KLK10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK10_HUMAN
• UniProt AC: O43240
• Protein Name: Kallikrein-10
• Gene Name: KLK10
• Organism: Homo sapiens (Human).
• Sequence Length: 276
• Subcellular Localization: Secreted .
• Protein Description: Has a tumor-suppressor role for NES1 in breast and prostate cancer..
• Protein Sequence: MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	N-linked_Glycosylation	EAALLPQNDTRLDPE HHHHCCCCCCCCCHH	51.16	UniProtKB CARBOHYD
125	Phosphorylation	HPKYHQGSGPILPRR CCCCCCCCCCCCCCC	34.52	21299198
194	Phosphorylation	GLTCSSITILSPKEC CCCEEEEEEECCCCC	20.15	-
197	Phosphorylation	CSSITILSPKECEVF EEEEEEECCCCCEEE	30.03	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRIF1_HUMAN	LRIF1	physical	16169070
EDC3_HUMAN	EDC3	physical	26186194
O6C70_HUMAN	OR6C70	physical	26186194
EDC3_HUMAN	EDC3	physical	28514442
O6C70_HUMAN	OR6C70	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.