCCCEEEEECC	32.59	25953088
342	Ubiquitination	EIQDDRGKMDVVGTG EEECCCCCEEEEECC	32.59	29967540
344	Ubiquitination	QDDRGKMDVVGTGQC ECCCCCEEEEECCCC	35.12	29967540
361	Acetylation	IPCEEGDKLQLFCFR CCCCCCCEEEEEEEE	49.33	25953088
361	Ubiquitination	IPCEEGDKLQLFCFR CCCCCCCEEEEEEEE	49.33	29967540
363	Phosphorylation	CEEGDKLQLFCFRLR CCCCCEEEEEEEEHH	37.93	27251275
377	Acetylation	RKKNQMSKLISEMHS HHHCHHHHHHHHHHH	44.49	23749302
377	Ubiquitination	RKKNQMSKLISEMHS HHHCHHHHHHHHHHH	44.49	29967540
387	Ubiquitination	SEMHSFIQIKKKTNP HHHHHHHHHHHCCCC	39.16	22505724
388	Ubiquitination	EMHSFIQIKKKTNPR HHHHHHHHHHCCCCC	6.37	29967540
389	Acetylation	MHSFIQIKKKTNPRN HHHHHHHHHCCCCCC	31.66	25953088
389	Malonylation	MHSFIQIKKKTNPRN HHHHHHHHHCCCCCC	31.66	26320211
389	Ubiquitination	MHSFIQIKKKTNPRN HHHHHHHHHCCCCCC	31.66	29967540
395	Ubiquitination	IKKKTNPRNNDPKSM HHHCCCCCCCCCCCC	57.57	22505724
400	Acetylation	NPRNNDPKSMKLPQE CCCCCCCCCCCCCHH	67.08	23749302
400	Ubiquitination	NPRNNDPKSMKLPQE CCCCCCCCCCCCCHH	67.08	29967540
406	Ubiquitination	PKSMKLPQEQRQLPY CCCCCCCHHHCCCCC	70.64	29967540
418	Phosphorylation	LPYPSEASTTFPESH CCCCCCCCCCCCHHH	24.75	25159151
419	Phosphorylation	PYPSEASTTFPESHL CCCCCCCCCCCHHHC	39.23	25159151
428	Phosphorylation	FPESHLRTPQMPPTT CCHHHCCCCCCCCCC	25.00	21815630
431	Sulfoxidation	SHLRTPQMPPTTPSS HHCCCCCCCCCCCCC	4.52	28465586
434	Phosphorylation	RTPQMPPTTPSSSFF CCCCCCCCCCCCCCC	45.53	21815630
435	Phosphorylation	TPQMPPTTPSSSFFT CCCCCCCCCCCCCCC	27.26	25159151
437	Phosphorylation	QMPPTTPSSSFFTKK CCCCCCCCCCCCCCC	36.20	21815630
438	Phosphorylation	MPPTTPSSSFFTKKS CCCCCCCCCCCCCCC	32.16	29396449
439	Phosphorylation	PPTTPSSSFFTKKSE CCCCCCCCCCCCCCH	28.81	29396449
442	Phosphorylation	TPSSSFFTKKSEDTI CCCCCCCCCCCHHHH	35.24	29396449
443	Methylation	PSSSFFTKKSEDTIS CCCCCCCCCCHHHHH	49.50	115971349
443	Ubiquitination	PSSSFFTKKSEDTIS CCCCCCCCCCHHHHH	49.50	22505724
443 (in isoform 3)	Ubiquitination	-	49.50	-
444	Sumoylation	SSSFFTKKSEDTISK CCCCCCCCCHHHHHH	56.89	-
444	Acetylation	SSSFFTKKSEDTISK CCCCCCCCCHHHHHH	56.89	22691496
444	Ubiquitination	SSSFFTKKSEDTISK CCCCCCCCCHHHHHH	56.89	29967540
447	Ubiquitination	FFTKKSEDTISKMND CCCCCCHHHHHHHHH	57.33	22505724
448	Phosphorylation	FTKKSEDTISKMNDF CCCCCHHHHHHHHHH	24.09	30576142
449	Ubiquitination	TKKSEDTISKMNDFM CCCCHHHHHHHHHHH	6.03	22817900
451	Sumoylation	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	-
451	Acetylation	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	22691496
451	Ubiquitination	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	22505724
453	Ubiquitination	EDTISKMNDFMRMQI HHHHHHHHHHHHHHH	43.00	22817900
455	Ubiquitination	TISKMNDFMRMQILK HHHHHHHHHHHHHHH	2.58	22505724
456 (in isoform 3)	Phosphorylation	-	3.78	29507054
462	Ubiquitination	FMRMQILKEGSHFPG HHHHHHHHCCCCCCC	62.75	29967540
465	Phosphorylation	MQILKEGSHFPGPFM HHHHHCCCCCCCCCC	24.05	26714015
473	Phosphorylation	HFPGPFMTSIGPAES CCCCCCCCCCCCCCC	19.99	26074081
474	Phosphorylation	FPGPFMTSIGPAESH CCCCCCCCCCCCCCC	17.48	26074081
480	Phosphorylation	TSIGPAESHPHTPQM CCCCCCCCCCCCCCC	44.41	25159151
484	Phosphorylation	PAESHPHTPQMPPST CCCCCCCCCCCCCCC	21.48	25159151
490	Phosphorylation	HTPQMPPSTPSSSFL CCCCCCCCCCCCCCC	47.26	25159151
490	Ubiquitination	HTPQMPPSTPSSSFL CCCCCCCCCCCCCCC	47.26	22505724
491	Phosphorylation	TPQMPPSTPSSSFLT CCCCCCCCCCCCCCC	32.72	25159151
493	Phosphorylation	QMPPSTPSSSFLTTK CCCCCCCCCCCCCCC	38.41	25159151
494	Phosphorylation	MPPSTPSSSFLTTKS CCCCCCCCCCCCCCC	26.72	26074081
495	Phosphorylation	PPSTPSSSFLTTKSE CCCCCCCCCCCCCCH	28.72	26074081
499	Phosphorylation	PSSSFLTTKSEDTIS CCCCCCCCCCHHHHH	34.42	26714015
500	Sumoylation	SSSFLTTKSEDTISK CCCCCCCCCHHHHHH	46.76	-
501	Phosphorylation	SSFLTTKSEDTISKM CCCCCCCCHHHHHHH	38.32	22210691
501	Ubiquitination	SSFLTTKSEDTISKM CCCCCCCCHHHHHHH	38.32	22817900
505	Ubiquitination	TTKSEDTISKMNDFM CCCCHHHHHHHHHHH	6.03	32015554
506	Ubiquitination	TKSEDTISKMNDFMR CCCHHHHHHHHHHHH	28.13	23000965
507	Sumoylation	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	-
507	Acetylation	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	25953088
507	Ubiquitination	KSEDTISKMNDFMRM CCHHHHHHHHHHHHH	37.56	-
511	Ubiquitination	TISKMNDFMRMQILK HHHHHHHHHHHHHHH	2.58	22505724
512	Phosphorylation	ISKMNDFMRMQILKE HHHHHHHHHHHHHHC	3.78	27251275
513	Ubiquitination	SKMNDFMRMQILKEG HHHHHHHHHHHHHCC	17.53	22505724
515	Ubiquitination	MNDFMRMQILKEGSH HHHHHHHHHHHCCCC	27.74	22505724
516	Phosphorylation	NDFMRMQILKEGSHF HHHHHHHHHHCCCCC	4.30	27251275
519	Phosphorylation	MRMQILKEGSHFPGP HHHHHHHCCCCCCCC	63.58	20068231
520	Ubiquitination	RMQILKEGSHFPGPF HHHHHHCCCCCCCCC	25.49	22505724
529	Phosphorylation	HFPGPFMTSIGPAES CCCCCCCCCCCCCCC	19.99	26074081
530	Phosphorylation	FPGPFMTSIGPAESH CCCCCCCCCCCCCCC	17.48	26074081
536	Phosphorylation	TSIGPAESHPHTPQM CCCCCCCCCCCCCCC	44.41	25627689
540	Phosphorylation	PAESHPHTPQMPPST CCCCCCCCCCCCCCC	21.48	25627689
542	Ubiquitination	ESHPHTPQMPPSTPS CCCCCCCCCCCCCCC	59.16	22505724
546	Phosphorylation	HTPQMPPSTPSSSFL CCCCCCCCCCCCCCC	47.26	30576142
547	Phosphorylation	TPQMPPSTPSSSFLT CCCCCCCCCCCCCCC	32.72	25627689
549	Phosphorylation	QMPPSTPSSSFLTTL CCCCCCCCCCCCCCC	38.41	26074081
550	Phosphorylation	MPPSTPSSSFLTTLK CCCCCCCCCCCCCCC	26.72	26074081
551	Phosphorylation	PPSTPSSSFLTTLKP CCCCCCCCCCCCCCC	28.72	26074081
554	Phosphorylation	TPSSSFLTTLKPRLK CCCCCCCCCCCCCCC	28.24	28634298
555	Phosphorylation	PSSSFLTTLKPRLKT CCCCCCCCCCCCCCC	34.63	28634298
555	Ubiquitination	PSSSFLTTLKPRLKT CCCCCCCCCCCCCCC	34.63	24816145
557	Acetylation	SSFLTTLKPRLKTEP CCCCCCCCCCCCCCC	26.46	25953088
557	Ubiquitination	SSFLTTLKPRLKTEP CCCCCCCCCCCCCCC	26.46	-
558	Ubiquitination	SFLTTLKPRLKTEPE CCCCCCCCCCCCCCC	50.37	23000965
561	Sumoylation	TTLKPRLKTEPEEVS CCCCCCCCCCCCCCC	52.72	-
561	Acetylation	TTLKPRLKTEPEEVS CCCCCCCCCCCCCCC	52.72	22691496
561	Sumoylation	TTLKPRLKTEPEEVS CCCCCCCCCCCCCCC	52.72	25114211
561	Ubiquitination	TTLKPRLKTEPEEVS CCCCCCCCCCCCCCC	52.72	22817900
562	Phosphorylation	TLKPRLKTEPEEVSI CCCCCCCCCCCCCCH	62.45	28122231
562 (in isoform 3)	Ubiquitination	-	62.45	21906983
565	Ubiquitination	PRLKTEPEEVSIEDS CCCCCCCCCCCHHHH	65.87	22817900
566	Ubiquitination	RLKTEPEEVSIEDSA CCCCCCCCCCHHHHC	52.89	22817900
567	Ubiquitination	LKTEPEEVSIEDSAQ CCCCCCCCCHHHHCC	7.14	22505724
568	Phosphorylation	KTEPEEVSIEDSAQS CCCCCCCCHHHHCCC	24.44	25159151
572	Phosphorylation	EEVSIEDSAQSDLKE CCCCHHHHCCCCCCC	18.54	25159151
572	Ubiquitination	EEVSIEDSAQSDLKE CCCCHHHHCCCCCCC	18.54	22505724
575	Phosphorylation	SIEDSAQSDLKEVMV CHHHHCCCCCCCEEE	44.63	25159151
583 (in isoform 3)	Ubiquitination	-	1.63	21906983
586	Phosphorylation	EVMVLNATESFVYEP CEEEEECCCCEECCC	30.96	28122231
587	Ubiquitination	VMVLNATESFVYEPK EEEEECCCCEECCCH	39.51	22817900
588	Ubiquitination	MVLNATESFVYEPKE EEEECCCCEECCCHH	18.69	22817900
598	Sumoylation	YEPKEQKKMFHATVA CCCHHHHHCEEEEEE	46.63	-
598	Acetylation	YEPKEQKKMFHATVA CCCHHHHHCEEEEEE	46.63	22691496
598	Ubiquitination	YEPKEQKKMFHATVA CCCHHHHHCEEEEEE	46.63	-
602	Ubiquitination	EQKKMFHATVATENE HHHHCEEEEEECCCC	7.78	22505724
607	Ubiquitination	FHATVATENEVFRVK EEEEEECCCCEEEEE	41.47	24816145
614	Acetylation	ENEVFRVKVFNIDLK CCCEEEEEEEECCCC	36.53	22691496
614	Phosphorylation	ENEVFRVKVFNIDLK CCCEEEEEEEECCCC	36.53	27251275
614	Ubiquitination	ENEVFRVKVFNIDLK CCCEEEEEEEECCCC	36.53	-
618	Ubiquitination	FRVKVFNIDLKEKFT EEEEEEECCCCCCCC	4.45	23000965
618 (in isoform 2)	Ubiquitination	-	4.45	21906983
621	Acetylation	KVFNIDLKEKFTPKK EEEECCCCCCCCHHH	55.92	23749302
621	Ubiquitination	KVFNIDLKEKFTPKK EEEECCCCCCCCHHH	55.92	-
623	Ubiquitination	FNIDLKEKFTPKKII EECCCCCCCCHHHHH	53.61	-
624	Ubiquitination	NIDLKEKFTPKKIIA ECCCCCCCCHHHHHH	17.31	22505724
625	Ubiquitination	IDLKEKFTPKKIIAI CCCCCCCCHHHHHHH	45.31	22505724
626	Ubiquitination	DLKEKFTPKKIIAIA CCCCCCCHHHHHHHH	38.79	22505724
627	Ubiquitination	LKEKFTPKKIIAIAN CCCCCCHHHHHHHHH	54.25	22505724
628	Ubiquitination	KEKFTPKKIIAIANY CCCCCHHHHHHHHHH	40.31	-
631 (in isoform 3)	Ubiquitination	-	9.79	21906983
632	Ubiquitination	TPKKIIAIANYVCRN CHHHHHHHHHHHHHC	1.47	22505724
635	Ubiquitination	KIIAIANYVCRNGFL HHHHHHHHHHHCCCE	7.60	22817900
639	Ubiquitination	IANYVCRNGFLEVYP HHHHHHHCCCEEEEC	40.20	22817900
639 (in isoform 2)	Ubiquitination	-	40.20	21906983
640	Ubiquitination	ANYVCRNGFLEVYPF HHHHHHCCCEEEECE	14.79	22817900
657	Ubiquitination	VADVNADRNMEIPKG EEEECCCCCCCCCCH	41.82	22505724
659	Ubiquitination	DVNADRNMEIPKGLI EECCCCCCCCCCHHH	5.28	24816145
660	Ubiquitination	VNADRNMEIPKGLIR ECCCCCCCCCCHHHH	60.74	22505724
663	Malonylation	DRNMEIPKGLIRSAS CCCCCCCCHHHHHCC	72.51	26320211
663	Ubiquitination	DRNMEIPKGLIRSAS CCCCCCCCHHHHHCC	72.51	-
667	Ubiquitination	EIPKGLIRSASVTPK CCCCHHHHHCCCCHH	31.08	24816145
668	Phosphorylation	IPKGLIRSASVTPKI CCCHHHHHCCCCHHH	20.22	29514088
670	Phosphorylation	KGLIRSASVTPKINQ CHHHHHCCCCHHHHH	27.98	26074081
672	Phosphorylation	LIRSASVTPKINQLC HHHHCCCCHHHHHHH	19.17	26074081
674	Malonylation	RSASVTPKINQLCSQ HHCCCCHHHHHHHHC	44.94	32601280
674	Ubiquitination	RSASVTPKINQLCSQ HHCCCCHHHHHHHHC	44.94	21906983
674 (in isoform 1)	Ubiquitination	-	44.94	21906983
676	Ubiquitination	ASVTPKINQLCSQTK CCCCHHHHHHHHCCC	34.59	22505724
678	Ubiquitination	VTPKINQLCSQTKGS CCHHHHHHHHCCCCC	2.34	22817900
683	Sumoylation	NQLCSQTKGSFVNGV HHHHHCCCCCEECEE	44.94	-
683	Sumoylation	NQLCSQTKGSFVNGV HHHHHCCCCCEECEE	44.94	28112733
683	Ubiquitination	NQLCSQTKGSFVNGV HHHHHCCCCCEECEE	44.94	-
687	Ubiquitination	SQTKGSFVNGVFEVH HCCCCCEECEEEEEE	6.98	22817900
687 (in isoform 2)	Ubiquitination	-	6.98	21906983
695	Acetylation	NGVFEVHKKNVRGEF CEEEEEEECCCCCEE	51.74	25953088
695	Ubiquitination	NGVFEVHKKNVRGEF CEEEEEEECCCCCEE	51.74	21906983
695 (in isoform 1)	Ubiquitination	-	51.74	21906983
699	Ubiquitination	EVHKKNVRGEFTYYE EEEECCCCCEEEEEE	48.60	22817900
700	Ubiquitination	VHKKNVRGEFTYYEI EEECCCCCEEEEEEE	30.04	22817900
703	Ubiquitination	KNVRGEFTYYEIQDN CCCCCEEEEEEEECC	22.38	29967540
704	Phosphorylation	NVRGEFTYYEIQDNT CCCCEEEEEEEECCC	12.38	22817900
709	Ubiquitination	FTYYEIQDNTGKMEV EEEEEEECCCCEEEE	61.39	22505724
711	Ubiquitination	YYEIQDNTGKMEVVV EEEEECCCCEEEEEE	46.60	24816145
712	Ubiquitination	YEIQDNTGKMEVVVH EEEECCCCEEEEEEE	33.30	22505724
719	Phosphorylation	GKMEVVVHGRLTTIN CEEEEEEEEEEEEEE	12.21	18669648
720	Phosphorylation	KMEVVVHGRLTTINC EEEEEEEEEEEEEEC	18.06	20068231
723	Phosphorylation	VVVHGRLTTINCEEG EEEEEEEEEEECCCC	25.03	27251275
724	Phosphorylation	VVHGRLTTINCEEGD EEEEEEEEEECCCCC	18.13	24719451
732	Sumoylation	INCEEGDKLKLTCFE EECCCCCEEEEEEEE	59.38	-
732	Acetylation	INCEEGDKLKLTCFE EECCCCCEEEEEEEE	59.38	23749302
732	Ubiquitination	INCEEGDKLKLTCFE EECCCCCEEEEEEEE	59.38	-
734	Sumoylation	CEEGDKLKLTCFELA CCCCCEEEEEEEEEC	47.71	-
734	Acetylation	CEEGDKLKLTCFELA CCCCCEEEEEEEEEC	47.71	23749302
734	Malonylation	CEEGDKLKLTCFELA CCCCCEEEEEEEEEC	47.71	26320211
734	Ubiquitination	CEEGDKLKLTCFELA CCCCCEEEEEEEEEC	47.71	-
736	Ubiquitination	EGDKLKLTCFELAPK CCCEEEEEEEEECCC	17.35	22505724
738	Ubiquitination	DKLKLTCFELAPKSG CEEEEEEEEECCCCC	7.90	22505724
743	Sumoylation	TCFELAPKSGNTGEL EEEEECCCCCCCHHH	66.44	-
743	Ubiquitination	TCFELAPKSGNTGEL EEEEECCCCCCCHHH	66.44	2190698
743 (in isoform 1)	Ubiquitination	-	66.44	21906983
747	Ubiquitination	LAPKSGNTGELRSVI ECCCCCCCHHHHHHH	35.24	22817900
759	Acetylation	SVIHSHIKVIKTRKN HHHHHHHEEEECCCC	32.27	23749302
759	Ubiquitination	SVIHSHIKVIKTRKN HHHHHHHEEEECCCC	32.27	-
767	Ubiquitination	VIKTRKNKKDILNPD EEECCCCHHCCCCCC	55.66	-
768	Ubiquitination	IKTRKNKKDILNPDS EECCCCHHCCCCCCC	60.43	-
769	Ubiquitination	KTRKNKKDILNPDSS ECCCCHHCCCCCCCC	52.82	22505724
771	Ubiquitination	RKNKKDILNPDSSME CCCHHCCCCCCCCCC	12.49	24816145
772	Ubiquitination	KNKKDILNPDSSMET CCHHCCCCCCCCCCC	38.37	22505724
775	Phosphorylation	KDILNPDSSMETSPD HCCCCCCCCCCCCCC	32.61	25159151
776	Phosphorylation	DILNPDSSMETSPDF CCCCCCCCCCCCCCC	28.19	25159151
777	Sulfoxidation	ILNPDSSMETSPDFF CCCCCCCCCCCCCCC	8.25	30846556
779	Phosphorylation	NPDSSMETSPDFFF- CCCCCCCCCCCCCC-	36.60	22115753
780	Phosphorylation	PDSSMETSPDFFF-- CCCCCCCCCCCCC--	14.79	26055452

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
132	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
132	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
132	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:23427152

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP1_HUMAN	SP1	physical	22291595
A4_HUMAN	APP	physical	21832049
ANDR_HUMAN	AR	physical	16494870
STING_HUMAN	TMEM173	physical	20890285
STING_MOUSE	Tmem173	physical	20890285
ACADV_HUMAN	ACADVL	physical	25693804
ACINU_HUMAN	ACIN1	physical	25693804
DSRAD_HUMAN	ADAR	physical	25693804
ADDA_HUMAN	ADD1	physical	25693804
ELYS_HUMAN	AHCTF1	physical	25693804
ASCC3_HUMAN	ASCC3	physical	25693804
BAZ1B_HUMAN	BAZ1B	physical	25693804
BAZ2A_HUMAN	BAZ2A	physical	25693804
BOP1_HUMAN	BOP1	physical	25693804
BYST_HUMAN	BYSL	physical	25693804
CBX1_HUMAN	CBX1	physical	25693804
CBX3_HUMAN	CBX3	physical	25693804
CEBPZ_HUMAN	CEBPZ	physical	25693804
CE170_HUMAN	CEP170	physical	25693804
DDX18_HUMAN	DDX18	physical	25693804
DDX24_HUMAN	DDX24	physical	25693804
DDX27_HUMAN	DDX27	physical	25693804
DDX47_HUMAN	DDX47	physical	25693804
DHX30_HUMAN	DHX30	physical	25693804
DKC1_HUMAN	DKC1	physical	25693804
EDC4_HUMAN	EDC4	physical	25693804
EXOSX_HUMAN	EXOSC10	physical	25693804
EXOS4_HUMAN	EXOSC4	physical	25693804
FLII_HUMAN	FLII	physical	25693804
FXR1_HUMAN	FXR1	physical	25693804
PAEP_HUMAN	PAEP	physical	25693804
GLYR1_HUMAN	GLYR1	physical	25693804
GNL3_HUMAN	GNL3	physical	25693804
NOG1_HUMAN	GTPBP4	physical	25693804
H10_HUMAN	H1F0	physical	25693804
HEAT1_HUMAN	HEATR1	physical	25693804
HELZ2_HUMAN	HELZ2	physical	25693804
1A02_HUMAN	HLA-A	physical	25693804
1A03_HUMAN	HLA-A	physical	25693804
1A01_HUMAN	HLA-A	physical	25693804
1A26_HUMAN	HLA-A	physical	25693804
1C07_HUMAN	HLA-C	physical	25693804
HP1B3_HUMAN	HP1BP3	physical	25693804
HUWE1_HUMAN	HUWE1	physical	25693804
INF2_HUMAN	INF2	physical	25693804
KIF23_HUMAN	KIF23	physical	25693804
KRI1_HUMAN	KRI1	physical	25693804
LARP7_HUMAN	LARP7	physical	25693804
LAS1L_HUMAN	LAS1L	physical	25693804
LEG7_HUMAN	LGALS7	physical	25693804
LRRF1_HUMAN	LRRFIP1	physical	25693804
LRRF2_HUMAN	LRRFIP2	physical	25693804
LZTR1_HUMAN	LZTR1	physical	25693804
MK03_HUMAN	MAPK3	physical	25693804
KI67_HUMAN	MKI67	physical	25693804
MK67I_HUMAN	NIFK	physical	25693804
MRT4_HUMAN	MRTO4	physical	25693804
NAT10_HUMAN	NAT10	physical	25693804
NHP2_HUMAN	NHP2	physical	25693804
NMNA1_HUMAN	NMNAT1	physical	25693804
NOC2L_HUMAN	NOC2L	physical	25693804
NOL10_HUMAN	NOL10	physical	25693804
NOL11_HUMAN	NOL11	physical	25693804
NOL6_HUMAN	NOL6	physical	25693804
NUMA1_HUMAN	NUMA1	physical	25693804
NU153_HUMAN	NUP153	physical	25693804
NVL_HUMAN	NVL	physical	25693804
NXF1_HUMAN	NXF1	physical	25693804
OSBL8_HUMAN	OSBPL8	physical	25693804
PAF1_HUMAN	PAF1	physical	25693804
PB1_HUMAN	PBRM1	physical	25693804
RRP5_HUMAN	PDCD11	physical	25693804
PDC6I_HUMAN	PDCD6IP	physical	25693804
PELP1_HUMAN	PELP1	physical	25693804
PHIP_HUMAN	PHIP	physical	25693804
PDIP3_HUMAN	POLDIP3	physical	25693804
RPB1_HUMAN	POLR2A	physical	25693804
RPB2_HUMAN	POLR2B	physical	25693804
POP1_HUMAN	POP1	physical	25693804
KAP0_HUMAN	PRKAR1A	physical	25693804
PRKRA_HUMAN	PRKRA	physical	25693804
PRC2A_HUMAN	PRRC2A	physical	25693804
PWP1_HUMAN	PWP1	physical	25693804
RBM19_HUMAN	RBM19	physical	25693804
RBM28_HUMAN	RBM28	physical	25693804
RBM34_HUMAN	RBM34	physical	25693804
RRP12_HUMAN	RRP12	physical	25693804
RRP1B_HUMAN	RRP1B	physical	25693804
SDCB1_HUMAN	SDCBP	physical	25693804
SK2L2_HUMAN	SKIV2L2	physical	25693804
SMCA1_HUMAN	SMARCA1	physical	25693804
SMCA5_HUMAN	SMARCA5	physical	25693804
SMRC2_HUMAN	SMARCC2	physical	25693804
SNR27_HUMAN	SNRNP27	physical	25693804
SNX6_HUMAN	SNX6	physical	25693804
SON_HUMAN	SON	physical	25693804
SP100_HUMAN	SP100	physical	25693804
SPS2L_HUMAN	SPATS2L	physical	25693804
SQSTM_HUMAN	SQSTM1	physical	25693804
SRP72_HUMAN	SRP72	physical	25693804
STAU1_HUMAN	STAU1	physical	25693804
SUN1_HUMAN	SUN1	physical	25693804
SVIL_HUMAN	SVIL	physical	25693804
TBL3_HUMAN	TBL3	physical	25693804
TEX10_HUMAN	TEX10	physical	25693804
ZO1_HUMAN	TJP1	physical	25693804
TB182_HUMAN	TNKS1BP1	physical	25693804
TOP2A_HUMAN	TOP2A	physical	25693804
TRI26_HUMAN	TRIM26	physical	25693804
UBP7_HUMAN	USP7	physical	25693804
UTP6_HUMAN	UTP6	physical	25693804
WDR36_HUMAN	WDR36	physical	25693804
NSD2_HUMAN	WHSC1	physical	25693804
ZN512_HUMAN	ZNF512	physical	25693804
AAAS_HUMAN	AAAS	physical	25693804
AATF_HUMAN	AATF	physical	25693804
ABC3C_HUMAN	APOBEC3C	physical	25693804
ATAD2_HUMAN	ATAD2	physical	25693804
BRX1_HUMAN	BRIX1	physical	25693804
BTF3_HUMAN	BTF3	physical	25693804
CCD86_HUMAN	CCDC86	physical	25693804
CDC42_HUMAN	CDC42	physical	25693804
UTP4_HUMAN	CIRH1A	physical	25693804
CKAP5_HUMAN	CKAP5	physical	25693804
CSK22_HUMAN	CSNK2A2	physical	25693804
CSK2B_HUMAN	CSNK2B	physical	25693804
CUL4A_HUMAN	CUL4A	physical	25693804
DBP_HUMAN	DBP	physical	25693804
DCA13_HUMAN	DCAF13	physical	25693804
DDX28_HUMAN	DDX28	physical	25693804
DDX51_HUMAN	DDX51	physical	25693804
DDX52_HUMAN	DDX52	physical	25693804
DDX56_HUMAN	DDX56	physical	25693804
DDX6L_HUMAN	DDX60L	physical	25693804
DJC10_HUMAN	DNAJC10	physical	25693804
TDIF2_HUMAN	DNTTIP2	physical	25693804
DOCK7_HUMAN	DOCK7	physical	25693804
DYL1_HUMAN	DYNLL1	physical	25693804
E2AK2_HUMAN	EIF2AK2	physical	25693804
EIF3K_HUMAN	EIF3K	physical	25693804
EXOS6_HUMAN	EXOSC6	physical	25693804
FGF2_HUMAN	FGF2	physical	25693804
FHL2_HUMAN	FHL2	physical	25693804
SPB1_HUMAN	FTSJ3	physical	25693804
FXR2_HUMAN	FXR2	physical	25693804
GLE1_HUMAN	GLE1	physical	25693804
GRWD1_HUMAN	GRWD1	physical	25693804
GSDMA_HUMAN	GSDMA	physical	25693804
IFIT2_HUMAN	IFIT2	physical	25693804
IMP4_HUMAN	IMP4	physical	25693804
IPO7_HUMAN	IPO7	physical	25693804
PUM3_HUMAN	KIAA0020	physical	25693804
LEMD2_HUMAN	LEMD2	physical	25693804
GANP_HUMAN	MCM3AP	physical	25693804
MPP10_HUMAN	MPHOSPH10	physical	25693804
NDC1_HUMAN	NDC1	physical	25693804
NGDN_HUMAN	NGDN	physical	25693804
NKRF_HUMAN	NKRF	physical	25693804
NLE1_HUMAN	NLE1	physical	25693804
NOC4L_HUMAN	NOC4L	physical	25693804
NOP16_HUMAN	NOP16	physical	25693804
NSA2_HUMAN	NSA2	physical	25693804
NU133_HUMAN	NUP133	physical	25693804
NU188_HUMAN	NUP188	physical	25693804
NU205_HUMAN	NUP205	physical	25693804
NU214_HUMAN	NUP214	physical	25693804
NUP37_HUMAN	NUP37	physical	25693804
NUP62_HUMAN	NUP62	physical	25693804
NUP85_HUMAN	NUP85	physical	25693804
NUP88_HUMAN	NUP88	physical	25693804
NUP93_HUMAN	NUP93	physical	25693804
NUP98_HUMAN	NUP98	physical	25693804
HAP28_HUMAN	PDAP1	physical	25693804
PLRG1_HUMAN	PLRG1	physical	25693804
PML_HUMAN	PML	physical	25693804
PPHLN_HUMAN	PPHLN1	physical	25693804
PP2AB_HUMAN	PPP2CB	physical	25693804
PR40A_HUMAN	PRPF40A	physical	25693804
PSPC1_HUMAN	PSPC1	physical	25693804
HACD3_HUMAN	PTPLAD1	physical	25693804
PWP2_HUMAN	PWP2	physical	25693804
RAB14_HUMAN	RAB14	physical	25693804
RAE1L_HUMAN	RAE1	physical	25693804
RCL1_HUMAN	RCL1	physical	25693804
RGPD8_HUMAN	RGPD8	physical	25693804
RN213_HUMAN	RNF213	physical	25693804
RPF2_HUMAN	RPF2	physical	25693804
RPP30_HUMAN	RPP30	physical	25693804
U3IP2_HUMAN	RRP9	physical	25693804
RLP24_HUMAN	RSL24D1	physical	25693804
SAP18_HUMAN	SAP18	physical	25693804
SEH1_HUMAN	SEH1L	physical	25693804
SMHD1_HUMAN	SMCHD1	physical	25693804
SSRP1_HUMAN	SSRP1	physical	25693804
SUMO1_HUMAN	SUMO1	physical	25693804
SUN2_HUMAN	SUN2	physical	25693804
SYNE1_HUMAN	SYNE1	physical	25693804
TKT_HUMAN	TKT	physical	25693804
TMM43_HUMAN	TMEM43	physical	25693804
NPA1P_HUMAN	URB1	physical	25693804
UTP15_HUMAN	UTP15	physical	25693804
UTP18_HUMAN	UTP18	physical	25693804
WDR12_HUMAN	WDR12	physical	25693804
WDR3_HUMAN	WDR3	physical	25693804
WDR43_HUMAN	WDR43	physical	25693804
WDR46_HUMAN	WDR46	physical	25693804
WDR75_HUMAN	WDR75	physical	25693804
FL2D_HUMAN	WTAP	physical	25693804
TFG_HUMAN	TFG	physical	25693804
NCBP3_HUMAN	C17orf85	physical	25693804
CH033_HUMAN	C8orf33	physical	25693804
TLDC1_HUMAN	TLDC1	physical	25693804
SPAS2_HUMAN	SPATS2	physical	25693804
ZCHC3_HUMAN	ZCCHC3	physical	25693804
RGPD3_HUMAN	RGPD3	physical	25693804
LSM12_HUMAN	LSM12	physical	25693804
TM209_HUMAN	TMEM209	physical	25693804
AGO2_HUMAN	AGO2	physical	25693804
ABC3B_HUMAN	APOBEC3B	physical	25693804
BMS1_HUMAN	BMS1	physical	25693804
BRD1_HUMAN	BRD1	physical	25693804
CARM1_HUMAN	CARM1	physical	25693804
CBX5_HUMAN	CBX5	physical	25693804
CC137_HUMAN	CCDC137	physical	25693804
CDK1_HUMAN	CDK1	physical	25693804
CENPB_HUMAN	CENPB	physical	25693804
CENPV_HUMAN	CENPV	physical	25693804
CNOT1_HUMAN	CNOT1	physical	25693804
COIL_HUMAN	COIL	physical	25693804
CRNL1_HUMAN	CRNKL1	physical	25693804
CTCF_HUMAN	CTCF	physical	25693804
CTND1_HUMAN	CTNND1	physical	25693804
DDX10_HUMAN	DDX10	physical	25693804
DDX54_HUMAN	DDX54	physical	25693804
DHX16_HUMAN	DHX16	physical	25693804
DHX29_HUMAN	DHX29	physical	25693804
DHX33_HUMAN	DHX33	physical	25693804
DHX36_HUMAN	DHX36	physical	25693804
DHX57_HUMAN	DHX57	physical	25693804
DHX8_HUMAN	DHX8	physical	25693804
EBP2_HUMAN	EBNA1BP2	physical	25693804
IF6_HUMAN	EIF6	physical	25693804
NEP1_HUMAN	EMG1	physical	25693804
ESF1_HUMAN	ESF1	physical	25693804
EXOS2_HUMAN	EXOSC2	physical	25693804
EXOS3_HUMAN	EXOSC3	physical	25693804
EXOS7_HUMAN	EXOSC7	physical	25693804
EXOS8_HUMAN	EXOSC8	physical	25693804
TASOR_HUMAN	FAM208A	physical	25693804
FBW1B_HUMAN	FBXW11	physical	25693804
FCF1_HUMAN	FCF1	physical	25693804
FMR1_HUMAN	FMR1	physical	25693804
NOG2_HUMAN	GNL2	physical	25693804
H2AY_HUMAN	H2AFY	physical	25693804
H2AW_HUMAN	H2AFY2	physical	25693804
INCE_HUMAN	INCENP	physical	25693804
KAT7_HUMAN	KAT7	physical	25693804
KHDR3_HUMAN	KHDRBS3	physical	25693804
KRR1_HUMAN	KRR1	physical	25693804
LARP1_HUMAN	LARP1	physical	25693804
LAR4B_HUMAN	LARP4B	physical	25693804
LYAR_HUMAN	LYAR	physical	25693804
MAK16_HUMAN	MAK16	physical	25693804
MBD2_HUMAN	MBD2	physical	25693804
MPP8_HUMAN	MPHOSPH8	physical	25693804
NCBP1_HUMAN	NCBP1	physical	25693804
NH2L1_HUMAN	NHP2L1	physical	25693804
NOC3L_HUMAN	NOC3L	physical	25693804
NOL9_HUMAN	NOL9	physical	25693804
NU107_HUMAN	NUP107	physical	25693804
NU160_HUMAN	NUP160	physical	25693804
NUP53_HUMAN	NUP35	physical	25693804
NUP43_HUMAN	NUP43	physical	25693804
NUP50_HUMAN	NUP50	physical	25693804
NUP54_HUMAN	NUP54	physical	25693804
NUP58_HUMAN	NUPL1	physical	25693804
PK1IP_HUMAN	PAK1IP1	physical	25693804
PCID2_HUMAN	PCID2	physical	25693804
PESC_HUMAN	PES1	physical	25693804
PHF14_HUMAN	PHF14	physical	25693804
PI42A_HUMAN	PIP4K2A	physical	25693804
PININ_HUMAN	PNN	physical	25693804
RPP29_HUMAN	POP4	physical	25693804
SSF1_HUMAN	PPAN	physical	25693804
PR38A_HUMAN	PRPF38A	physical	25693804
RGAP1_HUMAN	RACGAP1	physical	25693804
RBM14_HUMAN	RBM14	physical	25693804
RBM15_HUMAN	RBM15	physical	25693804
RBM25_HUMAN	RBM25	physical	25693804
RBM8A_HUMAN	RBM8A	physical	25693804
REXO4_HUMAN	REXO4	physical	25693804
RFC2_HUMAN	RFC2	physical	25693804
RFC3_HUMAN	RFC3	physical	25693804
RPF1_HUMAN	RPF1	physical	25693804
RL36A_HUMAN	RPL36A	physical	25693804
RRP1_HUMAN	RRP1	physical	25693804
RRP8_HUMAN	RRP8	physical	25693804
RRS1_HUMAN	RRS1	physical	25693804
SNUT1_HUMAN	SART1	physical	25693804
SART3_HUMAN	SART3	physical	25693804
SEC13_HUMAN	SEC13	physical	25693804
SENP3_HUMAN	SENP3	physical	25693804
SMU1_HUMAN	SMU1	physical	25693804
SRP68_HUMAN	SRP68	physical	25693804
SRPK1_HUMAN	SRPK1	physical	25693804
SRRM1_HUMAN	SRRM1	physical	25693804
SSFA2_HUMAN	SSFA2	physical	25693804
STK3_HUMAN	STK3	physical	25693804
SP16H_HUMAN	SUPT16H	physical	25693804
SPT5H_HUMAN	SUPT5H	physical	25693804
ELOC_HUMAN	TCEB1	physical	25693804
TOP2B_HUMAN	TOP2B	physical	25693804
TOIP1_HUMAN	TOR1AIP1	physical	25693804
TRI56_HUMAN	TRIM56	physical	25693804
TRIPC_HUMAN	TRIP12	physical	25693804
TSR1_HUMAN	TSR1	physical	25693804
UACA_HUMAN	UACA	physical	25693804
UBF1_HUMAN	UBTF	physical	25693804
RENT1_HUMAN	UPF1	physical	25693804
URB2_HUMAN	URB2	physical	25693804
UBP36_HUMAN	USP36	physical	25693804
UTP11_HUMAN	UTP11L	physical	25693804
UT14A_HUMAN	UTP14A	physical	25693804
UTP20_HUMAN	UTP20	physical	25693804
SAS10_HUMAN	UTP3	physical	25693804
WDR18_HUMAN	WDR18	physical	25693804
WDR61_HUMAN	WDR61	physical	25693804
WDR74_HUMAN	WDR74	physical	25693804
SYF1_HUMAN	XAB2	physical	25693804
XRN1_HUMAN	XRN1	physical	25693804
YTDC1_HUMAN	YTHDC1	physical	25693804
YTDC2_HUMAN	YTHDC2	physical	25693804
ZC3HE_HUMAN	ZC3H14	physical	25693804
ZCCHV_HUMAN	ZC3HAV1	physical	25693804
ZN574_HUMAN	ZNF574	physical	25693804
ZN579_HUMAN	ZNF579	physical	25693804
ZN638_HUMAN	ZNF638	physical	25693804
NEC1_HHV11	UL31	physical	25693804
ITP_HHV11	UL37	physical	25693804
TRX1_HHV11	UL38	physical	25693804
PAP_HHV11	UL42	physical	25693804
TEG1_HHV11	UL46	physical	25693804
TEG5_HHV11	UL47	physical	25693804
GB_HHV11	UL27	physical	25693804
GH_HHV11	UL22	physical	25693804
GL_HHV11	UL1	physical	25693804
GM_HHV11	UL10	physical	25693804
AN_HHV11	UL12	physical	25693804
UL13_HHV11	UL13	physical	25693804
TEG3_HHV11	UL14	physical	25693804
CVC1_HHV11	UL17	physical	25693804
TEG4_HHV11	UL21	physical	25693804
UL24_HHV11	UL24	physical	25693804
CVC2_HHV11	UL25	physical	25693804
LTP_HHV11	UL36	physical	25693804
RIR1_HHV11	UL39	physical	25693804
RIR2_HHV11	UL40	physical	25693804
SHUT_HHV11	UL41	physical	25693804
VP16_HHV11	UL48	physical	25693804
DUT_HHV11	UL50	physical	25693804
TEG7_HHV11	UL51	physical	25693804
ICP27_HHV11	UL54	physical	25693804
UL56_HHV11	UL56	physical	25693804
CEP1_HHV11	UL7	physical	25693804
MCP_HHV11	UL19	physical	25693804
SCAF_HHV11	UL26	physical	25693804
DPOL_HHV11	UL30	physical	25693804
HELI_HHV11	UL5	physical	25693804
PORTL_HHV11	UL6	physical	25693804
ICP22_HHV11	US1	physical	25693804
RNB_HHV11	US11	physical	25693804
US02_HHV11	US2	physical	25693804
US03_HHV11	US3	physical	25693804
GG_HHV11	US3	physical	25693804
ICP0_HHV11	RL2	physical	25693804
ICP4_HHV11	RS1	physical	25693804
DNBI_HHV11	UL29	physical	25693804
BRCA1_HUMAN	BRCA1	physical	26121674
ASC_HUMAN	PYCARD	physical	26121674
CASP1_HUMAN	CASP1	physical	26121674
STING_HUMAN	TMEM173	physical	26121674

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-214, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153, ANDMASS SPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106 AND SER-153, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.
PubMed: 18187866

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.
PubMed: 16964243

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153, AND MASSSPECTROMETRY.
PubMed: 15302935