TM104_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM104_HUMAN
• UniProt AC: Q8NE00
• Protein Name: Transmembrane protein 104
• Gene Name: TMEM104
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAGEITETGELYSSYVGLVYMFNLIVGTGALTMPKAFATAGWLVSLVLLVFLGFMSFVTTTFVIEAMAAANAQLHWKRMENLKEEEDDDSSTASDSDVLIRDNYERAEKRPILSVQRRGSPNPFEITDRVEMGQMASMFFNKVGVNLFYFCIIVYLYGDLAIYAAAVPFSLMQVTCSATGNDSCGVEADTKYNDTDRCWGPLRRVDAYRIYLAIFTLLLGPFTFFDVQKTKYLQILTSLMRWIAFAVMIVLALIRIGHGQGEGHPPLADFSGVRNLFGVCVYSFMCQHSLPSLITPVSSKRHLTRLVFLDYVLILAFYGLLSFTAIFCFRGDSLMDMYTLNFARCDVVGLAAVRFFLGLFPVFTISTNFPIIAVTLRNNWKTLFHREGGTYPWVVDRVVFPTITLVPPVLVAFCTHDLESLVGITGAYAGTGIQYVIPAFLVYHCRRDTQLAFGCGVSNKHRSPFRHTFWVGFVLLWAFSCFIFVTANIILSETKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83 (in isoform 2)	Ubiquitination	-	74.74	21906983
83 (in isoform 1)	Ubiquitination	-	74.74	21890473
83	Ubiquitination	WKRMENLKEEEDDDS HHHHHCCCCCCCCCC	74.74	21906983
90	Phosphorylation	KEEEDDDSSTASDSD CCCCCCCCCCCCHHC	36.26	29255136
91	Phosphorylation	EEEDDDSSTASDSDV CCCCCCCCCCCHHCE	34.68	29255136
92	Phosphorylation	EEDDDSSTASDSDVL CCCCCCCCCCHHCEE	33.85	29255136
94	Phosphorylation	DDDSSTASDSDVLIR CCCCCCCCHHCEEEE	37.42	29255136
96	Phosphorylation	DSSTASDSDVLIRDN CCCCCCHHCEEEECC	27.42	29255136
104	Phosphorylation	DVLIRDNYERAEKRP CEEEECCHHHHHHCC	15.87	23090842
109 (in isoform 2)	Ubiquitination	-	63.59	21906983
109 (in isoform 1)	Ubiquitination	-	63.59	21890473
109	Ubiquitination	DNYERAEKRPILSVQ CCHHHHHHCCEEEEE	63.59	21906983
114	Phosphorylation	AEKRPILSVQRRGSP HHHCCEEEEECCCCC	19.54	29978859
120	Phosphorylation	LSVQRRGSPNPFEIT EEEECCCCCCCCCCC	21.49	29255136
127	Phosphorylation	SPNPFEITDRVEMGQ CCCCCCCCCCHHHHH	15.56	29978859
193	N-linked_Glycosylation	VEADTKYNDTDRCWG CCCCCCCCCCCCCCC	47.46	UniProtKB CARBOHYD
208	Phosphorylation	PLRRVDAYRIYLAIF CCCHHHHHHHHHHHH	7.96	22210691
211	Phosphorylation	RVDAYRIYLAIFTLL HHHHHHHHHHHHHHH	4.89	22210691
216	Phosphorylation	RIYLAIFTLLLGPFT HHHHHHHHHHHCCCC	15.47	22210691
232	Phosphorylation	FDVQKTKYLQILTSL CCCCHHHHHHHHHHH	14.74	29083192
237	Phosphorylation	TKYLQILTSLMRWIA HHHHHHHHHHHHHHH	22.80	29083192
238	Phosphorylation	KYLQILTSLMRWIAF HHHHHHHHHHHHHHH	19.40	29083192
381	Ubiquitination	VTLRNNWKTLFHREG EEECCCEEEEEECCC	37.16	21890473
381 (in isoform 1)	Ubiquitination	-	37.16	21890473
460	Ubiquitination	FGCGVSNKHRSPFRH EECCCCCCCCCCCCH	32.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM104_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM104_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM104_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM104_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-91; THR-92 AND SER-94,AND MASS SPECTROMETRY.
PubMed: 17081983