LEGL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LEGL_HUMAN
• UniProt AC: Q3ZCW2
• Protein Name: Galectin-related protein
• Gene Name: LGALSL
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Protein Description: Does not bind lactose, and may not bind carbohydrates..
• Protein Sequence: MAGSVADSDAVVKLDDGHLNNSLSSPVQADVYFPRLIVPFCGHIKGGMRPGKKVLVMGIVDLNPESFAISLTCGDSEDPPADVAIELKAVFTDRQLLRNSCISGERGEEQSAIPYFPFIPDQPFRVEILCEHPRFRVFVDGHQLFDFYHRIQTLSAIDTIKINGDLQITKLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSVADSD ------CCCCCCCCC	20.97	19413330
4	Phosphorylation	----MAGSVADSDAV ----CCCCCCCCCCE	12.47	27732954
8	Phosphorylation	MAGSVADSDAVVKLD CCCCCCCCCCEEECC	20.10	28450419
22	Phosphorylation	DDGHLNNSLSSPVQA CCCCCCCCCCCCCCC	28.67	30266825
24	Phosphorylation	GHLNNSLSSPVQADV CCCCCCCCCCCCCCE	32.20	30266825
25	Phosphorylation	HLNNSLSSPVQADVY CCCCCCCCCCCCCEE	34.09	29255136
32	Phosphorylation	SPVQADVYFPRLIVP CCCCCCEEECCEECC	14.38	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LEGL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LEGL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LEGL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LEGL_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22 AND SER-25, AND MASSSPECTROMETRY.
PubMed: 18669648