FCF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCF1_HUMAN
• UniProt AC: Q9Y324
• Protein Name: rRNA-processing protein FCF1 homolog
• Gene Name: FCF1
• Organism: Homo sapiens (Human).
• Sequence Length: 198
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly..
• Protein Sequence: MGKQKKTRKYATMKRMLSLRDQRLKEKDRLKPKKKEKKDPSALKEREVPQHPSCLFFQYNTQLGPPYHILVDTNFINFSIKAKLDLVQSMMDCLYAKCIPCITDCVMAEIEKLGQKYRVALRIAKDPRFERLPCTHKGTYADDCLVQRVTQHKCYIVATVDRDLKRRIRKIPGVPIMYISNHRYNIERMPDDYGAPRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	KQKKTRKYATMKRML CCHHHHHHHHHHHHH	12.19	24719451
12	Phosphorylation	KKTRKYATMKRMLSL HHHHHHHHHHHHHHH	21.82	24719451
18	Phosphorylation	ATMKRMLSLRDQRLK HHHHHHHHHHHHHHH	16.41	21712546
83	Acetylation	INFSIKAKLDLVQSM CCCCHHHHHHHHHHH	37.22	26051181
137	Ubiquitination	ERLPCTHKGTYADDC CCCCCCCCCCCCCCC	34.49	-
137	Acetylation	ERLPCTHKGTYADDC CCCCCCCCCCCCCCC	34.49	25953088
153	Ubiquitination	VQRVTQHKCYIVATV HHHHHCCCCEEEEEE	20.93	-
178	Phosphorylation	IPGVPIMYISNHRYN CCCCCEEEEECCCCC	11.25	-
193	Phosphorylation	IERMPDDYGAPRF-- CCCCCCCCCCCCC--	23.67	23532336
197	Methylation	PDDYGAPRF------ CCCCCCCCC------	49.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEPL_HUMAN	PPL	physical	28514442
TREX2_HUMAN	TREX2	physical	28514442
ST2B1_HUMAN	SULT2B1	physical	28514442
ENDOU_HUMAN	ENDOU	physical	28514442
EVPL_HUMAN	EVPL	physical	28514442
INVO_HUMAN	IVL	physical	28514442
SPB5_HUMAN	SERPINB5	physical	28514442
TRI29_HUMAN	TRIM29	physical	28514442
SPA12_HUMAN	SERPINA12	physical	28514442
MAOX_HUMAN	ME1	physical	28514442
KLK7_HUMAN	KLK7	physical	28514442
LEGL_HUMAN	LGALSL	physical	28514442
RAB5B_HUMAN	RAB5B	physical	28514442
IL1RA_HUMAN	IL1RN	physical	28514442
OTU1_HUMAN	YOD1	physical	28514442
CALL5_HUMAN	CALML5	physical	28514442
PKP3_HUMAN	PKP3	physical	28514442
DMKN_HUMAN	DMKN	physical	28514442
ASC_HUMAN	PYCARD	physical	28514442
SPB8_HUMAN	SERPINB8	physical	28514442
DR9C7_HUMAN	SDR9C7	physical	28514442
KLK10_HUMAN	KLK10	physical	28514442
FILA_HUMAN	FLG	physical	28514442
POF1B_HUMAN	POF1B	physical	28514442
HUTH_HUMAN	HAL	physical	28514442
PAI2_HUMAN	SERPINB2	physical	28514442
RABP2_HUMAN	CRABP2	physical	28514442
EPIPL_HUMAN	EPPK1	physical	28514442
APRV1_HUMAN	ASPRV1	physical	28514442
RNAS7_HUMAN	RNASE7	physical	28514442
KPRP_HUMAN	KPRP	physical	28514442
SBSN_HUMAN	SBSN	physical	28514442
FBX50_HUMAN	NCCRP1	physical	28514442
CRYAB_HUMAN	CRYAB	physical	28514442
MYH14_HUMAN	MYH14	physical	28514442
NFH_HUMAN	NEFH	physical	28514442
LYPA1_HUMAN	LYPLA1	physical	28514442
PPAP_HUMAN	ACPP	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442
ARGI1_HUMAN	ARG1	physical	28514442
PKP1_HUMAN	PKP1	physical	28514442
CASPE_HUMAN	CASP14	physical	28514442
CYTM_HUMAN	CST6	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.