SPB8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPB8_HUMAN
• UniProt AC: P50452
• Protein Name: Serpin B8
• Gene Name: SERPINB8
• Organism: Homo sapiens (Human).
• Sequence Length: 374
• Subcellular Localization: Cytoplasm.
• Protein Description: Has an important role in epithelial desmosome-mediated cell-cell adhesion..
• Protein Sequence: MDDLCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFMGAKGSTAAQMSQALCLYKDGDIHRGFQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLPDFKEYCQKFYQAELEELSFAEDTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLVLVNAIYFKGKWNEQFDRKYTRGMLFKTNEEKKTVQMMFKEAKFKMGYADEVHTQVLELPYVEEELSMVILLPDDNTDLAVVEKALTYEKFKAWTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRMEPRFCADHPFLFFIRHHKTNCILFCGRFSSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	ANGTFAISLFKILGE HCCEEEEEEEHHHCC	25.07	24719451
31	Phosphorylation	NSRNVFFSPMSISSA CCCCCCCCCCCHHHH	14.29	25072903
34	Phosphorylation	NVFFSPMSISSALAM CCCCCCCCHHHHHHH	23.78	25072903
36	Phosphorylation	FFSPMSISSALAMVF CCCCCCHHHHHHHHH	11.40	25072903
37	Phosphorylation	FSPMSISSALAMVFM CCCCCHHHHHHHHHC	26.15	25072903
49	Phosphorylation	VFMGAKGSTAAQMSQ HHCCCCCCHHHHHHH	17.73	25072903
50	Phosphorylation	FMGAKGSTAAQMSQA HCCCCCCHHHHHHHH	34.38	28857561
55	Phosphorylation	GSTAAQMSQALCLYK CCHHHHHHHHHHHHC	10.54	25072903
61	Phosphorylation	MSQALCLYKDGDIHR HHHHHHHHCCCCHHH	13.16	23532336
75	Phosphorylation	RGFQSLLSEVNRTGT HHHHHHHHHHHHHHH	44.80	-
76	Ubiquitination	GFQSLLSEVNRTGTQ HHHHHHHHHHHHHHH	43.72	-
80	Phosphorylation	LLSEVNRTGTQYLLR HHHHHHHHHHHHHHH	39.10	-
81	Ubiquitination	LSEVNRTGTQYLLRT HHHHHHHHHHHHHHH	13.95	-
84	Phosphorylation	VNRTGTQYLLRTANR HHHHHHHHHHHHHHH	13.93	28152594
87	Methylation	TGTQYLLRTANRLFG HHHHHHHHHHHHHHC	29.24	-
90	Ubiquitination	QYLLRTANRLFGEKT HHHHHHHHHHHCCCC	40.34	-
96	Ubiquitination	ANRLFGEKTCDFLPD HHHHHCCCCCCCCCC	55.63	-
105	Ubiquitination	CDFLPDFKEYCQKFY CCCCCCHHHHHHHHH	55.97	-
114	Ubiquitination	YCQKFYQAELEELSF HHHHHHHHHHHHCCC	16.38	-
124	Ubiquitination	EELSFAEDTEECRKH HHCCCCCCHHHHHHH	56.86	-
130	Ubiquitination	EDTEECRKHINDWVA CCHHHHHHHHHHHHH	61.57	-
130	Ubiquitination	EDTEECRKHINDWVA CCHHHHHHHHHHHHH	61.57	-
134	Ubiquitination	ECRKHINDWVAEKTE HHHHHHHHHHHHHCC	40.39	-
139	Ubiquitination	INDWVAEKTEGKISE HHHHHHHHCCCCHHH	41.98	-
143	Ubiquitination	VAEKTEGKISEVLDA HHHHCCCCHHHHHCC	36.51	-
166	Phosphorylation	LVLVNAIYFKGKWNE HHEEEEEEECCCCHH	9.23	27259358
170	Ubiquitination	NAIYFKGKWNEQFDR EEEEECCCCHHHHCH	47.65	-
178	Methylation	WNEQFDRKYTRGMLF CHHHHCHHHHCCCEE	53.47	19816173
178	Acetylation	WNEQFDRKYTRGMLF CHHHHCHHHHCCCEE	53.47	19816173
179	Phosphorylation	NEQFDRKYTRGMLFK HHHHCHHHHCCCEEE	11.54	19702290
186	Ubiquitination	YTRGMLFKTNEEKKT HHCCCEEECCCHHHH	46.62	-
191	Ubiquitination	LFKTNEEKKTVQMMF EEECCCHHHHHHHHH	47.79	-
193	Phosphorylation	KTNEEKKTVQMMFKE ECCCHHHHHHHHHHH	27.34	24114839
249	Ubiquitination	EKALTYEKFKAWTNS HHHHHHHHHHHHCCC	41.57	-
251	Ubiquitination	ALTYEKFKAWTNSEK HHHHHHHHHHCCCHH	54.83	-
258	Ubiquitination	KAWTNSEKLTKSKVQ HHHCCCHHCCHHHHE	62.37	-
262	Phosphorylation	NSEKLTKSKVQVFLP CCHHCCHHHHEEEHH	32.59	-
263	Ubiquitination	SEKLTKSKVQVFLPR CHHCCHHHHEEEHHH	37.94	-
263	Malonylation	SEKLTKSKVQVFLPR CHHCCHHHHEEEHHH	37.94	26320211
272	Ubiquitination	QVFLPRLKLEESYDL EEEHHHCCCCCCCCC	55.95	-
296	Ubiquitination	IDAFDEAKADFSGMS HHHCHHHCCCCCCCC	46.57	21906983
302	Sulfoxidation	AKADFSGMSTEKNVP HCCCCCCCCCCCCCC	4.31	30846556
306	Ubiquitination	FSGMSTEKNVPLSKV CCCCCCCCCCCHHHH	64.43	-
312	Ubiquitination	EKNVPLSKVAHKCFV CCCCCHHHHHHEEEE	51.64	-
316	Ubiquitination	PLSKVAHKCFVEVNE CHHHHHHEEEEEECC	21.45	-
338	Phosphorylation	ATAVVRNSRCSRMEP HHHHHHCCCCCCCCC	24.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPB8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPB8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPB8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FURIN_HUMAN	FURIN	physical	9442015
SYLC_HUMAN	LARS	physical	22939629
CGL_HUMAN	CTH	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
NONO_HUMAN	NONO	physical	28514442
F102A_HUMAN	FAM102A	physical	28514442
TOX4_HUMAN	TOX4	physical	28514442
PXDC2_HUMAN	PLXDC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.