GH_HHV11 - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GH_HHV11
• UniProt AC: P06477
• Protein Name: Envelope glycoprotein H {ECO:0000255|HAMAP-Rule:MF_04033}
• Gene Name: gH {ECO:0000255|HAMAP-Rule:MF_04033}
• Organism: Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
• Sequence Length: 838
• Subcellular Localization: Virion membrane ; Single-pass type I membrane protein . Host cell membrane ; Single-pass type I membrane protein . Host endosome membrane ; Single-pass type I membrane protein . During virion morphogenesis, this protein probably accumulates in the en
• Protein Description: The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis..
• Protein Sequence: MGNGLWFVGVIILGVAWGQVHDWTEQTDPWFLDGLGMDRMYWRDTNTGRLWLPNTPDPQKPPRGFLAPPDELNLTTASLPLLRWYEERFCFVLVTTAEFPRDPGQLLYIPKTYLLGRPPNASLPAPTTVEPTAQPPPSVAPLKGLLHNPAASVLLRSRAWVTFSAVPDPEALTFPRGDNVATASHPSGPRDTPPPRPPVGARRHPTTELDITHLHNASTTWLATRGLLRSPGRYVYFSPSASTWPVGIWTTGELVLGCDAALVRARYGREFMGLVISMHDSPPVEVMVVPAGQTLDRVGDPADENPPGALPGPPGGPRYRVFVLGSLTRADNGSALDALRRVGGYPEEGTNYAQFLSRAYAEFFSGDAGAEQGPRPPLFWRLTGLLATSGFAFVNAAHANGAVCLSDLLGFLAHSRALAGLAARGAAGCAADSVFFNVSVLDPTARLQLEARLQHLVAEILEREQSLALHALGYQLAFVLDSPSAYDAVAPSAAHLIDALYAEFLGGRVLTTPVVHRALFYASAVLRQPFLAGVPSAVQRERARRSLLIASALCTSDVAAATNADLRTALARADHQKTLFWLPDHFSPCAASLRFDLDESVFILDALAQATRSETPVEVLAQQTHGLASTLTRWAHYNALIRAFVPEASHRCGGQSANVEPRILVPITHNASYVVTHSPLPRGIGYKLTGVDVRRPLFLTYLTATCEGSTRDIESKRLVRTQNQRDLGLVGAVFMRYTPAGEVMSVLLVDTDNTQQQIAAGPTEGAPSVFSSDVPSTALLLFPNGTVIHLLAFDTQPVAAIAPGFLAASALGVVMITAALAGILKVLRTSVPFFWRRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	N-linked_Glycosylation	LAPPDELNLTTASLP CCCHHHCCCCCCCCH	33.04	UniProtKB CARBOHYD
120	N-linked_Glycosylation	YLLGRPPNASLPAPT EECCCCCCCCCCCCC	44.86	UniProtKB CARBOHYD
216	N-linked_Glycosylation	LDITHLHNASTTWLA EECEEECCCCHHHHE	41.78	UniProtKB CARBOHYD
332	N-linked_Glycosylation	GSLTRADNGSALDAL ECCEECCCCCHHHHH	45.38	UniProtKB CARBOHYD
437	N-linked_Glycosylation	AADSVFFNVSVLDPT CCCCEEEEHHCCCCC	17.43	UniProtKB CARBOHYD
670	N-linked_Glycosylation	ILVPITHNASYVVTH EEEEECCCCCEEEEC	23.18	UniProtKB CARBOHYD
784	N-linked_Glycosylation	TALLLFPNGTVIHLL CEEEECCCCEEEEEE	51.97	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GH_HHV11 !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GH_HHV11 !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GH_HHV11 !!

Protein-Protein Interaction

Oops, there are no PPI records of GH_HHV11 !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.