DMKN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DMKN_HUMAN
• UniProt AC: Q6E0U4
• Protein Name: Dermokine
• Gene Name: DMKN
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Secreted .
• Protein Description: May act as a soluble regulator of keratinocyte differentiation..
• Protein Sequence: MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGVADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYFSRLWEDFKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKTPAKGGVSPSSSASRVQPGLLQWVKFW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	GTREAVGTGVRQVPG CHHHHHCCCCCCCCC	26.38	29978859
109	O-linked_Glycosylation	AAHALGNTGHEIGRQ HHHHHCCCCCHHHHH	37.81	55828497
279 (in isoform 2)	Phosphorylation	-	41.78	26699800
279 (in isoform 16)	Phosphorylation	-	41.78	26699800
300 (in isoform 16)	Phosphorylation	-	47.22	20068231
301 (in isoform 2)	Phosphorylation	-	39.92	20068231
314 (in isoform 16)	Phosphorylation	-	45.36	-
315 (in isoform 2)	Phosphorylation	-	31.91	-
319 (in isoform 16)	Phosphorylation	-	18.63	27251275
320 (in isoform 2)	Phosphorylation	-	38.57	27251275
320 (in isoform 16)	Phosphorylation	-	38.57	27251275
321 (in isoform 2)	Phosphorylation	-	51.83	27251275
323	Phosphorylation	NHGGSGGGNGHKPGC CCCCCCCCCCCCCCC	40.23	27251275
323 (in isoform 16)	Phosphorylation	-	40.23	27251275
324 (in isoform 2)	Phosphorylation	-	53.31	27251275
340 (in isoform 5)	Phosphorylation	-	33.56	26699800
340 (in isoform 6)	Phosphorylation	-	33.56	26699800
361 (in isoform 6)	Phosphorylation	-	9.22	20068231
375 (in isoform 6)	Phosphorylation	-	10.00	-
380 (in isoform 6)	Phosphorylation	-	51.18	27251275
381 (in isoform 6)	Phosphorylation	-	12.27	27251275
384 (in isoform 6)	Phosphorylation	-	42.11	27251275
403	Phosphorylation	WEDFKQNTPFLNWKA HHHHHHCCCCCCHHH	16.96	28258704
418	Phosphorylation	IIEGADASSLQKRAG HHCCCCHHHHHHHHC	31.93	28258704
419	Phosphorylation	IEGADASSLQKRAGR HCCCCHHHHHHHHCC	36.22	28258704
445	Ubiquitination	YPTAYGGKYSVKTPA CCCCCCCEEEEECCC	29.95	-
447	Phosphorylation	TAYGGKYSVKTPAKG CCCCCEEEEECCCCC	22.18	27251275
450	Phosphorylation	GGKYSVKTPAKGGVS CCEEEEECCCCCCCC	26.73	20068231
457	Phosphorylation	TPAKGGVSPSSSASR CCCCCCCCCCCCHHH	23.49	20068231
459	Phosphorylation	AKGGVSPSSSASRVQ CCCCCCCCCCHHHCC	29.44	20068231
460	Phosphorylation	KGGVSPSSSASRVQP CCCCCCCCCHHHCCC	33.05	20068231
461	Phosphorylation	GGVSPSSSASRVQPG CCCCCCCCHHHCCCC	34.30	20068231
463	Phosphorylation	VSPSSSASRVQPGLL CCCCCCHHHCCCCCC	34.63	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DMKN_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DMKN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DMKN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.