dbPTM

UBP36_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP36_HUMAN
UniProt AC	Q9P275
Protein Name	Ubiquitin carboxyl-terminal hydrolase 36 {ECO:0000305}
Gene Name	USP36 {ECO:0000312\|HGNC:HGNC:20062}
Organism	Homo sapiens (Human).
Sequence Length	1123
Subcellular Localization	Nucleus, nucleolus . Cytoplasm .
Protein Description	Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. [PubMed: 29273634]
Protein Sequence	MPIVDKLKEALKPGRKDSADDGELGKLLASSAKKVLLQKIEFEPASKSFSYQLEALKSKYVLLNPKTEGASRHKSGDDPPARRQGSEHTYESCGDGVPAPQKVLFPTERLSLRWERVFRVGAGLHNLGNTCFLNATIQCLTYTPPLANYLLSKEHARSCHQGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACLNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDVALEIRQAANIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQNNGDPVMYGLYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPEGLISRTGSSSLPGRPSVIPDHSKKNIGNGIISSPLTGKRQDSGTMKKPHTTEEIGVPISRNGSTLGLKSQNGCIPPKLPSGSPSPKLSQTPTHMPTILDDPGKKVKKPAPPQHFSPRTAQGLPGTSNSNSSRSGSQRQGSWDSRDVVLSTSPKLLATATANGHGLKGNDESAGLDRRGSSSSSPEHSASSDSTKAPQTPRSGAAHLCDSQETNCSTAGHSKTPPSGADSKTVKLKSPVLSNTTTEPASTMSPPPAKKLALSAKKASTLWRATGNDLRPPPPSPSSDLTHPMKTSHPVVASTWPVHRARAVSPAPQSSSRLQPPFSPHPTLLSSTPKPPGTSEPRSCSSISTALPQVNEDLVSLPHQLPEASEPPQSPSEKRKKTFVGEPQRLGSETRLPQHIREATAAPHGKRKRKKKKRPEDTAASALQEGQTQRQPGSPMYRREGQAQLPAVRRQEDGTQPQVNGQQVGCVTDGHHASSRKRRRKGAEGLGEEGGLHQDPLRHSCSPMGDGDPEAMEESPRKKKKKKRKQETQRAVEEDGHLKCPRSAKPQDAVVPESSSCAPSANGWCPGDRMGLSQAPPVSWNGERESDVVQELLKYSSDKAYGRKVLTWDGKMSAVSQDAIEDSRQARTETVVDDWDEEFDRGKEKKIKKFKREKRRNFNAFQKLQTRRNFWSVTHPAKAASLSYRR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Acetylation	--MPIVDKLKEALKP --CCHHHHHHHHHCC	51.03	27452117
6	Malonylation	--MPIVDKLKEALKP --CCHHHHHHHHHCC	51.03	26320211
18	Phosphorylation	LKPGRKDSADDGELG HCCCCCCCCCCCHHH	36.31	28985074
18 (in isoform 2)	Phosphorylation	-	36.31	27251275
26	Ubiquitination	ADDGELGKLLASSAK CCCCHHHHHHHHHHH	53.61	-
30	Phosphorylation	ELGKLLASSAKKVLL HHHHHHHHHHHHHHH	30.69	20860994
31	Phosphorylation	LGKLLASSAKKVLLQ HHHHHHHHHHHHHHH	38.20	29396449
33	Ubiquitination	KLLASSAKKVLLQKI HHHHHHHHHHHHHHC	45.41	-
46	Phosphorylation	KIEFEPASKSFSYQL HCCCCCCCCCHHHHH	39.28	25072903
47	Ubiquitination	IEFEPASKSFSYQLE CCCCCCCCCHHHHHH	58.59	-
48	Phosphorylation	EFEPASKSFSYQLEA CCCCCCCCHHHHHHH	19.55	25072903
50	Phosphorylation	EPASKSFSYQLEALK CCCCCCHHHHHHHHH	21.04	20860994
51	Phosphorylation	PASKSFSYQLEALKS CCCCCHHHHHHHHHC	18.33	25072903
58	Phosphorylation	YQLEALKSKYVLLNP HHHHHHHCCEEEECC	30.03	25072903
60	Phosphorylation	LEALKSKYVLLNPKT HHHHHCCEEEECCCC	11.92	20068231
66	Acetylation	KYVLLNPKTEGASRH CEEEECCCCCCHHCC	59.12	26051181
86	Phosphorylation	PPARRQGSEHTYESC CCCHHCCCCCCCCCC	20.19	28555341
89	Phosphorylation	RRQGSEHTYESCGDG HHCCCCCCCCCCCCC	25.57	25627689
102	Acetylation	DGVPAPQKVLFPTER CCCCCCCEEEECCHH	39.59	26051181
111	Phosphorylation	LFPTERLSLRWERVF EECCHHHHHCHHHHE	23.31	23532336
230	Acetylation	ACLNGCAKLDRQTQA HHHHCCHHCCHHHHH	55.80	23749302
230	Ubiquitination	ACLNGCAKLDRQTQA HHHHCCHHCCHHHHH	55.80	-
230 (in isoform 2)	Ubiquitination	-	55.80	-
268	Phosphorylation	VSDTYDPYLDVALEI CCCCCCCHHHHHHHH	16.79	28787133
295	Phosphorylation	FVKADVLSGENAYMC HHHCCHHCCCCCEEC	43.86	25404012
300	Phosphorylation	VLSGENAYMCAKCKK HHCCCCCEECHHHCC	12.33	22817900
302	S-palmitoylation	SGENAYMCAKCKKKV CCCCCEECHHHCCCC	1.82	29575903
304	Ubiquitination	ENAYMCAKCKKKVPA CCCEECHHHCCCCCC	41.48	-
316	Phosphorylation	VPASKRFTIHRTSNV CCCCCCEEEECCCCE	21.65	20068231
320	Phosphorylation	KRFTIHRTSNVLTLS CCEEEECCCCEEEEE	15.53	20068231
321	Phosphorylation	RFTIHRTSNVLTLSL CEEEECCCCEEEEEE	25.54	20068231
321 (in isoform 2)	Phosphorylation	-	25.54	-
325	Phosphorylation	HRTSNVLTLSLKRFA ECCCCEEEEEEEEHH	15.26	20068231
325 (in isoform 2)	Phosphorylation	-	15.26	-
327	Phosphorylation	TSNVLTLSLKRFANF CCCEEEEEEEEHHCC	26.98	20068231
329	Ubiquitination	NVLTLSLKRFANFSG CEEEEEEEEHHCCCC	41.94	-
329 (in isoform 2)	Ubiquitination	-	41.94	-
338	Ubiquitination	FANFSGGKITKDVGY HHCCCCCCCCCCCCC	51.21	21890473
338 (in isoform 1)	Ubiquitination	-	51.21	21890473
338 (in isoform 2)	Ubiquitination	-	51.21	21890473
341	Ubiquitination	FSGGKITKDVGYPEF CCCCCCCCCCCCCCH	54.62	-
426	Phosphorylation	FYLRIPGSKKSPEGL EEEECCCCCCCCCCC	31.40	20860994
428	Acetylation	LRIPGSKKSPEGLIS EECCCCCCCCCCCCC	73.30	26051181
428	Ubiquitination	LRIPGSKKSPEGLIS EECCCCCCCCCCCCC	73.30	-
429	Phosphorylation	RIPGSKKSPEGLISR ECCCCCCCCCCCCCC	31.74	30266825
429 (in isoform 2)	Phosphorylation	-	31.74	-
435	Phosphorylation	KSPEGLISRTGSSSL CCCCCCCCCCCCCCC	28.91	30266825
437	Phosphorylation	PEGLISRTGSSSLPG CCCCCCCCCCCCCCC	34.33	23312004
437 (in isoform 2)	Phosphorylation	-	34.33	24719451
439	Phosphorylation	GLISRTGSSSLPGRP CCCCCCCCCCCCCCC	19.01	23401153
439 (in isoform 2)	Phosphorylation	-	19.01	27251275
440	Phosphorylation	LISRTGSSSLPGRPS CCCCCCCCCCCCCCC	36.92	25159151
441	Phosphorylation	ISRTGSSSLPGRPSV CCCCCCCCCCCCCCC	40.04	23312004
447	Phosphorylation	SSLPGRPSVIPDHSK CCCCCCCCCCCCCCC	31.17	23312004
453	Phosphorylation	PSVIPDHSKKNIGNG CCCCCCCCCCCCCCC	53.34	23312004
463	Phosphorylation	NIGNGIISSPLTGKR CCCCCCCCCCCCCCC	24.79	30266825
463 (in isoform 2)	Phosphorylation	-	24.79	24719451
464	Phosphorylation	IGNGIISSPLTGKRQ CCCCCCCCCCCCCCC	17.33	30266825
464 (in isoform 2)	Phosphorylation	-	17.33	21406692
467	Phosphorylation	GIISSPLTGKRQDSG CCCCCCCCCCCCCCC	44.00	30266825
467 (in isoform 2)	Phosphorylation	-	44.00	-
469	Acetylation	ISSPLTGKRQDSGTM CCCCCCCCCCCCCCC	41.47	25953088
481	Phosphorylation	GTMKKPHTTEEIGVP CCCCCCCCCCCCCCE	44.42	27050516
482	Phosphorylation	TMKKPHTTEEIGVPI CCCCCCCCCCCCCEE	28.69	28555341
490	Phosphorylation	EEIGVPISRNGSTLG CCCCCEECCCCCCCC	17.39	28555341
494	Phosphorylation	VPISRNGSTLGLKSQ CEECCCCCCCCEECC	24.81	20860994
494 (in isoform 2)	Phosphorylation	-	24.81	21406692
495	Phosphorylation	PISRNGSTLGLKSQN EECCCCCCCCEECCC	26.66	21406692
508	"N6,N6-dimethyllysine"	QNGCIPPKLPSGSPS CCCCCCCCCCCCCCC	68.61	-
508	Methylation	QNGCIPPKLPSGSPS CCCCCCCCCCCCCCC	68.61	-
511	Phosphorylation	CIPPKLPSGSPSPKL CCCCCCCCCCCCCCC	63.44	26657352
513	Phosphorylation	PPKLPSGSPSPKLSQ CCCCCCCCCCCCCCC	26.92	30266825
513 (in isoform 2)	Phosphorylation	-	26.92	-
515	Phosphorylation	KLPSGSPSPKLSQTP CCCCCCCCCCCCCCC	36.04	30266825
515 (in isoform 2)	Phosphorylation	-	36.04	-
519	Phosphorylation	GSPSPKLSQTPTHMP CCCCCCCCCCCCCCC	37.83	28387310
521	Phosphorylation	PSPKLSQTPTHMPTI CCCCCCCCCCCCCCC	27.12	25159151
523	Phosphorylation	PKLSQTPTHMPTILD CCCCCCCCCCCCCCC	33.91	24732914
527	Phosphorylation	QTPTHMPTILDDPGK CCCCCCCCCCCCCCC	26.97	28387310
534	Acetylation	TILDDPGKKVKKPAP CCCCCCCCCCCCCCC	60.83	26051181
546	Phosphorylation	PAPPQHFSPRTAQGL CCCCCCCCCCCCCCC	16.02	30266825
546 (in isoform 2)	Phosphorylation	-	16.02	24719451
556	Phosphorylation	TAQGLPGTSNSNSSR CCCCCCCCCCCCCCC	23.85	20860994
557	Phosphorylation	AQGLPGTSNSNSSRS CCCCCCCCCCCCCCC	44.14	25627689
559	Phosphorylation	GLPGTSNSNSSRSGS CCCCCCCCCCCCCCC	37.54	25159151
561	Phosphorylation	PGTSNSNSSRSGSQR CCCCCCCCCCCCCCC	27.27	21712546
562	Phosphorylation	GTSNSNSSRSGSQRQ CCCCCCCCCCCCCCC	34.41	25627689
571	Phosphorylation	SGSQRQGSWDSRDVV CCCCCCCCCCHHHEE	21.26	28450419
574	Phosphorylation	QRQGSWDSRDVVLST CCCCCCCHHHEEEEC	24.91	23186163
580	Phosphorylation	DSRDVVLSTSPKLLA CHHHEEEECCCCCEE	18.41	22167270
580 (in isoform 2)	Phosphorylation	-	18.41	24719451
581	Phosphorylation	SRDVVLSTSPKLLAT HHHEEEECCCCCEEE	44.91	29255136
581 (in isoform 2)	Phosphorylation	-	44.91	-
582	Phosphorylation	RDVVLSTSPKLLATA HHEEEECCCCCEEEE	19.36	29255136
582 (in isoform 2)	Phosphorylation	-	19.36	27251275
584	Acetylation	VVLSTSPKLLATATA EEEECCCCCEEEECC	56.77	25953088
588	Phosphorylation	TSPKLLATATANGHG CCCCCEEEECCCCCC	25.22	26074081
590	Phosphorylation	PKLLATATANGHGLK CCCEEEECCCCCCCC	19.12	26074081
597	Acetylation	TANGHGLKGNDESAG CCCCCCCCCCCCCCC	61.33	26051181
602	Phosphorylation	GLKGNDESAGLDRRG CCCCCCCCCCCCCCC	30.42	25159151
610	Phosphorylation	AGLDRRGSSSSSPEH CCCCCCCCCCCCCCC	25.82	23927012
610 (in isoform 2)	Phosphorylation	-	25.82	24719451
611	Phosphorylation	GLDRRGSSSSSPEHS CCCCCCCCCCCCCCC	36.74	23401153
612	Phosphorylation	LDRRGSSSSSPEHSA CCCCCCCCCCCCCCC	36.21	23927012
612 (in isoform 2)	Phosphorylation	-	36.21	-
613	Phosphorylation	DRRGSSSSSPEHSAS CCCCCCCCCCCCCCC	52.43	23927012
613 (in isoform 2)	Phosphorylation	-	52.43	-
614	Phosphorylation	RRGSSSSSPEHSASS CCCCCCCCCCCCCCC	35.93	23927012
614 (in isoform 2)	Phosphorylation	-	35.93	24719451
618	Phosphorylation	SSSSPEHSASSDSTK CCCCCCCCCCCCCCC	28.34	23927012
618 (in isoform 2)	Phosphorylation	-	28.34	21406692
620	Phosphorylation	SSPEHSASSDSTKAP CCCCCCCCCCCCCCC	37.38	23927012
621	Phosphorylation	SPEHSASSDSTKAPQ CCCCCCCCCCCCCCC	34.98	23927012
623	Phosphorylation	EHSASSDSTKAPQTP CCCCCCCCCCCCCCC	33.48	23927012
624	Phosphorylation	HSASSDSTKAPQTPR CCCCCCCCCCCCCCC	35.89	23663014
629	Phosphorylation	DSTKAPQTPRSGAAH CCCCCCCCCCCCCCC	21.43	23927012
632	Phosphorylation	KAPQTPRSGAAHLCD CCCCCCCCCCCCCCC	33.71	25159151
640	Phosphorylation	GAAHLCDSQETNCST CCCCCCCCCCCCCCC	28.99	24732914
643	Phosphorylation	HLCDSQETNCSTAGH CCCCCCCCCCCCCCC	33.61	24732914
643 (in isoform 2)	Phosphorylation	-	33.61	27251275
646	Phosphorylation	DSQETNCSTAGHSKT CCCCCCCCCCCCCCC	24.30	24732914
647	Phosphorylation	SQETNCSTAGHSKTP CCCCCCCCCCCCCCC	38.57	24732914
651	Phosphorylation	NCSTAGHSKTPPSGA CCCCCCCCCCCCCCC	36.99	24732914
652	Acetylation	CSTAGHSKTPPSGAD CCCCCCCCCCCCCCC	60.42	26051181
653	Phosphorylation	STAGHSKTPPSGADS CCCCCCCCCCCCCCC	43.37	25159151
653 (in isoform 2)	Phosphorylation	-	43.37	-
656	Phosphorylation	GHSKTPPSGADSKTV CCCCCCCCCCCCCCE	48.06	24732914
660	Phosphorylation	TPPSGADSKTVKLKS CCCCCCCCCCEEECC	29.68	24732914
667	Phosphorylation	SKTVKLKSPVLSNTT CCCEEECCCCCCCCC	30.58	30266825
667 (in isoform 2)	Phosphorylation	-	30.58	24719451
671	Phosphorylation	KLKSPVLSNTTTEPA EECCCCCCCCCCCCC	32.15	30266825
671 (in isoform 2)	Phosphorylation	-	32.15	27251275
673	Phosphorylation	KSPVLSNTTTEPAST CCCCCCCCCCCCCCC	31.55	30266825
673 (in isoform 2)	Phosphorylation	-	31.55	-
674	Phosphorylation	SPVLSNTTTEPASTM CCCCCCCCCCCCCCC	33.15	30266825
674 (in isoform 2)	Phosphorylation	-	33.15	24719451
675	Phosphorylation	PVLSNTTTEPASTMS CCCCCCCCCCCCCCC	37.62	30266825
675 (in isoform 2)	Phosphorylation	-	37.62	-
679	Phosphorylation	NTTTEPASTMSPPPA CCCCCCCCCCCCCHH	35.04	29255136
679 (in isoform 2)	Phosphorylation	-	35.04	24719451
680	Phosphorylation	TTTEPASTMSPPPAK CCCCCCCCCCCCHHH	24.63	29255136
680 (in isoform 2)	Phosphorylation	-	24.63	27251275
682	Phosphorylation	TEPASTMSPPPAKKL CCCCCCCCCCHHHHH	34.05	29255136
682 (in isoform 2)	Phosphorylation	-	34.05	21406692
687	Acetylation	TMSPPPAKKLALSAK CCCCCHHHHHHHHHH	54.84	26051181
692	Phosphorylation	PAKKLALSAKKASTL HHHHHHHHHHHHHHH	32.22	20068231
692 (in isoform 2)	Phosphorylation	-	32.22	-
698	Phosphorylation	LSAKKASTLWRATGN HHHHHHHHHHHHHCC	34.89	23917254
703	Phosphorylation	ASTLWRATGNDLRPP HHHHHHHHCCCCCCC	28.13	19691289
713	Phosphorylation	DLRPPPPSPSSDLTH CCCCCCCCCCCCCCC	43.09	25159151
713 (in isoform 2)	Phosphorylation	-	43.09	27251275
715	Phosphorylation	RPPPPSPSSDLTHPM CCCCCCCCCCCCCCC	40.60	30266825
716	Phosphorylation	PPPPSPSSDLTHPMK CCCCCCCCCCCCCCC	39.77	30266825
719	Phosphorylation	PSPSSDLTHPMKTSH CCCCCCCCCCCCCCC	28.99	30266825
732	Phosphorylation	SHPVVASTWPVHRAR CCCEEEECCCCHHCE	24.85	28555341
742	Phosphorylation	VHRARAVSPAPQSSS CHHCEECCCCCCCCC	17.85	29255136
742 (in isoform 2)	Phosphorylation	-	17.85	24719451
747	Phosphorylation	AVSPAPQSSSRLQPP ECCCCCCCCCCCCCC	29.26	24732914
748	Phosphorylation	VSPAPQSSSRLQPPF CCCCCCCCCCCCCCC	17.77	24732914
749	Phosphorylation	SPAPQSSSRLQPPFS CCCCCCCCCCCCCCC	42.11	23403867
756	Phosphorylation	SRLQPPFSPHPTLLS CCCCCCCCCCCCCCC	28.24	26462736
756 (in isoform 2)	Phosphorylation	-	28.24	27251275
760	Phosphorylation	PPFSPHPTLLSSTPK CCCCCCCCCCCCCCC	36.98	21712546
763	Phosphorylation	SPHPTLLSSTPKPPG CCCCCCCCCCCCCCC	34.97	21712546
764	Phosphorylation	PHPTLLSSTPKPPGT CCCCCCCCCCCCCCC	49.01	26462736
765	Phosphorylation	HPTLLSSTPKPPGTS CCCCCCCCCCCCCCC	31.77	29214152
771	Phosphorylation	STPKPPGTSEPRSCS CCCCCCCCCCCCCCC	35.37	28555341
776	Phosphorylation	PGTSEPRSCSSISTA CCCCCCCCCCCHHHC	29.12	28122231
778	Phosphorylation	TSEPRSCSSISTALP CCCCCCCCCHHHCCC	31.77	28122231
779	Phosphorylation	SEPRSCSSISTALPQ CCCCCCCCHHHCCCC	25.53	28122231
781	Phosphorylation	PRSCSSISTALPQVN CCCCCCHHHCCCCCC	15.02	28122231
782	Phosphorylation	RSCSSISTALPQVNE CCCCCHHHCCCCCCH	30.46	28122231
793	Phosphorylation	QVNEDLVSLPHQLPE CCCHHHHCCCCCCCC	43.40	28450419
802	Phosphorylation	PHQLPEASEPPQSPS CCCCCCCCCCCCCCC	49.31	28450419
807	Phosphorylation	EASEPPQSPSEKRKK CCCCCCCCCCHHHCC	35.85	21082442
807 (in isoform 2)	Phosphorylation	-	35.85	27251275
809	Phosphorylation	SEPPQSPSEKRKKTF CCCCCCCCHHHCCCC	62.08	30576142
815	Phosphorylation	PSEKRKKTFVGEPQR CCHHHCCCCCCCHHH	26.96	26074081
825	Phosphorylation	GEPQRLGSETRLPQH CCHHHCCCCCCCCHH	40.15	25159151
825 (in isoform 2)	Phosphorylation	-	40.15	27251275
827	Phosphorylation	PQRLGSETRLPQHIR HHHCCCCCCCCHHHH	38.92	24732914
858	Phosphorylation	RPEDTAASALQEGQT CCCHHHHHHHHCCCC	27.35	28555341
865	Phosphorylation	SALQEGQTQRQPGSP HHHHCCCCCCCCCCC	36.25	27174698
871	Phosphorylation	QTQRQPGSPMYRREG CCCCCCCCCCCCCCC	17.12	30266825
871 (in isoform 2)	Phosphorylation	-	17.12	24719451
874	Phosphorylation	RQPGSPMYRREGQAQ CCCCCCCCCCCCCCC	15.20	23927012
874 (in isoform 2)	Phosphorylation	-	15.20	-
911	Phosphorylation	VTDGHHASSRKRRRK ECCCCCHHHHHHHHC	26.73	28555341
912	Phosphorylation	TDGHHASSRKRRRKG CCCCCHHHHHHHHCC	42.47	28555341
937	Phosphorylation	HQDPLRHSCSPMGDG CCCCCCCCCCCCCCC	15.17	23401153
939	Phosphorylation	DPLRHSCSPMGDGDP CCCCCCCCCCCCCCH	22.42	23927012
939 (in isoform 2)	Phosphorylation	-	22.42	21406692
952	Phosphorylation	DPEAMEESPRKKKKK CHHHHHHCHHHHHHH	19.39	23927012
952 (in isoform 2)	Phosphorylation	-	19.39	19664995
978	Phosphorylation	EDGHLKCPRSAKPQD HHCCCCCCCCCCCCC	26.28	28555341
980	Acetylation	GHLKCPRSAKPQDAV CCCCCCCCCCCCCCC	44.45	26051181
1021	Phosphorylation	PVSWNGERESDVVQE CCCCCCCCHHHHHHH	41.76	20860994
1023	Phosphorylation	SWNGERESDVVQELL CCCCCCHHHHHHHHH	7.15	-
1030	Phosphorylation	SDVVQELLKYSSDKA HHHHHHHHHHCCCCC	17.24	22985185
1031	Phosphorylation	DVVQELLKYSSDKAY HHHHHHHHHCCCCCC	30.39	22985185
1032	Phosphorylation	VVQELLKYSSDKAYG HHHHHHHHCCCCCCC	39.79	22985185
1042	Phosphorylation	DKAYGRKVLTWDGKM CCCCCCEEEEECCCC	25.21	29496963
1048	Phosphorylation	KVLTWDGKMSAVSQD EEEEECCCCCEECHH	29.07	29496963
1050	Phosphorylation	LTWDGKMSAVSQDAI EEECCCCCEECHHHH	4.07	19007248
1050 (in isoform 2)	Phosphorylation	-	4.07	-
1051	Phosphorylation	TWDGKMSAVSQDAIE EECCCCCEECHHHHH	23.27	21815630
1053	Phosphorylation	DGKMSAVSQDAIEDS CCCCCEECHHHHHHH	41.84	18077418
1053 (in isoform 2)	Phosphorylation	-	41.84	-
1058	Phosphorylation	AVSQDAIEDSRQART EECHHHHHHHHHHCC	17.32	28555341
1116	Phosphorylation	SVTHPAKAASLSYRR CCCCHHHHHHHCCCC	23.78	20068231
1118	Phosphorylation	THPAKAASLSYRR-- CCHHHHHHHCCCC--	17.69	20068231
1119	Phosphorylation	HPAKAASLSYRR--- CHHHHHHHCCCC---	18.72	20068231
1120	Phosphorylation	PAKAASLSYRR---- HHHHHHHCCCC----	34.16	20068231
1120 (in isoform 2)	Phosphorylation	-	34.16	-
1121	Phosphorylation	AKAASLSYRR----- HHHHHHCCCC-----	42.53	20068231
1121 (in isoform 2)	Phosphorylation	-	42.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBP36_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP36_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP36_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PARP1_HUMAN	PARP1	physical	19615732
CHD4_HUMAN	CHD4	physical	19615732
PPM1G_HUMAN	PPM1G	physical	19615732
PWP2_HUMAN	PWP2	physical	19615732
IFRD2_HUMAN	IFRD2	physical	19615732
STK25_HUMAN	STK25	physical	19615732
TBL3_HUMAN	TBL3	physical	19615732
WDR3_HUMAN	WDR3	physical	19615732
NOG2_HUMAN	GNL2	physical	19615732
UTP18_HUMAN	UTP18	physical	19615732
DDX41_HUMAN	DDX41	physical	19615732
TM104_HUMAN	TMEM104	physical	19615732
FANCI_HUMAN	FANCI	physical	19615732
PP6R3_HUMAN	PPP6R3	physical	19615732
DHX33_HUMAN	DHX33	physical	19615732
NUP85_HUMAN	NUP85	physical	19615732
MPND_HUMAN	MPND	physical	19615732
NUDC1_HUMAN	NUDCD1	physical	19615732
WDR36_HUMAN	WDR36	physical	19615732
SHPRH_HUMAN	SHPRH	physical	19615732
ANR52_HUMAN	ANKRD52	physical	19615732
LN28B_HUMAN	LIN28B	physical	19615732
NPM_HUMAN	NPM1	physical	19679658
SODM_HUMAN	SOD2	physical	21268071
TRI26_HUMAN	TRIM26	physical	23105109
MYC_HUMAN	MYC	physical	25775507
FBXW7_HUMAN	FBXW7	physical	25775507
DHX33_HUMAN	DHX33	physical	26186194
K0232_HUMAN	KIAA0232	physical	26186194
NPM_HUMAN	NPM1	physical	26186194
PJA1_HUMAN	PJA1	physical	26186194
CELR2_HUMAN	CELSR2	physical	26186194
DHR2_YEAST	DHR2	physical	26149687
NPM_HUMAN	NPM1	physical	28514442
DHX33_HUMAN	DHX33	physical	28514442
K0232_HUMAN	KIAA0232	physical	28514442
CELR2_HUMAN	CELSR2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP36_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-582; SER-667AND SER-682, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-513; SER-515;SER-613; SER-614; THR-653; SER-667; SER-682 AND SER-742, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-546; SER-582;SER-667 AND THR-680, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-464; SER-494; SER-667;SER-713; SER-742 AND SER-1048, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-874 AND SER-952, ANDMASS SPECTROMETRY.	17081983 [Abstract]